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MedKoo Cat#: 524150 | Name: AG28262 free base

Description:

WARNING: This product is for research use only, not for human or veterinary use.

AG28262 is a VEFG-2 inhibitor. AG28262 causes an increase in serum ALT, due in part to both gene up-regulation.

Chemical Structure

AG28262 free base
AG28262 free base
CAS#638216-89-4 (free base)

Theoretical Analysis

MedKoo Cat#: 524150

Name: AG28262 free base

CAS#: 638216-89-4 (free base)

Chemical Formula: C22H18N4O2S2

Exact Mass: 434.0871

Molecular Weight: 434.53

Elemental Analysis: C, 60.81; H, 4.18; N, 12.89; O, 7.36; S, 14.76

Price and Availability

This product is currently not in stock but may be available through custom synthesis. To ensure cost efficiency, the minimum order quantity is 1 gram. The estimated lead time is 2 to 4 months, with pricing dependent on the complexity of the synthesis (typically high for intricate chemistries). Quotes for quantities below 1 gram will not be provided. To request a quote, please click the button below. Note: If this product becomes available in stock in the future, pricing will be listed accordingly.
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Related CAS #
638216-89-4 (free base) 881688-70-6 (besylate)
Synonym
AG-28262; AG 28262; AG28262; AG-28262 besylate
IUPAC/Chemical Name
Benzo(b)thiophene-3-carboxamide, N,2-dimethyl-6-((2-(1-methyl-1H-imidazol-2-yl)thieno(3,2-b)pyridin-7-yl)oxy)-
InChi Key
MNPIYFNULMJMIM-UHFFFAOYSA-N
InChi Code
InChI=1S/C22H18N4O2S2/c1-12-19(22(27)23-2)14-5-4-13(10-17(14)29-12)28-16-6-7-24-15-11-18(30-20(15)16)21-25-8-9-26(21)3/h4-11H,1-3H3,(H,23,27)
SMILES Code
O=C(C1=C(C)SC2=CC(OC3=C4C(C=C(C5=NC=CN5C)S4)=NC=C3)=CC=C21)NC
Appearance
Solid powder
Purity
>98% (or refer to the Certificate of Analysis)
Shipping Condition
Shipped under ambient temperature as non-hazardous chemical. This product is stable enough for a few weeks during ordinary shipping and time spent in Customs.
Storage Condition
Dry, dark and at 0 - 4 C for short term (days to weeks) or -20 C for long term (months to years).
Solubility
Soluble in DMSO, not in water
Shelf Life
>2 years if stored properly
Drug Formulation
This drug may be formulated in DMSO
Stock Solution Storage
0 - 4 C for short term (days to weeks), or -20 C for long term (months).
HS Tariff Code
2934.99.9001
More Info

Preparing Stock Solutions

The following data is based on the product molecular weight 434.53 Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which will affect the solvent volumes required to prepare stock solutions.

Recalculate based on batch purity %
Concentration / Solvent Volume / Mass 1 mg 5 mg 10 mg
1 mM 1.15 mL 5.76 mL 11.51 mL
5 mM 0.23 mL 1.15 mL 2.3 mL
10 mM 0.12 mL 0.58 mL 1.15 mL
50 mM 0.02 mL 0.12 mL 0.23 mL
1: Fuentealba C, Bera M, Jessen B, Sace F, Stevens GJ, Trajkovic D, Yang AH, Evering W. Evaluation of the effects of a VEGFR-2 inhibitor compound on alanine aminotransferase gene expression and enzymatic activity in the rat liver. Comp Hepatol. 2011 Aug 17;10:8. doi: 10.1186/1476-5926-10-8. PubMed PMID: 21846403; PubMed Central PMCID: PMC3173283. 2: Soda Y, Marumoto T, Friedmann-Morvinski D, Soda M, Liu F, Michiue H, Pastorino S, Yang M, Hoffman RM, Kesari S, Verma IM. Transdifferentiation of glioblastoma cells into vascular endothelial cells. Proc Natl Acad Sci U S A. 2011 Mar 15;108(11):4274-80. doi: 10.1073/pnas.1016030108. Epub 2011 Jan 24. PubMed PMID: 21262804; PubMed Central PMCID: PMC3060261.