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MedKoo Cat#: 318562 | Name: Praziquantel
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Description:

WARNING: This product is for research use only, not for human or veterinary use.

Praziquantel is a highly effective anthelmintic against all Schistosoma species and many cestode infestations. Praziquantel is a widely used anti-schistosome drug which has a low cost and a high cure rate of Schistosomiasis.

Chemical Structure

Praziquantel
Praziquantel
CAS#55268-74-1

Theoretical Analysis

MedKoo Cat#: 318562

Name: Praziquantel

CAS#: 55268-74-1

Chemical Formula: C19H24N2O2

Exact Mass: 312.1838

Molecular Weight: 312.41

Elemental Analysis: C, 73.05; H, 7.74; N, 8.97; O, 10.24

Price and Availability

Size Price Availability Quantity
1g USD 90.00 Ready to ship
2g USD 150.00 Ready to ship
5g USD 300.00 Ready to ship
10g USD 450.00 Ready to ship
20g USD 750.00 Ready to ship
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Related CAS #
55268-74-1 57452-98-9 (R isomer)
Synonym
Praziquantel; Biltricide; Droncit; Cesol; Pyquiton; Praziquantel, (+-)-Isomer; Praziquantel, (R)-Isomer; Praziquantel, (S)-Isomer; Pyquiton; Traziquantel;
IUPAC/Chemical Name
2-(cyclohexanecarbonyl)-3,6,7,11b-tetrahydro-1H-pyrazino[2,1-a]isoquinolin-4-one
InChi Key
FSVJFNAIGNNGKK-UHFFFAOYSA-N
InChi Code
InChI=1S/C19H24N2O2/c22-18-13-20(19(23)15-7-2-1-3-8-15)12-17-16-9-5-4-6-14(16)10-11-21(17)18/h4-6,9,15,17H,1-3,7-8,10-13H2
SMILES Code
C1CCC(CC1)C(=O)N2CC3C4=CC=CC=C4CCN3C(=O)C2
Appearance
Solid powder
Purity
>98% (or refer to the Certificate of Analysis)
Shipping Condition
Shipped under ambient temperature as non-hazardous chemical. This product is stable enough for a few weeks during ordinary shipping and time spent in Customs.
Storage Condition
Dry, dark and at 0 - 4 C for short term (days to weeks) or -20 C for long term (months to years).
Solubility
Soluble in DMSO, not in water
Shelf Life
>2 years if stored properly
Drug Formulation
This drug may be formulated in DMSO
Stock Solution Storage
0 - 4 C for short term (days to weeks), or -20 C for long term (months).
HS Tariff Code
2934.99.9001
More Info
Product Data
Product Data
Certificate of Analysis
View CoA: current batch, Lot#A23K09S23
Safety Data Sheet (SDS)
View Safety Data Sheet (SDS)
Instruction
View handling instruction
Biological target:
Praziquantel is a highly effective anthelmintic against all Schistosoma species and many cestode infestations.
In vitro activity:
Praziquantel significantly attenuated CCl4 -induced liver fibrosis by inhibiting the activation of hepatic stellate cells (HSCs) and expression of collagen matrix via enhancement of Smad7 expression, which were confirmed in LX-2, MES13, and NIH3T3 cells in vitro. In contrast, knockdown of Smad7 in LX-2 cells prevented praziquantel-mediated inhibition of LX-2 cell activation and TGF-β1-mediated collagen type I α1 induction, revealing the critical role of Smad7 in the antifibrotic effect of praziquantel during liver fibrosis. Reference: Br J Pharmacol. 2019 Dec;176(24):4666-4680. https://pubmed.ncbi.nlm.nih.gov/31412137/
In vivo activity:
Adult worms from PZQ (praziquantel)-pretreated mice were runtish showing a shorter length, smaller organs and fewer eggs in the uteri of females. Detection of cytokines, NO, 5-HT and hematological indicators showed that PZQ induced immune-physiological changes, including higher levels of NO, IFN-γ and IL-2, and a lower level of TGF-β. No significant difference in the anti-S. japonicum specific antibody levels was observed. The PZQ concentrations in plasma and blood cells 8 and 15 days post-administration were lower than the detection limit. Reference: Acta Trop. 2023 May;241:106874. https://pubmed.ncbi.nlm.nih.gov/36863502/
Solvent mg/mL mM
Solubility
DMF 30.0 96.03
DMSO 44.3 141.91
DMSO:PBS (pH 7.2) (1:4) 0.2 0.64
Ethanol 36.5 116.83
Water 0.1 0.32
Note: There can be variations in solubility for the same chemical from different vendors or different batches from the same vendor. The following factors can affect the solubility of the same chemical: solvent used for crystallization, residual solvent content, polymorphism, salt versus free form, degree of hydration, solvent temperature. Please use the solubility data as a reference only. Warming and sonication will facilitate dissolving. Still have questions? Please contact our Technical Support scientists.

