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MedKoo Cat#: 555235 | Name: MK-8282

Description:

WARNING: This product is for research use only, not for human or veterinary use.

MK-8282 is a Potent G-Protein-Coupled Receptor 119 Agonist for the Treatment of Type 2 Diabetes. MK-8282, which shows improved glucose tolerance in multiple animal models and has excellent off-target profile.

Chemical Structure

MK-8282
MK-8282
CAS#Unknown

Theoretical Analysis

MedKoo Cat#: 555235

Name: MK-8282

CAS#: Unknown

Chemical Formula: C23H23ClFN5O5

Exact Mass: 503.1372

Molecular Weight: 503.92

Elemental Analysis: C, 54.82; H, 4.60; Cl, 7.03; F, 3.77; N, 13.90; O, 15.87

Price and Availability

This product is currently not in stock but may be available through custom synthesis. To ensure cost efficiency, the minimum order quantity is 1 gram. The estimated lead time is 2 to 4 months, with pricing dependent on the complexity of the synthesis (typically high for intricate chemistries). Quotes for quantities below 1 gram will not be provided. To request a quote, please click the button below. Note: If this product becomes available in stock in the future, pricing will be listed accordingly.
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Related CAS #
No Data
Synonym
MK-8282; MK 8282; MK8282;
IUPAC/Chemical Name
1-methylcyclopropyl (1R,5S,9r)-9-((6-((2-chloro-4-cyanophenyl)amino)-5-fluoropyrimidin-4-yl)oxy)-9-hydroxy-3-oxa-7-azabicyclo[3.3.1]nonane-7-carboxylate
InChi Key
VEICGGANAAJZBY-ANCIUUTRSA-N
InChi Code
InChI=1S/C23H23ClFN5O5/c1-22(4-5-22)35-21(31)30-8-14-10-33-11-15(9-30)23(14,32)34-20-18(25)19(27-12-28-20)29-17-3-2-13(7-26)6-16(17)24/h2-3,6,12,14-15,32H,4-5,8-11H2,1H3,(H,27,28,29)/t14-,15+,23+
SMILES Code
CC1(CC1)OC(N(C[C@@H]2COC3)C[C@@H]3[C@@]2(O)OC4=NC=NC(NC5=CC=C(C=C5Cl)C#N)=C4F)=O
Appearance
Solid powder
Purity
>98% (or refer to the Certificate of Analysis)
Shipping Condition
Shipped under ambient temperature as non-hazardous chemical. This product is stable enough for a few weeks during ordinary shipping and time spent in Customs.
Storage Condition
Dry, dark and at 0 - 4 C for short term (days to weeks) or -20 C for long term (months to years).
Solubility
Soluble in DMSO
Shelf Life
>2 years if stored properly
Drug Formulation
This drug may be formulated in DMSO
Stock Solution Storage
0 - 4 C for short term (days to weeks), or -20 C for long term (months).
HS Tariff Code
2934.99.9001
More Info

Preparing Stock Solutions

The following data is based on the product molecular weight 503.92 Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which will affect the solvent volumes required to prepare stock solutions.

Recalculate based on batch purity %
Concentration / Solvent Volume / Mass 1 mg 5 mg 10 mg
1 mM 1.15 mL 5.76 mL 11.51 mL
5 mM 0.23 mL 1.15 mL 2.3 mL
10 mM 0.12 mL 0.58 mL 1.15 mL
50 mM 0.02 mL 0.12 mL 0.23 mL
Discovery of MK-8282 as a Potent G-Protein-Coupled Receptor 119 Agonist for the Treatment of Type 2 Diabetes Santhosh F. Neelamkavil, Andrew W. Stamford, Timothy Kowalski, Dipshikha Biswas, Craig Boyle, Samuel Chackalamannil, Yan Xia, Charles Jayne, Bernard Neustadt, Jinsong Hao, Hong Liu, Xing Dai, Hana Baker, Brian Hawes, Kim O’Neill, Huadong Tang, and William J. Greenlee Publication Date (Web): April 10, 2018 (Letter) DOI: 10.1021/acsmedchemlett.8b00073