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MedKoo Cat#: 524407 | Name: Bentazepam
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Description:

WARNING: This product is for research use only, not for human or veterinary use.

Bentazepam is a thienodiazepine which is a benzodiazepine analog. It possesses anxiolytic, anticonvulsant, sedative and skeletal muscle relaxant properties. Peak plasma rates are achieved in around 2,5 hours after oral administration.

Chemical Structure

Bentazepam
Bentazepam
CAS#29462-18-8 (free base)

Theoretical Analysis

MedKoo Cat#: 524407

Name: Bentazepam

CAS#: 29462-18-8 (free base)

Chemical Formula: C17H16N2OS

Exact Mass: 296.0983

Molecular Weight: 296.39

Elemental Analysis: C, 68.89; H, 5.44; N, 9.45; O, 5.40; S, 10.82

Price and Availability

Size Price Availability Quantity
1mg USD 350.00 2 weeks
5mg USD 850.00 2 weeks
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Related CAS #
29462-19-9 (HCl) 29462-18-8 (free base) 52824-92-7 (sulfate)
Synonym
Bentazepam; Thiadipone; Tiadipone; Bentazepam [USAN:INN]; CI-718; Knoll brand of bentazepam; QM 6008; QM-6008; Thiadipone; Tiadipona;
IUPAC/Chemical Name
1,3,6,7,8,9-Hexahydro-5-phenyl-2H-(1)benzothieno(2,3-e)-1,4-diazepin-2-one
InChi Key
AIZFEOPQVZBNGH-UHFFFAOYSA-N
InChi Code
InChI=1S/C17H16N2OS/c20-14-10-18-16(11-6-2-1-3-7-11)15-12-8-4-5-9-13(12)21-17(15)19-14/h1-3,6-7H,4-5,8-10H2,(H,19,20)
SMILES Code
c1ccc(cc1)C2=NCC(=O)Nc3c2c4c(s3)CCCC4
Appearance
Solid powder
Purity
>98% (or refer to the Certificate of Analysis)
Shipping Condition
Shipped under ambient temperature as non-hazardous chemical. This product is stable enough for a few weeks during ordinary shipping and time spent in Customs.
Storage Condition
Dry, dark and at 0 - 4 C for short term (days to weeks) or -20 C for long term (months to years).
Solubility
Soluble in DMSO, not in water
Shelf Life
>2 years if stored properly
Drug Formulation
This drug may be formulated in DMSO
Stock Solution Storage
0 - 4 C for short term (days to weeks), or -20 C for long term (months).
HS Tariff Code
2934.99.9001
More Info
Solvent mg/mL mM
Solubility
DMF 15.0 50.61
DMSO 15.0 50.61
DMSO:PBS (pH 7.2) (1:3) 0.3 0.84
Note: There can be variations in solubility for the same chemical from different vendors or different batches from the same vendor. The following factors can affect the solubility of the same chemical: solvent used for crystallization, residual solvent content, polymorphism, salt versus free form, degree of hydration, solvent temperature. Please use the solubility data as a reference only. Warming and sonication will facilitate dissolving. Still have questions? Please contact our Technical Support scientists.

Preparing Stock Solutions

The following data is based on the product molecular weight 296.39 Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which will affect the solvent volumes required to prepare stock solutions.