Preparing Stock Solutions

The following data is based on the product molecular weight 312.41 Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which will affect the solvent volumes required to prepare stock solutions.

Recalculate based on batch purity %
Concentration / Solvent Volume / Mass 1 mg 5 mg 10 mg
1 mM 1.15 mL 5.76 mL 11.51 mL
5 mM 0.23 mL 1.15 mL 2.3 mL
10 mM 0.12 mL 0.58 mL 1.15 mL
50 mM 0.02 mL 0.12 mL 0.23 mL
Formulation protocol:
1. Liu J, Kong D, Qiu J, Xie Y, Lu Z, Zhou C, Liu X, Zhang R, Wang Y. Praziquantel ameliorates CCl4 -induced liver fibrosis in mice by inhibiting TGF-β/Smad signalling via up-regulating Smad7 in hepatic stellate cells. Br J Pharmacol. 2019 Dec;176(24):4666-4680. doi: 10.1111/bph.14831. Epub 2019 Dec 29. PMID: 31412137; PMCID: PMC6965681. 2. Eyoh E, McCallum P, Killick J, Amanfo S, Mutapi F, Astier AL. The anthelmintic drug praziquantel promotes human Tr1 differentiation. Immunol Cell Biol. 2019 May;97(5):512-518. doi: 10.1111/imcb.12229. Epub 2019 Jan 30. PMID: 30623486. 3. Shao B, Gui X, Lu Z, Lv R, Li H, Lu K, Hong Y, Fu Z, Jin Y, Lin J, Fei C, Liu J. Praziquantel promotes protection against Schistosoma japonicum infection in mice. Acta Trop. 2023 May;241:106874. doi: 10.1016/j.actatropica.2023.106874. Epub 2023 Mar 1. PMID: 36863502. 4. Wang N, Peng HQ, Gao CZ, Cheng YH, Sun MT, Qu GL, Webster JP, Lu DB. In vivo efficiency of praziquantel treatment of single-sex Schistosoma japonicum aged three months old in mice. Int J Parasitol Drugs Drug Resist. 2022 Dec;20:129-134. doi: 10.1016/j.ijpddr.2022.11.002. Epub 2022 Nov 12. PMID: 36403362; PMCID: PMC9771832.
In vitro protocol:
1. Liu J, Kong D, Qiu J, Xie Y, Lu Z, Zhou C, Liu X, Zhang R, Wang Y. Praziquantel ameliorates CCl4 -induced liver fibrosis in mice by inhibiting TGF-β/Smad signalling via up-regulating Smad7 in hepatic stellate cells. Br J Pharmacol. 2019 Dec;176(24):4666-4680. doi: 10.1111/bph.14831. Epub 2019 Dec 29. PMID: 31412137; PMCID: PMC6965681. 2. Eyoh E, McCallum P, Killick J, Amanfo S, Mutapi F, Astier AL. The anthelmintic drug praziquantel promotes human Tr1 differentiation. Immunol Cell Biol. 2019 May;97(5):512-518. doi: 10.1111/imcb.12229. Epub 2019 Jan 30. PMID: 30623486.
In vivo protocol:
1. Shao B, Gui X, Lu Z, Lv R, Li H, Lu K, Hong Y, Fu Z, Jin Y, Lin J, Fei C, Liu J. Praziquantel promotes protection against Schistosoma japonicum infection in mice. Acta Trop. 2023 May;241:106874. doi: 10.1016/j.actatropica.2023.106874. Epub 2023 Mar 1. PMID: 36863502. 2. Wang N, Peng HQ, Gao CZ, Cheng YH, Sun MT, Qu GL, Webster JP, Lu DB. In vivo efficiency of praziquantel treatment of single-sex Schistosoma japonicum aged three months old in mice. Int J Parasitol Drugs Drug Resist. 2022 Dec;20:129-134. doi: 10.1016/j.ijpddr.2022.11.002. Epub 2022 Nov 12. PMID: 36403362; PMCID: PMC9771832.
