MedKoo Biosciences, Inc.
Tel:   +1-919-636-5577    Fax:   +1-919-980-4831    Email:   sales@medkoo.com
Search
Login Register
Search
MedKoo Cat#: 581070 | Name: Promethazine hibenzate

Description:

WARNING: This product is for research use only, not for human or veterinary use.

Promethazine is a neuroleptic medication and first-generation antihistamine of the phenothiazine family. The drug has strong sedative and weak antipsychotic effects.

Chemical Structure

Promethazine hibenzate
Promethazine hibenzate
CAS#96590-75-9 (hibenzate)

Theoretical Analysis

MedKoo Cat#: 581070

Name: Promethazine hibenzate

CAS#: 96590-75-9 (hibenzate)

Chemical Formula: C31H30N2O4S

Exact Mass:

Molecular Weight: 526.65

Elemental Analysis: C, 70.70; H, 5.74; N, 5.32; O, 12.15; S, 6.09

Price and Availability

This product is currently not in stock but may be available through custom synthesis. To ensure cost efficiency, the minimum order quantity is 1 gram. The estimated lead time is 2 to 4 months, with pricing dependent on the complexity of the synthesis (typically high for intricate chemistries). Quotes for quantities below 1 gram will not be provided. To request a quote, please click the button below. Note: If this product becomes available in stock in the future, pricing will be listed accordingly.
Bulk Inquiry
Related CAS #
60-87-7 (free base) 58-33-3 (HCl) 96590-75-9 (hibenzate)
Synonym
Promethazine hibenzate; D08768; D-08768; D 08768.
IUPAC/Chemical Name
2-(4-Hydroxybenzoyl)benzoic acid - N,N-dimethyl-1-(10H-phenothiazin-10-yl)-2-propanamine (1:1)
InChi Key
WCYMACWVZQIWLM-UHFFFAOYSA-N
InChi Code
InChI=1S/C17H20N2S.C14H10O4/c1-13(18(2)3)12-19-14-8-4-6-10-16(14)20-17-11-7-5-9-15(17)19;15-10-7-5-9(6-8-10)13(16)11-3-1-2-4-12(11)14(17)18/h4-11,13H,12H2,1-3H3;1-8,15H,(H,17,18)
SMILES Code
O=C(O)C1=CC=CC=C1C(C2=CC=C(O)C=C2)=O.CC(N(C)C)CN3C4=C(C=CC=C4)SC5=CC=CC=C35
Appearance
Solid powder
Purity
>98% (or refer to the Certificate of Analysis)
Shipping Condition
Shipped under ambient temperature as non-hazardous chemical. This product is stable enough for a few weeks during ordinary shipping and time spent in Customs.
Storage Condition
Dry, dark and at 0 - 4 C for short term (days to weeks) or -20 C for long term (months to years).
Solubility
Soluble in DMSO
Shelf Life
>2 years if stored properly
Drug Formulation
This drug may be formulated in DMSO
Stock Solution Storage
0 - 4 C for short term (days to weeks), or -20 C for long term (months).
HS Tariff Code
2934.99.9001
More Info

Preparing Stock Solutions

The following data is based on the product molecular weight 526.65 Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which will affect the solvent volumes required to prepare stock solutions.

