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MedKoo Cat#: 591360 | Name: Agatoxin-489

Description:

WARNING: This product is for research use only, not for human or veterinary use.

Agatoxin-489 is a peptide toxin.

Chemical Structure

Agatoxin-489
Agatoxin-489
CAS#128549-96-2

Theoretical Analysis

MedKoo Cat#: 591360

Name: Agatoxin-489

CAS#: 128549-96-2

Chemical Formula: C26H47N7O2

Exact Mass: 489.3791

Molecular Weight: 489.71

Elemental Analysis: C, 63.77; H, 9.67; N, 20.02; O, 6.53

Price and Availability

This product is currently not in stock but may be available through custom synthesis. To ensure cost efficiency, the minimum order quantity is 1 gram. The estimated lead time is 2 to 4 months, with pricing dependent on the complexity of the synthesis (typically high for intricate chemistries). Quotes for quantities below 1 gram will not be provided. To request a quote, please click the button below. Note: If this product becomes available in stock in the future, pricing will be listed accordingly.
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Related CAS #
No Data
Synonym
Agatoxin-489; Agatoxin 489; Agatoxin489
IUPAC/Chemical Name
1H-Indole-3-acetamide, N-(20-amino-4-hydroxy-4,8,12,17-tetraazaeicos-1-yl)-
InChi Key
LIURIBSBVUMOJS-UHFFFAOYSA-N
InChi Code
InChI=1S/C26H47N7O2/c27-11-5-14-28-12-3-4-13-29-15-6-16-30-17-7-19-33(35)20-8-18-31-26(34)21-23-22-32-25-10-2-1-9-24(23)25/h1-2,9-10,22,28-30,32,35H,3-8,11-21,27H2,(H,31,34)
SMILES Code
O=C(NCCCN(O)CCCNCCCNCCCCNCCCN)CC1=CNC2=C1C=CC=C2
Appearance
Solid powder
Purity
>98% (or refer to the Certificate of Analysis)
Shipping Condition
Shipped under ambient temperature as non-hazardous chemical. This product is stable enough for a few weeks during ordinary shipping and time spent in Customs.
Storage Condition
Dry, dark and at 0 - 4 C for short term (days to weeks) or -20 C for long term (months to years).
Solubility
Soluble in DMSO
Shelf Life
>2 years if stored properly
Drug Formulation
This drug may be formulated in DMSO
Stock Solution Storage
0 - 4 C for short term (days to weeks), or -20 C for long term (months).
HS Tariff Code
2934.99.9001
More Info

Preparing Stock Solutions

The following data is based on the product molecular weight 489.71 Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which will affect the solvent volumes required to prepare stock solutions.

Recalculate based on batch purity %
Concentration / Solvent Volume / Mass 1 mg 5 mg 10 mg
1 mM 1.15 mL 5.76 mL 11.51 mL
5 mM 0.23 mL 1.15 mL 2.3 mL
10 mM 0.12 mL 0.58 mL 1.15 mL
50 mM 0.02 mL 0.12 mL 0.23 mL
1: Kim J, Alger BE. Reduction in endocannabinoid tone is a homeostatic mechanism for specific inhibitory synapses. Nat Neurosci. 2010 May;13(5):592-600. doi: 10.1038/nn.2517. Epub 2010 Mar 28. PubMed PMID: 20348918; PubMed Central PMCID: PMC2860695. 2: Kitaguchi T, Swartz KJ. An inhibitor of TRPV1 channels isolated from funnel Web spider venom. Biochemistry. 2005 Nov 29;44(47):15544-9. PubMed PMID: 16300403. 3: Kim YT, Park YJ, Jung SY, Seo WS, Suh CK. Effects of Na+-Ca2+ exchanger activity on the alpha-amino-3-hydroxy-5-methyl-4-isoxazolone-propionate-induced Ca2+ influx in cerebellar Purkinje neurons. Neuroscience. 2005;131(3):589-99. PubMed PMID: 15730865. 4: Albensi BC, Alasti N, Mueller AL. Long-term potentiation in the presence of NMDA receptor antagonist arylalkylamine spider toxins. J Neurosci Res. 2000 Oct 15;62(2):177-85. PubMed PMID: 11020211. 5: Kiskin NI, Chizhmakov IV, Tsyndrenko AYa, Mueller AL, Jackson H, Krishtal OA. A highly potent and selective N-methyl-D-aspartate receptor antagonist from the venom of the Agelenopsis aperta spider. Neuroscience. 1992 Nov;51(1):11-8. PubMed PMID: 1361215. 6: Herold EE, Yaksh TL. Anesthesia and muscle relaxation with intrathecal injections of AR636 and AG489, two acylpolyamine spider toxins, in rat. Anesthesiology. 1992 Sep;77(3):507-12. PubMed PMID: 1519789.