Synonym
Chlorpropylate; Acaralate; Rospin
IUPAC/Chemical Name
Benzeneacetic acid, 4-chloro-alpha-(4-chlorophenyl)-alpha-hydroxy-, 1-methylethyl ester
InChi Key
AXGUBXVWZBFQGA-UHFFFAOYSA-N
InChi Code
InChI=1S/C17H16Cl2O3/c1-11(2)22-16(20)17(21,12-3-7-14(18)8-4-12)13-5-9-15(19)10-6-13/h3-11,21H,1-2H3
SMILES Code
O=C(OC(C)C)C(O)(C1=CC=C(Cl)C=C1)C2=CC=C(Cl)C=C2
Purity
>98% (or refer to the Certificate of Analysis)
Shipping Condition
Shipped under ambient temperature as non-hazardous chemical. This product is stable enough for a few weeks during ordinary shipping and time spent in Customs.
Storage Condition
Dry, dark and at 0 - 4 C for short term (days to weeks) or -20 C for long term (months to years).
Solubility
Soluble in DMSO
Shelf Life
>2 years if stored properly
Drug Formulation
This drug may be formulated in DMSO
Stock Solution Storage
0 - 4 C for short term (days to weeks), or -20 C for long term (months).
HS Tariff Code
2934.99.9001
Preparing Stock Solutions
The following data is based on the
product
molecular weight
339.21
Batch specific molecular weights may vary
from batch to batch
due to the degree of hydration, which will
affect the solvent
volumes required to prepare stock solutions.
| Concentration / Solvent Volume / Mass |
1 mg |
5 mg |
10 mg |
| 1 mM |
1.15 mL |
5.76 mL |
11.51 mL |
| 5 mM |
0.23 mL |
1.15 mL |
2.3 mL |
| 10 mM |
0.12 mL |
0.58 mL |
1.15 mL |
| 50 mM |
0.02 mL |
0.12 mL |
0.23 mL |
1: Bartsch E, Eberle D, Ramsteiner K, Tomann A, Spindler M. The carbinole acaricides: chlorobenzilate and chloropropylate. Residue Rev. 1971;39:1-93. PubMed PMID: 5127234.
2: Bourke JB, Broderick EJ, Stoewsand GS. Elimination rate and tissue residues of chloropropylate and chlorobenzilate in rats. Bull Environ Contam Toxicol. 1970 Nov;5(6):509-14. doi: 10.1007/BF01539979. PubMed PMID: 23989414.
3: Knowles CO, Ahmad S. Comparative metabolism of chlorobenzilate, chloropropylate, and bromopropylate acaricides by rat hepatic enzymes. Can J Physiol Pharmacol. 1971 Jun;49(6):590-7. PubMed PMID: 5088463.
4: Pardini RS, Heidker JC, Baker TA, Payne B. Toxicology of various pesticides and their decomposition products on mitochondrial electron transport. Arch Environ Contam Toxicol. 1980;9(1):87-97. PubMed PMID: 6768341.
5: Fryzek JP, Garabrant DH, Harlow SD, Severson RK, Gillespie BW, Schenk M, Schottenfeld D. A case-control study of self-reported exposures to pesticides and pancreas cancer in southeastern Michigan. Int J Cancer. 1997 Jul 3;72(1):62-7. PubMed PMID: 9212224.
6: Kadir HA, Knowles CO. Inhibition of ATP dephosphorylation by acaricides with emphasis on the anti-ATPase activity of the carbodiimide metabolite of diafenthiuron. J Econ Entomol. 1991 Jun;84(3):801-5. PubMed PMID: 1832178.
7: ST John LE Jr, Lisk DJ. Metabolic studies with chloropropylate acaricide in the dairy cow. J Agric Food Chem. 1973 Jul-Aug;21(4):644-6. PubMed PMID: 4718937.
8: Miyazaki S, Boush GM, Matsumura F. Metabolism of 14C-chlorobenzilate and 14C-chloropropylate by Rhodotorula gracilis. Appl Microbiol. 1969 Dec;18(6):972-6. PubMed PMID: 5392608; PubMed Central PMCID: PMC378178.
9: Hofberg AH Jr, Heinrichs LC, Gentry GA. Collaborative study of a gas-liquid chromatographic method for the analysis of chlorobenzilate and chloropropylate. J Assoc Off Anal Chem. 1975 May;58(3):516-9. PubMed PMID: 1141178.
10: Bourke JB, Hackler LR, Stoewsand GS. The comparative metabolism of chloropropylate in plants and animals and the effect of dietary protein on its deposition, degradation, and elimination in animals. IMS Ind Med Surg. 1968 Jul;37(7):542. PubMed PMID: 5243513.
