Cgp 43487 | CAS#146388-56-9 | NMDA Receptor Antagonist

MedKoo Cat#: 524634 | Name: Cgp 43487

Description:

WARNING: This product is for research use only, not for human or veterinary use.

Cgp 43487 is a N-methyl-D-aspartate (NMDA) receptor antagonist. The competitive NMDA receptor antagonist, Cgp 43487, was able to elevate the convulsive threshold significantly.

Chemical Structure

Cgp 43487

CAS#146388-56-9

Theoretical Analysis

MedKoo Cat#: 524634

Name: Cgp 43487

CAS#: 146388-56-9

Chemical Formula: C8H16NO5P

Exact Mass: 237.0766

Molecular Weight: 237.19

Elemental Analysis: C, 40.51; H, 6.80; N, 5.91; O, 33.73; P, 13.06

Price and Availability

This product is currently not in stock but may be available through custom synthesis. To ensure cost efficiency, the minimum order quantity is 1 gram. The estimated lead time is 2 to 4 months, with pricing dependent on the complexity of the synthesis (typically high for intricate chemistries). Quotes for quantities below 1 gram will not be provided. To request a quote, please click the button below. Note: If this product becomes available in stock in the future, pricing will be listed accordingly.

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Related CAS #

No Data

Synonym

Cgp 43487; Cgp43487; Cgp-43487.

IUPAC/Chemical Name

(R,E)-(4-amino-5-ethoxy-2-methyl-5-oxopent-2-en-1-yl)phosphonic acid

InChi Key

OKDOWCKDTWNRCB-PTYLAXBQSA-N

InChi Code

InChI=1S/C8H16NO5P/c1-3-14-8(10)7(9)4-6(2)5-15(11,12)13/h4,7H,3,5,9H2,1-2H3,(H2,11,12,13)/b6-4+/t7-/m1/s1

SMILES Code

CCOC(=O)[C@@H](/C=C(\C)/CP(=O)(O)O)N

Appearance

Solid powder

Purity

>98% (or refer to the Certificate of Analysis)

Shipping Condition

Shipped under ambient temperature as non-hazardous chemical. This product is stable enough for a few weeks during ordinary shipping and time spent in Customs.

Storage Condition

Dry, dark and at 0 - 4 C for short term (days to weeks) or -20 C for long term (months to years).

Solubility

Soluble in DMSO, not in water

Shelf Life

>2 years if stored properly

Drug Formulation

This drug may be formulated in DMSO

Stock Solution Storage

0 - 4 C for short term (days to weeks), or -20 C for long term (months).

HS Tariff Code

2934.99.9001

More Info

Instruction

View handling instruction

Preparing Stock Solutions

The following data is based on the product molecular weight 237.19 Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which will affect the solvent volumes required to prepare stock solutions.

Concentration / Solvent Volume / Mass	1 mg	5 mg	10 mg
1 mM	1.15 mL	5.76 mL	11.51 mL
5 mM	0.23 mL	1.15 mL	2.3 mL
10 mM	0.12 mL	0.58 mL	1.15 mL
50 mM	0.02 mL	0.12 mL	0.23 mL

1: Gasior M, Borowicz K, Starownik R, Kleinrok Z, Czuczwar SJ. Ca2+ channel blockade and the antielectroshock activity of NMDA receptor antagonists, CGP 40116 and CGP 43487, in mice. Eur J Pharmacol. 1996 Sep 19;312(1):27-33. PubMed PMID: 8891575. 2: Dall'Olio R, Rimondini R, Gandolfi O. The competitive NMDA antagonists CGP 43487 and APV potentiate dopaminergic function. Psychopharmacology (Berl). 1995 Apr;118(3):310-5. PubMed PMID: 7617824.