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MedKoo Cat#: 524434 | Name: BMS-433771 HCl hydrate

Description:

WARNING: This product is for research use only, not for human or veterinary use.

BMS 433771 is a potent inhibitor of RSV replication in vitro. It exhibits excellent potency against multiple laboratory and clinical isolates of both A and B RSV with an average EC of 20nM

Chemical Structure

BMS-433771 HCl hydrate
BMS-433771 HCl hydrate
CAS#380603-10-1

Theoretical Analysis

MedKoo Cat#: 524434

Name: BMS-433771 HCl hydrate

CAS#: 380603-10-1

Chemical Formula: C20H25Cl2N5O3

Exact Mass: 363.1695

Molecular Weight: 454.35

Elemental Analysis: C, 52.87; H, 5.55; Cl, 15.60; N, 15.41; O, 10.56

Price and Availability

This product is currently not in stock but may be available through custom synthesis. To ensure cost efficiency, the minimum order quantity is 1 gram. The estimated lead time is 2 to 4 months, with pricing dependent on the complexity of the synthesis (typically high for intricate chemistries). Quotes for quantities below 1 gram will not be provided. To request a quote, please click the button below. Note: If this product becomes available in stock in the future, pricing will be listed accordingly.
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Related CAS #
380603-12-3 (HCl) 543700-68-1 (free base) 543700-67-0 (HCl hydrate) 380603-10-1 (free base)
Synonym
BMS 433771; BMS433771; BMS-433771; BMS-433771 HCl hydrate; BMS-433771 HCl; BMS-433771 hydrochloride.
IUPAC/Chemical Name
2H-Imidazo(4,5-c)pyridin-2-one, 1-cyclopropyl-1,3-dihydro-3-((1-(3-hydroxypropyl)-1H-benzimidazol-2-yl)methyl)-, dihydrochloride, hydrate
InChi Key
QCSHJGIPXPVJKJ-UHFFFAOYSA-N
InChi Code
InChI=1S/C20H21N5O2.2ClH.H2O/c26-11-3-10-23-16-5-2-1-4-15(16)22-19(23)13-24-18-12-21-9-8-17(18)25(20(24)27)14-6-7-14;;;/h1-2,4-5,8-9,12,14,26H,3,6-7,10-11,13H2;2*1H;1H2
SMILES Code
O=C(N1C2CC2)N(CC3=NC4=CC=CC=C4N3CCCO)C5=C1C=CN=C5.[H]Cl.[H]Cl.[H]O[H]
Appearance
Solid powder
Purity
>98% (or refer to the Certificate of Analysis)
Shipping Condition
Shipped under ambient temperature as non-hazardous chemical. This product is stable enough for a few weeks during ordinary shipping and time spent in Customs.
Storage Condition
Dry, dark and at 0 - 4 C for short term (days to weeks) or -20 C for long term (months to years).
Solubility
Soluble in DMSO, not in water
Shelf Life
>2 years if stored properly
Drug Formulation
This drug may be formulated in DMSO
Stock Solution Storage
0 - 4 C for short term (days to weeks), or -20 C for long term (months).
HS Tariff Code
2934.99.9001
More Info

Preparing Stock Solutions

The following data is based on the product molecular weight 454.35 Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which will affect the solvent volumes required to prepare stock solutions.

Recalculate based on batch purity %
Concentration / Solvent Volume / Mass 1 mg 5 mg 10 mg
1 mM 1.15 mL 5.76 mL 11.51 mL
5 mM 0.23 mL 1.15 mL 2.3 mL
10 mM 0.12 mL 0.58 mL 1.15 mL
50 mM 0.02 mL 0.12 mL 0.23 mL
1: Haid S, Grethe C, Bankwitz D, Grunwald T, Pietschmann T. Identification of a Human Respiratory Syncytial Virus Cell Entry Inhibitor by Using a Novel Lentiviral Pseudotype System. J Virol. 2015 Dec 30;90(6):3065-73. doi: 10.1128/JVI.03074-15. PubMed PMID: 26719246; PubMed Central PMCID: PMC4810627. 2: Combrink KD, Gulgeze HB, Thuring JW, Yu KL, Civiello RL, Zhang Y, Pearce BC, Yin Z, Langley DR, Kadow KF, Cianci CW, Li Z, Clarke J, Genovesi EV, Medina I, Lamb L, Yang Z, Zadjura L, Krystal M, Meanwell NA. Respiratory syncytial virus fusion inhibitors. Part 6: an examination of the effect of structural variation of the benzimidazol-2-one heterocycle moiety. Bioorg Med Chem Lett. 2007 Sep 1;17(17):4784-90. Epub 2007 Jun 26. PubMed PMID: 17616396.