Recalculate based on batch purity %
Concentration / Solvent Volume / Mass 1 mg 5 mg 10 mg
1 mM 1.15 mL 5.76 mL 11.51 mL
5 mM 0.23 mL 1.15 mL 2.3 mL
10 mM 0.12 mL 0.58 mL 1.15 mL
50 mM 0.02 mL 0.12 mL 0.23 mL
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Int J Clin Pharmacol Ther Toxicol. 1991 Nov;29(11):457-62. PMID: 1800395. 6: Andrade RJ, Lucena MI, Aguilar J, Lazo MD, Camargo R, Moreno P, García-Escaño MD, Marquez A, Alcántara R, Alcáin G. Chronic liver injury related to use of bentazepam: an unusual instance of benzodiazepine hepatotoxicity. Dig Dis Sci. 2000 Jul;45(7):1400-4. doi: 10.1023/a:1005520523502. PMID: 10961721. 7: Andrade RJ, López-Torres E, Lucena MI, Fernández Mdel C. Hepatitis aguda por bentazepam [Acute hepatitis due to bentazepam]. Med Clin (Barc). 2003 May 10;120(17):678-9. Spanish. PMID: 12747823. 8: Mariño EL, Fernandez Lastra C, Gonzalez Lopez F, Dominguez-Gil A, Garcia Santalla JL, Vorca G, Izquierdo JA, Ledesma-Jimeno A. Parametrization by non- linear regression and bayesian estimation of bentazepam in a multiple dosage regimen in humans. Int J Clin Pharmacol Ther Toxicol. 1987 Nov;25(11):627-32. PMID: 3429066. 9: Honorato J, Rubio A, Tristán C, Otero FJ, Garrido J. Estudio de farmacovigilancia con bentazepam en una muestra de 1.046 pacientes psiquiátricos ambulatorios [A pharmacovigilance study with bentazepam in a sample of 1046 psychiatric outpatients]. Rev Med Univ Navarra. 1990 Apr-Jun;34(2):80-8. Spanish. PMID: 1983365. 10: Fernández-Bañares F, Salas A, Esteve M, Espinós J, Forné M, Viver JM. Collagenous and lymphocytic colitis. evaluation of clinical and histological features, response to treatment, and long-term follow-up. Am J Gastroenterol. 2003 Feb;98(2):340-7. doi: 10.1111/j.1572-0241.2003.07225.x. PMID: 12591052. 11: Tomková J, Švidrnoch M, Maier V, Ondra P. Analysis of selected designer benzodiazepines by ultra high performance liquid chromatography with high- resolution time-of-flight mass spectrometry and the estimation of their partition coefficients by micellar electrokinetic chromatography. J Sep Sci. 2017 May;40(9):2037-2044. doi: 10.1002/jssc.201700069. Epub 2017 Apr 10. PMID: 28266783. 12: Huang W, Moody DE. Immunoassay detection of benzodiazepines and benzodiazepine metabolites in blood. J Anal Toxicol. 1995 Oct;19(6):333-42. doi: 10.1093/jat/19.6.333. PMID: 8926726. 13: Fernandez Lastra C, Gonzalez Lopez F, Dominguez-Gil A, Mariño EL. Discrimination of kinetic models in heteroscedastic parametric estimation of bentazepam following multiple dosing. Int J Clin Pharmacol Ther Toxicol. 1988 Jul;26(7):335-8. PMID: 3209281. 14: Mariño EL, Fernandez Lastra C, Gonzalez Lopez F, Martin Rey A, Dominguez-Gil A, Garcia-Santalla JL, Llorca G, Izquiexdo JA, Ledesma-Jimeno A. Simulation of plasma bentazepam levels in multiple dosage regimens from parameters established by non-linear regression and bayesian estimation. Int J Clin Pharmacol Ther Toxicol. 1987 Dec;25(12):664-9. PMID: 2893777. 15: Švidrnoch M, Boráňová B, Tomková J, Ondra P, Maier V. Simultaneous determination of designer benzodiazepines in human serum using non-aqueous capillary electrophoresis - Tandem mass spectrometry with successive multiple ionic - Polymer layer coated capillary. Talanta. 2018 Jan 1;176:69-76. doi: 10.1016/j.talanta.2017.08.010. Epub 2017 Aug 3. PMID: 28917807. 16: Andrade RJ, Lucena MI, Kaplowitz N, García-Muņoz B, Borraz Y, Pachkoria K, García-Cortés M, Fernández MC, Pelaez G, Rodrigo L, Durán JA, Costa J, Planas R, Barriocanal A, Guarner C, Romero-Gomez M, Muņoz-Yagüe T, Salmerón J, Hidalgo R. Outcome of acute idiosyncratic drug-induced liver injury: Long-term follow-up in a hepatotoxicity registry. Hepatology. 2006 Dec;44(6):1581-8. doi: 10.1002/hep.21424. PMID: 17133470. 17: Barnes Recker CK, Hoehns JD, Sutherland JE, Opheim EF. An online misadventure with haloperidol. Ann Pharmacother. 2003 Oct;37(10):1531. doi: 10.1345/aph.1D176. PMID: 14519026. 18: Gonzalez López F, Mariño EL, Dominguez-Gil A. Pharmacokinetics of tiadipone: a new anxiolytic. Int J Clin Pharmacol Ther Toxicol. 1986 Sep;24(9):482-4. PMID: 2877954. 19: Conde López V. Estudio clínico doble ciego cruzado con un nuevo psicofarmaco: la tiadipona (QM-6008), diacepam y placebo [Double-blind cross- over clinical study of a new psychopharmaceutic agent: thiadipone (QM-6008), diazepam and a placebo]. Actas Luso Esp Neurol Psiquiatr Cienc Afines. 1980 Nov- Dec;8(6):409-42. Spanish. PMID: 7008536. 20: Rivas López FA, López Soriano F, Mendoza Cerezo A, Jiménez Ferré J, Azurmendi Rodríguez JI, de la Rubia Nieto MA. Intoxicación benzodiacepínica mixta y reversión por flumacenil (Ro 15-1788) [Mixed benzodiazepine poisoning and reversal with flumazenil (Ro 15-1788)]. Rev Esp Anestesiol Reanim. 1989 Jan- Feb;36(1):48-50. Spanish. PMID: 2565591.