Recalculate based on batch purity %
Concentration / Solvent Volume / Mass 1 mg 5 mg 10 mg
1 mM 1.15 mL 5.76 mL 11.51 mL
5 mM 0.23 mL 1.15 mL 2.3 mL
10 mM 0.12 mL 0.58 mL 1.15 mL
50 mM 0.02 mL 0.12 mL 0.23 mL
1: Brilhante RSN, de Oliveira JS, de Jesus Evangelista AJ, Pereira VS, Alencar LP, Castelo-Branco DSCM, Câmara LMC, de Lima-Neto RG, Cordeiro RA, Sidrim JJC, Rocha MFG. In vitro effects of promethazine on cell morphology and structure and mitochondrial activity of azole-resistant Candida tropicalis. Med Mycol. 2017 Oct 9. doi: 10.1093/mmy/myx088. [Epub ahead of print] PubMed PMID: 29420801. 2: Nadri S, Mahmoudvand H, Taee N, Anbari K, Beiranvand S. Promethazine and Oral Midazolam Preanesthetic Children Medication. Pediatr Emerg Care. 2018 Jan 15. doi: 10.1097/PEC.0000000000001389. [Epub ahead of print] PubMed PMID: 29337835. 3: Talebpour M, Ghiasnejad Omrani N, Imani F, Shariat Moharari R, Pourfakhr P, Khajavi MR. Comparison Effect of Promethazine/Dexamethasone and Metoclopramide /Dexamethasone on Postoperative Nausea and Vomiting after Laparascopic Gastric Placation: A Randomized Clinical Trial. Anesth Pain Med. 2017 Jul 22;7(4):e57810. doi: 10.5812/aapm.57810. eCollection 2017 Aug. PubMed PMID: 29226110; PubMed Central PMCID: PMC5712203. 4: Motamed H, Moezzi M, Rooyfard AD, Angali KA, Izadi Z. A Comparison of the Effects and Side Effects of Oral Betahistine with Injectable Promethazine in the Treatment of Acute Peripheral Vertigo in Emergency. J Clin Med Res. 2017 Dec;9(12):994-997. doi: 10.14740/jocmr3093w. Epub 2017 Nov 6. PubMed PMID: 29163732; PubMed Central PMCID: PMC5687903. 5: Kasai T, Nakatani M, Ishiguro N, Ohno K, Yamamoto N, Morita M, Yamada H, Tsuchida K, Uezumi A. Promethazine Hydrochloride Inhibits Ectopic Fat Cell Formation in Skeletal Muscle. Am J Pathol. 2017 Dec;187(12):2627-2634. doi: 10.1016/j.ajpath.2017.08.008. Epub 2017 Sep 15. PubMed PMID: 28919111. 6: Nusrat S, Zaman M, Masroor A, Siddqi MK, Zaidi N, Neelofar K, Abdelhameed AS, Khan RH. Deciphering the enhanced inhibitory, disaggregating and cytoprotective potential of promethazine towards amyloid fibrillation. Int J Biol Macromol. 2018 Jan;106:851-863. doi: 10.1016/j.ijbiomac.2017.08.081. Epub 2017 Aug 16. PubMed PMID: 28823512. 7: Geng X, Li F, Yip J, Peng C, Elmadhoun O, Shen J, Ji X, Ding Y. Erratum to: Neuroprotection by Chlorpromazine and Promethazine in Severe Transient and Permanent Ischemic Stroke. Mol Neurobiol. 2017 Dec;54(10):8151. doi: 10.1007/s12035-017-0656-6. PubMed PMID: 28660483. 8: Facchini G, Eberlin S, Clerici SP, Alves Pinheiro ALT, Costa A. Ultraviolet A photosensitivity profile of dexchlorpheniramine maleate and promethazine-based creams: Anti-inflammatory, antihistaminic, and skin barrier protection properties. J Cosmet Dermatol. 2017 Dec;16(4):e59-e67. doi: 10.1111/jocd.12349. Epub 2017 Jun 7. PubMed PMID: 28593645. 9: Diaz-Artiles A, Priesol AJ, Clark TK, Sherwood DP, Oman CM, Young LR, Karmali F. The Impact of Oral Promethazine on Human Whole-Body Motion Perceptual Thresholds. J Assoc Res Otolaryngol. 2017 Aug;18(4):581-590. doi: 10.1007/s10162-017-0622-z. Epub 2017 Apr 24. PubMed PMID: 28439720; PubMed Central PMCID: PMC5532182. 10: Cunha RR, Ribeiro MMAC, Muñoz RAA, Richter EM. Fast determination of codeine, orphenadrine, promethazine, scopolamine, tramadol, and paracetamol in pharmaceutical formulations by capillary electrophoresis. J Sep Sci. 2017 Apr;40(8):1815-1823. doi: 10.1002/jssc.201601275. Epub 2017 Mar 21. PubMed PMID: 28217928. 