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MedKoo Cat#: 318582 | Name: Promethazine HCl
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Description:

WARNING: This product is for research use only, not for human or veterinary use.

Promethazine Hydrochloride is an antiemetic, antihistaminic, and CNS depressant. Promethazine Hydrochloride is a first generation histamine H1 receptor antagonist whose antihistamine activity. Promethazine can penetrate the CNS, depressing central H1-receptor activity, which may relate to its sedative properties, and can also inhibit muscarinic acetylcholine receptors.

Chemical Structure

Promethazine HCl
Promethazine HCl
CAS#58-33-3 (HCl)

Theoretical Analysis

MedKoo Cat#: 318582

Name: Promethazine HCl

CAS#: 58-33-3 (HCl)

Chemical Formula: C17H21ClN2S

Exact Mass: 0.0000

Molecular Weight: 320.88

Elemental Analysis: C, 63.63; H, 6.60; Cl, 11.05; N, 8.73; S, 9.99

Price and Availability

Size Price Availability Quantity
10g USD 450.00 2 Weeks
50g USD 750.00 2 Weeks
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Related CAS #
60-87-7 (free base) 58-33-3 (HCl) 96590-75-9 (hibenzate)
Synonym
Promethazine Hydrochloride; Phenergan; Promethazine Hcl; Fenergan; N,N-dimethyl-1-(10H-phenothiazin-10-yl)propan-2-amine hydrochloride; Prothazin; Pyrethia; Remsed; Rumergan; Promet; Prometazin; sopromethazine; Phenargan; Phenergan; Phensedyl; Pipolfen; Pipolphen;
IUPAC/Chemical Name
N,N-dimethyl-1-phenothiazin-10-ylpropan-2-amine;hydrochloride
InChi Key
XXPDBLUZJRXNNZ-UHFFFAOYSA-N
InChi Code
InChI=1S/C17H20N2S.ClH/c1-13(18(2)3)12-19-14-8-4-6-10-16(14)20-17-11-7-5-9-15(17)19;/h4-11,13H,12H2,1-3H3;1H
SMILES Code
CC(CN1C2=CC=CC=C2SC3=CC=CC=C31)N(C)C.Cl
Appearance
Solid powder
Purity
>98% (or refer to the Certificate of Analysis)
Shipping Condition
Shipped under ambient temperature as non-hazardous chemical. This product is stable enough for a few weeks during ordinary shipping and time spent in Customs.
Storage Condition
Dry, dark and at 0 - 4 C for short term (days to weeks) or -20 C for long term (months to years).
Solubility
Soluble in DMSO, not in water
Shelf Life
>2 years if stored properly
Drug Formulation
This drug may be formulated in DMSO
Stock Solution Storage
0 - 4 C for short term (days to weeks), or -20 C for long term (months).
HS Tariff Code
2934.99.9001
More Info

Preparing Stock Solutions

The following data is based on the product molecular weight 320.88 Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which will affect the solvent volumes required to prepare stock solutions.

