Cgp 57813 | CAS#150608-41-6 | HIV-1 protease inhibitor

MedKoo Cat#: 524646 | Name: Cgp 57813

Description:

WARNING: This product is for research use only, not for human or veterinary use.

CGP 57813 is a lipophilic compound that acts as a inhibitor of human immunodeficiency virus type 1 (HIV-1) protease.

Chemical Structure

Cgp 57813

CAS#150608-41-6

Theoretical Analysis

MedKoo Cat#: 524646

Name: Cgp 57813

CAS#: 150608-41-6

Chemical Formula: C43H58N4O8

Exact Mass: 758.4255

Molecular Weight: 758.94

Elemental Analysis: C, 68.05; H, 7.70; N, 7.38; O, 16.86

Price and Availability

This product is currently not in stock but may be available through custom synthesis. To ensure cost efficiency, the minimum order quantity is 1 gram. The estimated lead time is 2 to 4 months, with pricing dependent on the complexity of the synthesis (typically high for intricate chemistries). Quotes for quantities below 1 gram will not be provided. To request a quote, please click the button below. Note: If this product becomes available in stock in the future, pricing will be listed accordingly.

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Related CAS #

No Data

Synonym

Cgp 57813; Cgp-57813; Cgp57813.

IUPAC/Chemical Name

Carbamic acid, (2-hydroxy-4-((4-methoxyphenyl)methyl)-5-((2-methyl-1-(((2-(4-morpholinyl)-2-oxo-1-(phenylmethyl)ethyl)amino)carbonyl)propyl)amino)-5-oxo-1-(phenylmethyl)pentyl)-, 1,1-dimethylethyl ester, (1S-(1R*,2R*,4S*,5(R*(R*))))-

InChi Key

DZUIFTBFVIXAMZ-YHKVADFHSA-N

InChi Code

InChI=1S/C43H58N4O8/c1-29(2)38(40(50)44-36(27-31-15-11-8-12-16-31)41(51)47-21-23-54-24-22-47)46-39(49)33(25-32-17-19-34(53-6)20-18-32)28-37(48)35(26-30-13-9-7-10-14-30)45-42(52)55-43(3,4)5/h7-20,29,33,35-38,48H,21-28H2,1-6H3,(H,44,50)(H,45,52)(H,46,49)/t33-,35+,36+,37+,38+/m1/s1

SMILES Code

C(N[C@H](C(N1CCOCC1)=O)Cc1ccccc1)([C@@H](NC([C@@H](C[C@@H]([C@@H](NC(OC(C)(C)C)=O)Cc1ccccc1)O)Cc1ccc(cc1)OC)=O)C(C)C)=O

Appearance

Solid powder

Purity

>98% (or refer to the Certificate of Analysis)

Shipping Condition

Shipped under ambient temperature as non-hazardous chemical. This product is stable enough for a few weeks during ordinary shipping and time spent in Customs.

Storage Condition

Dry, dark and at 0 - 4 C for short term (days to weeks) or -20 C for long term (months to years).

Solubility

Soluble in DMSO, not in water

Shelf Life

>2 years if stored properly

Drug Formulation

This drug may be formulated in DMSO

Stock Solution Storage

0 - 4 C for short term (days to weeks), or -20 C for long term (months).

HS Tariff Code

2934.99.9001

More Info

Instruction

View handling instruction

Preparing Stock Solutions

The following data is based on the product molecular weight 758.94 Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which will affect the solvent volumes required to prepare stock solutions.

Concentration / Solvent Volume / Mass	1 mg	5 mg	10 mg
1 mM	1.15 mL	5.76 mL	11.51 mL
5 mM	0.23 mL	1.15 mL	2.3 mL
10 mM	0.12 mL	0.58 mL	1.15 mL
50 mM	0.02 mL	0.12 mL	0.23 mL

1: Leroux JC, Cozens RM, Roesel JL, Galli B, Doelker E, Gurny R. pH-sensitive nanoparticles: an effective means to improve the oral delivery of HIV-1 protease inhibitors in dogs. Pharm Res. 1996 Mar;13(3):485-7. PubMed PMID: 8692747. 2: Leroux JC, Cozens R, Roesel JL, Galli B, Kubel F, Doelker E, Gurny R. Pharmacokinetics of a novel HIV-1 protease inhibitor incorporated into biodegradable or enteric nanoparticles following intravenous and oral administration to mice. J Pharm Sci. 1995 Dec;84(12):1387-91. PubMed PMID: 8748318.