11: Sidrim JJ, Vasconcelos DC, Riello GB, Guedes GM, Serpa R, Bandeira TJ, Monteiro AJ, Cordeiro RA, Castelo-Branco DS, Rocha MF, Brilhante RS. Promethazine improves antibiotic efficacy and disrupts biofilms of Burkholderia pseudomallei. Biofouling. 2017 Jan;33(1):88-97. doi: 10.1080/08927014.2016.1262846. Epub 2016 Dec 12. PubMed PMID: 27936915. 12: Geng X, Li F, Yip J, Peng C, Elmadhoun O, Shen J, Ji X, Ding Y. Neuroprotection by Chlorpromazine and Promethazine in Severe Transient and Permanent Ischemic Stroke. Mol Neurobiol. 2017 Dec;54(10):8140-8150. doi: 10.1007/s12035-016-0280-x. Epub 2016 Nov 28. Erratum in: Mol Neurobiol. 2017 Jun 28;:. PubMed PMID: 27896650. 13: Huf G, Alexander J, Gandhi P, Allen MH. Haloperidol plus promethazine for psychosis-induced aggression. Cochrane Database Syst Rev. 2016 Nov 25;11:CD005146. Review. PubMed PMID: 27885664. 14: Aleyasin A, Saffarieh E, Torkamandi H, Hanafi S, Sadeghi F, Mahdavi A, Bahmaei F, Javadi M. Comparison of Efficacy of Granisetron and Promethazine in Control of Hyperemesis Gravidarum. J Obstet Gynaecol India. 2016 Dec;66(6):409-414. Epub 2015 Oct 7. PubMed PMID: 27821979; PubMed Central PMCID: PMC5080214. 15: Bergese SD, Puente EG, Antor MA, Viloria AL, Yildiz V, Kumar NA, Uribe AA. A Prospective, Randomized, Double-Blinded, Double-Dummy Pilot Study to Assess the Preemptive Effect of Triple Therapy with Aprepitant, Dexamethasone, and Promethazine versus Ondansetron, Dexamethasone and Promethazine on Reducing the Incidence of Postoperative Nausea and Vomiting Experienced by Patients Undergoing Craniotomy Under General Anesthesia. Front Med (Lausanne). 2016 Jul 5;3:29. doi: 10.3389/fmed.2016.00029. eCollection 2016. PubMed PMID: 27458584; PubMed Central PMCID: PMC4932110. 16: He LL, Wang ZX, Wang YX, Liu XP, Yang YJ, Gao YP, Wang X, Liu B, Wang X. Studies on the interaction between promethazine and human serum albumin in the presence of flavonoids by spectroscopic and molecular modeling techniques. Colloids Surf B Biointerfaces. 2016 Sep 1;145:820-829. doi: 10.1016/j.colsurfb.2016.06.001. Epub 2016 Jun 2. PubMed PMID: 27315330. 17: Hotta E, Nakai N, Katoh N. Multiple Fixed Drug Eruption Caused by Promethazine Methylene Disalicylate as One of the Components of PL(®) Combination Granules. Indian J Dermatol. 2016 May-Jun;61(3):348. doi: 10.4103/0019-5154.182468. PubMed PMID: 27293277; PubMed Central PMCID: PMC4885210. 18: Guimaraes DD, Andrews PL, Rudd JA, Braga VA, Nalivaiko E. Ondansetron and promethazine have differential effects on hypothermic responses to lithium chloride administration and to provocative motion in rats. Temperature (Austin). 2015 Oct 27;2(4):543-53. doi: 10.1080/23328940.2015.1071700. eCollection 2015 Oct-Dec. PubMed PMID: 27227074; PubMed Central PMCID: PMC4843929. 19: Bergese SD, Puente EG, Antor MA, Capo G, Yildiz VO, Uribe AA. The Effect of a Combination Treatment Using Palonosetron, Promethazine, and Dexamethasone on the Prophylaxis of Postoperative Nausea and Vomiting and QTc Interval Duration in Patients Undergoing Craniotomy under General Anesthesia: A Pilot Study. Front Med (Lausanne). 2016 Feb 2;3:1. doi: 10.3389/fmed.2016.00001. eCollection 2016. PubMed PMID: 26870733; PubMed Central PMCID: PMC4735400. 20: Nurulain SM, Ojha S, Shafiullah M, Khan N, Oz M, Sadek B. Protective effects of the antihistamine promethazine aginst acute paraxon-methyl and dicrotophos toxicity in adult rats. Int J Clin Exp Med. 2015 Oct 15;8(10):17891-901. eCollection 2015. PubMed PMID: 26770383; PubMed Central PMCID: PMC4694283.