Recalculate based on batch purity %
Concentration / Solvent Volume / Mass 1 mg 5 mg 10 mg
1 mM 1.15 mL 5.76 mL 11.51 mL
5 mM 0.23 mL 1.15 mL 2.3 mL
10 mM 0.12 mL 0.58 mL 1.15 mL
50 mM 0.02 mL 0.12 mL 0.23 mL
1: Lalfamkima F, Debnath SC, Adhyapok AK. A study of promethazine hydrochloride and pentazocine intramuscular sedation along with 2 % lidocaine hydrochloride and adrenaline and comparison to placebo along with 2 % lidocaine hydrochloride and adrenaline for surgical extraction of mandibular third molar. J Maxillofac Oral Surg. 2015 Mar;14(1):90-100. doi: 10.1007/s12663-013-0595-3. Epub 2013 Nov 30. PubMed PMID: 25729232; PubMed Central PMCID: PMC4339336. 2: Peacock GF, Sauvageot J. Evaluation of the stability of promethazine hydrochloride in pluronic lecithin organogel and the determination of an appropriate beyond-use date. Int J Pharm Compd. 2014 Jul-Aug;18(4):345-7. PubMed PMID: 25508643. 3: Peacock GF, Sauvageot J. Evaluation of the stability of promethazine hydrochloride in pluronic lecithin organogel and the determination of an appropriate beyond-use date. Int J Pharm Compd. 2014 Jul-Aug;18(4):345-7. PubMed PMID: 25474864. 4: G Dehghan MH, Marzuka M. Lyophilized Chitosan/xanthan Polyelectrolyte Complex Based Mucoadhesive Inserts for Nasal Delivery of Promethazine Hydrochloride. Iran J Pharm Res. 2014 Summer;13(3):769-84. PubMed PMID: 25276178; PubMed Central PMCID: PMC4177638. 5: Wyszomirska E, Czerwińska K, Kublin E, Mazurek AP. Identification and determination of ketotifen hydrogen fumarate, azelastine hydrochloride, dimetindene maleate and promethazine hydrochloride by densitometric method. Acta Pol Pharm. 2013 Nov-Dec;70(6):951-9. PubMed PMID: 24383318. 6: Mahajan RK, Mahajan S, Bhadani A, Singh S. Physicochemical studies of pyridinium gemini surfactants with promethazine hydrochloride in aqueous solution. Phys Chem Chem Phys. 2012 Jan 14;14(2):887-98. doi: 10.1039/c1cp22448d. Epub 2011 Nov 25. PubMed PMID: 22119804. 7: He LL, Wang X, Liu B, Wang J, Sun YG, Xu SK. Study on the sonodynamic activity and mechanism of promethazine hydrochloride by multi-spectroscopic techniques. Spectrochim Acta A Mol Biomol Spectrosc. 2011 Oct 15;81(1):698-705. doi: 10.1016/j.saa.2011.07.006. Epub 2011 Jul 8. PubMed PMID: 21788155. 8: Naqvi AZ, Khatoon S, Kabir-ud-Din. Cloud point variation of amphiphilic drug promethazine hydrochloride with added surfactants. Colloids Surf B Biointerfaces. 2011 Dec 1;88(2):568-73. doi: 10.1016/j.colsurfb.2011.07.034. Epub 2011 Jul 23. PubMed PMID: 21871787. 9: Asghar MN, Khan IU, Bano N. In vitro antioxidant and radical-scavenging capacities of Citrullus colocynthes (L) and Artemisia absinthium extracts using promethazine hydrochloride radical cation and contemporary assays. Food Sci Technol Int. 2011 Oct;17(5):481-94. doi: 10.1177/1082013211399495. Epub 2011 Sep 27. PubMed PMID: 21954313. 10: Xi X, Ming L, Liu J. Voltammetric determination of promethazine hydrochloride at a multi-wall carbon nanotube modified glassy carbon electrode. Drug Test Anal. 2011 Mar;3(3):182-6. doi: 10.1002/dta.205. Epub 2010 Dec 1. PubMed PMID: 21125640. 11: Kabir-Ud-Din, Rub MA, Naqvi AZ. Mixed micelles of amphiphilic drug promethazine hydrochloride and surfactants (conventional and gemini) at 293.15K to 308.15K: Composition, interaction and stability of the aggregates. J Colloid Interface Sci. 2011 Feb 15;354(2):700-8. doi: 10.1016/j.jcis.2010.11.005. Epub 2010 Nov 11. PubMed PMID: 21134682. 12: Hassan AK, Saad B, Ghani SA, Adnan R, Rahim AA, Ahmad N, Mokhtar M, Ameen ST, Al-Araji SM. Ionophore-based potentiometric sensors for the flow-injection determination of promethazine hydrochloride in pharmaceutical formulations and human urine. Sensors (Basel). 2011;11(1):1028-42. doi: 10.3390/s110101028. Epub 2011 Jan 18. PubMed PMID: 22346617; PubMed Central PMCID: PMC3274102. 13: Chen P, Hu X, Liu S, Liu Z, Song Y. Study on the resonance nonlinear scattering spectra of the interactions of promethazine hydrochloride and chlorpromazine hydrochloride with 12-tungstophosphoric acid and their analytical applications. Spectrochim Acta A Mol Biomol Spectrosc. 2010 Sep 15;77(1):207-12. doi: 10.1016/j.saa.2010.05.009. Epub 2010 May 24. PubMed PMID: 20541454. 14: Clatts M, Giang le M, Goldsamt L, Colón-López V. Nonmedical use of promethazine hydrochloride among heroin injectors in Vietnam: unrecognized risks and unintended consequences. Subst Use Misuse. 2010 Mar;45(4):515-27. doi: 10.3109/10826080903452520. PubMed PMID: 20141462. 15: Liu P, Liang S, Wang BJ, Guo RC. Pharmacokinetics, safety and tolerance of single- and multiple-dose of a novel compound tramadol hydrochloride injection (35 mg tramadol hydrochloride, 45 mgl promethazine hydrochloride) in Chinese healthy subjects. Eur J Drug Metab Pharmacokinet. 2009 Jul-Sep;34(3-4):193-200. PubMed PMID: 20166438. 16: Liu P, Liang S, Wang BJ, Guo RC. Development and validation of a sensitive LC-MS method for the determination of promethazine hydrochloride in human plasma and urine. Eur J Drug Metab Pharmacokinet. 2009 Jul-Sep;34(3-4):177-84. PubMed PMID: 20166436. 17: Thumma S, Repka MA. Compatibility studies of promethazine hydrochloride with tablet excipients by means of thermal and non-thermal methods. Pharmazie. 2009 Mar;64(3):183-9. PubMed PMID: 19348341. 18: Alam MS, Naqvi AZ, Kabir-ud-Din. Influence of electrolytes/non-electrolytes on the cloud point phenomenon of the aqueous promethazine hydrochloride drug solution. J Colloid Interface Sci. 2007 Feb 1;306(1):161-5. Epub 2006 Oct 14. PubMed PMID: 17069828. 19: Gereli G, Seki Y, Murat Kuşoğlu I, Yurdakoç K. Equilibrium and kinetics for the sorption of promethazine hydrochloride onto K10 montmorillonite. J Colloid Interface Sci. 2006 Jul 1;299(1):155-62. Epub 2006 Mar 9. PubMed PMID: 16527295. 20: Kubacák P, Mikus P, Valásková I, Havránek E. Determination of promethazine hydrochloride in pharmaceuticals by capillary isotachophoresis. Methods Find Exp Clin Pharmacol. 2005 Oct;27(8):529-32. PubMed PMID: 16273131.

View History

CP-195543

CP-195543