MedKoo Cat#: 318887 | Name: Tolmetin sodium dihydrate
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Description:

WARNING: This product is for research use only, not for human or veterinary use.

Tolmetin, also known as McN-2559, is a non-steroidal anti-inflammatory drug of the heterocyclic acetic acid derivative class. It is used primarily to reduce hormones that cause pain, swelling, tenderness, and stiffness in conditions such as osteoarthritis and rheumatoid arthritis, including juvenile rheumatoid arthritis.

Chemical Structure

Tolmetin sodium dihydrate
CAS#64490-92-2 (sodium hydrate)

Theoretical Analysis

MedKoo Cat#: 318887

Name: Tolmetin sodium dihydrate

CAS#: 64490-92-2 (sodium hydrate)

Chemical Formula: C15H18NNaO5

Exact Mass:

Molecular Weight: 315.30

Elemental Analysis: C, 57.14; H, 5.75; N, 4.44; Na, 7.29; O, 25.37

Price and Availability

Size Price Availability Quantity
1g USD 150.00
2g USD 250.00
5g USD 450.00
10g USD 750.00
25g USD 1,450.00
50g USD 2,150.00
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Related CAS #
64490-92-2 (sodium hydrate) 26171-23-3 (free acid) 35711-34-3 (sodium)
Synonym
Tolmetin, McN-2559, Tolectin sdoium; McN-2559-21-98; McN 2559 21 98; McN25592198, McN 2559, McN2559
IUPAC/Chemical Name
sodium 2-[1-methyl-5-(4-methylbenzoyl)pyrrol-2-yl]acetate dihydrate
InChi Key
QQILXENAYPUNEA-UHFFFAOYSA-M
InChi Code
InChI=1S/C15H15NO3.Na.2H2O/c1-10-3-5-11(6-4-10)15(19)13-8-7-12(16(13)2)9-14(17)18;;;/h3-8H,9H2,1-2H3,(H,17,18);;2*1H2/q;+1;;/p-1
SMILES Code
O=C([O-])CC1=CC=C(C(C2=CC=C(C)C=C2)=O)N1C.[H]O[H].[H]O[H].[Na+]
Appearance
White to light yellow crystalline powder.
Purity
>98% (or refer to the Certificate of Analysis)
Shipping Condition
Shipped under ambient temperature as non-hazardous chemical. This product is stable enough for a few weeks during ordinary shipping and time spent in Customs.
Storage Condition
Dry, dark and at 0 - 4 C for short term (days to weeks) or -20 C for long term (months to years).
Solubility
Soluble in DMSO, not in water
Shelf Life
>2 years if stored properly
Drug Formulation
This drug may be formulated in DMSO
Stock Solution Storage
0 - 4 C for short term (days to weeks), or -20 C for long term (months).
HS Tariff Code
2934.99.9001
More Info

Preparing Stock Solutions

The following data is based on the product molecular weight 315.30 Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which will affect the solvent volumes required to prepare stock solutions.

Recalculate based on batch purity %
Concentration / Solvent Volume / Mass 1 mg 5 mg 10 mg
1 mM 1.15 mL 5.76 mL 11.51 mL
5 mM 0.23 mL 1.15 mL 2.3 mL
10 mM 0.12 mL 0.58 mL 1.15 mL
50 mM 0.02 mL 0.12 mL 0.23 mL
1: Larsen JR, Becher JW. Fatal fulminant autoimmune haemolytic anaemia associated with tolmetin use and gastric carcinoma. Case report and literature review. Drug Saf. 1993 Feb;8(2):169-78. Review. PubMed PMID: 8452658. 2: Grindel JM. The pharmacokinetic and metabolic profile of the antiinflammatory agent tolmetin in laboratory animals and man. Drug Metab Rev. 1981;12(2):363-77. Review. PubMed PMID: 7040019. 3: Brogden RN, Heel RC, Speight TM, Avery GS. Tolmetin: a review of its pharmacological properties and therapeutic efficacy in rheumatic diseases. Drugs. 1978 Jun;15(6):429-50. Review. PubMed PMID: 350558. 4: Calin A. Clinical use of tolmetin sodium in patients with ankylosing spondylitis: a review. J Clin Pharmacol. 1983 Jul;23(7):301-8. Review. PubMed PMID: 6350376.