MedKoo Cat#: 585181 | Name: Sotetsuflavone

Description:

WARNING: This product is for research use only, not for human or veterinary use.

Sotetsuflavone is isolated from Cycas revoluta Thunb., and has anti-proliferative effects on tumor cells.

Chemical Structure

Sotetsuflavone
Sotetsuflavone
CAS#2608-21-1

Theoretical Analysis

MedKoo Cat#: 585181

Name: Sotetsuflavone

CAS#: 2608-21-1

Chemical Formula: C31H20O10

Exact Mass: 552.1056

Molecular Weight: 552.49

Elemental Analysis: C, 67.39; H, 3.65; O, 28.96

Price and Availability

This product is currently not in stock but may be available through custom synthesis. To ensure cost efficiency, the minimum order quantity is 1 gram. The estimated lead time is 2 to 4 months, with pricing dependent on the complexity of the synthesis (typically high for intricate chemistries). Quotes for quantities below 1 gram will not be provided. To request a quote, please click the button below. Note: If this product becomes available in stock in the future, pricing will be listed accordingly.
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Synonym
Sotetsuflavone
IUPAC/Chemical Name
8-(5-(5,7-dihydroxy-4-oxo-4H-chromen-2-yl)-2-hydroxyphenyl)-5-hydroxy-2-(4-hydroxyphenyl)-7-methoxy-4H-chromen-4-one
InChi Key
OIFVLHZEBAXHPM-UHFFFAOYSA-N
InChi Code
InChI=1S/C31H20O10/c1-39-26-13-23(38)30-22(37)12-24(14-2-5-16(32)6-3-14)41-31(30)28(26)18-8-15(4-7-19(18)34)25-11-21(36)29-20(35)9-17(33)10-27(29)40-25/h2-13,32-35,38H,1H3
SMILES Code
O=C1C=C(C2=CC=C(O)C=C2)OC3=C1C(O)=CC(OC)=C3C4=CC(C5=CC(C6=C(O5)C=C(O)C=C6O)=O)=CC=C4O
Appearance
Solid powder
Purity
>98% (or refer to the Certificate of Analysis)
Shipping Condition
Shipped under ambient temperature as non-hazardous chemical. This product is stable enough for a few weeks during ordinary shipping and time spent in Customs.
Storage Condition
Dry, dark and at 0 - 4 C for short term (days to weeks) or -20 C for long term (months to years).
Solubility
Soluble in DMSO
Shelf Life
>3 years if stored properly
Drug Formulation
This drug may be formulated in DMSO
Stock Solution Storage
0 - 4 C for short term (days to weeks), or -20 C for long term (months).
HS Tariff Code
2934.99.9001
More Info

Preparing Stock Solutions

The following data is based on the product molecular weight 552.49 Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which will affect the solvent volumes required to prepare stock solutions.

Recalculate based on batch purity %
Concentration / Solvent Volume / Mass 1 mg 5 mg 10 mg
1 mM 1.15 mL 5.76 mL 11.51 mL
5 mM 0.23 mL 1.15 mL 2.3 mL
10 mM 0.12 mL 0.58 mL 1.15 mL
50 mM 0.02 mL 0.12 mL 0.23 mL
1: Wang S, Yan Y, Cheng Z, Hu Y, Liu T. Sotetsuflavone suppresses invasion and metastasis in non-small-cell lung cancer A549 cells by reversing EMT via the TNF-α/NF-κB and PI3K/AKT signaling pathway. Cell Death Discov. 2018 Feb 14;4:26. doi: 10.1038/s41420-018-0026-9. eCollection 2018 Dec. PubMed PMID: 29531823; PubMed Central PMCID: PMC5841291. 2: Wang S, Hu Y, Yan Y, Cheng Z, Liu T. Sotetsuflavone inhibits proliferation and induces apoptosis of A549 cells through ROS-mediated mitochondrial-dependent pathway. BMC Complement Altern Med. 2018 Aug 9;18(1):235. doi: 10.1186/s12906-018-2300-z. PubMed PMID: 30092797; PubMed Central PMCID: PMC6085663. 3: Njock GBB, Grougnet R, Efstathiou A, Smirlis D, Genta-Jouve G, Michel S, Mbing JN, Kritsanida M. A Nitrile Glucoside and Biflavones from the Leaves of Campylospermum excavatum (Ochnaceae). Chem Biodivers. 2017 Nov;14(11). doi: 10.1002/cbdv.201700241. Epub 2017 Oct 21. PubMed PMID: 28695668. 4: Li SH, Zhang HJ, Niu XM, Yao P, Sun HD, Fong HH. Chemical constituents from Amentotaxus yunnanensis and Torreyayunnanensis. J Nat Prod. 2003 Jul;66(7):1002-5. PubMed PMID: 12880325. 5: Coulerie P, Nour M, Maciuk A, Eydoux C, Guillemot JC, Lebouvier N, Hnawia E, Leblanc K, Lewin G, Canard B, Figadère B. Structure-activity relationship study of biflavonoids on the Dengue virus polymerase DENV-NS5 RdRp. Planta Med. 2013 Sep;79(14):1313-8. doi: 10.1055/s-0033-1350672. Epub 2013 Aug 8. PubMed PMID: 23929244. 6: Cui XL, Li KJ, Ren HX, Zhang YJ, Liu XD, Bu BG, Wang L. Extract of Cycas revoluta Thunb. enhances the inhibitory effect of 5-fluorouracil on gastric cancer cells through the AKT-mTOR pathway. World J Gastroenterol. 2019 Apr 21;25(15):1854-1864. doi: 10.3748/wjg.v25.i15.1854. PubMed PMID: 31057299; PubMed Central PMCID: PMC6478614.