NCI-65828, also known as N 65828, is an angiogenin (ANG) inhibitor. It functions by inhibiting ANG's ribonucleolytic activity, which is essential for its biological functions. Studies have demonstrated that NCI-65828 effectively reduces ANG activity, leading to decreased cellular proliferation in various cancer cell lines, including UROtsa, T24, and HeLa, with IC₅₀ values of 3.2 ± 0.8 μM, 1.3 ± 0.5 μM, and 1.9 ± 0.4 μM, respectively. Additionally, NCI-65828 has been shown to inhibit endothelial tube formation, a key process in angiogenesis, in human umbilical vein endothelial cells (HUVECs). In vivo studies have indicated that NCI-65828 can prevent prostatic intraepithelial neoplasia (PIN) formation in mouse models by inhibiting ANG's enzymatic activity without affecting its nuclear translocation.
MedKoo Cat#: 565674
Name: NCI65828 sodium
CAS#: 6949-03-7 (sodium)
Chemical Formula: C22H16N3NaO4S
Exact Mass: 441.0759
Molecular Weight: 441.44
Elemental Analysis: C, 59.86; H, 3.65; N, 9.52; Na, 5.21; O, 14.50; S, 7.26
The following data is based on the product molecular weight 441.44 Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which will affect the solvent volumes required to prepare stock solutions.
| Concentration / Solvent Volume / Mass | 1 mg | 5 mg | 10 mg |
|---|---|---|---|
| 1 mM | 1.15 mL | 5.76 mL | 11.51 mL |
| 5 mM | 0.23 mL | 1.15 mL | 2.3 mL |
| 10 mM | 0.12 mL | 0.58 mL | 1.15 mL |
| 50 mM | 0.02 mL | 0.12 mL | 0.23 mL |