1: Zeng X, Feng PK, Li SJ, Lv SQ, Wen ML, Li Y. GNN-DDAS: Drug discovery for identifying anti-schistosome small molecules based on graph neural network. J Comput Chem. 2024 Aug 27. doi: 10.1002/jcc.27490. Epub ahead of print. PMID: 39189298. 2: Nofal AE, Shaaban AM, Ibrahim HM, Abouelmagd F, Mohamed AH. In Vivo Antischistosomicidal and Immunomodulatory Effects of Dietary Supplementation with Taraxacum officinale. J Xenobiot. 2024 Jul 29;14(3):1003-1022. doi: 10.3390/jox14030056. PMID: 39189171. 3: Paubel T, Schneider V, Lenfant M, Blanc Labarre C. A tropical myelitis. Neurol Sci. 2024 Aug 26. doi: 10.1007/s10072-024-07743-x. Epub ahead of print. PMID: 39183258. 4: Degarege A, Levecke B, Negash Y, Animut A, Erko B. Clinical sensitivity and time-to-result of a cascaded pooled testing approach for assessing the prevalence and intensity of Schistosoma haematobium infection. PLoS Negl Trop Dis. 2024 Aug 22;18(8):e0012435. doi: 10.1371/journal.pntd.0012435. Epub ahead of print. PMID: 39173069. 5: Xu J, Wang JY, Huang P, Liu ZH, Wang YX, Zhang RZ, Ma HM, Zhou BY, Ni XY, Xiong CR, Xia CM. Schistosomicidal effects of histone acetyltransferase inhibitors against Schistosoma japonicum juveniles and adult worms in vitro. PLoS Negl Trop Dis. 2024 Aug 19;18(8):e0012428. doi: 10.1371/journal.pntd.0012428. Epub ahead of print. PMID: 39159234. 6: Mulate ST, Nur AM, Tasamma AT, Annose RT, Dawud EM, Ekubazgi KW, Mekonnen HD, Mohammed HY, Hailemeskel MB, Yimer SA. Colonic schistosomiasis mimicking cancer, polyp, and inflammatory bowel disease: Five case reports and review of literature. World J Gastrointest Endosc. 2024 Aug 16;16(8):472-482. doi: 10.4253/wjge.v16.i8.472. PMID: 39155995; PMCID: PMC11325876. 7: Sangkam W, Arunsan P, Pechdee P, Boonsuya A, Thanchonnang C, Chatdumrong W, Rattanapitoon NK, Rattanapitoon SK. Anthelmintic activity and pathophysiological effect of anthelmintic drugs against carcinogenic liver fluke, Opisthorchis viverrini. Trop Biomed. 2024 Jun 1;41(2):196-205. doi: 10.47665/tb.41.2.010. PMID: 39154273. 8: Dewi DAR, Irawati Tjahjo Widuri L, Allatib A, Athallah AA, Balga AI, Arkania N, Nadhira F, Wiliantari NM, Ulfa F. Effectiveness of the Antiparasitic Combination of Albendazole and Praziquantel As Compared With Albendazole Monotherapy in the Treatment of Neurocysticercosis in Children: A Systematic Review and Meta-Analysis. Cureus. 2024 Jul 15;16(7):e64617. doi: 10.7759/cureus.64617. PMID: 39149676; PMCID: PMC11324961. 9: El-Attar NA, El-Sawi MR, El-Shabasy EA. The synergistic effect of Ficus carica nanoparticles and Praziquantel on mice infected by Schistosoma mansoni cercariae. Sci Rep. 2024 Aug 15;14(1):18944. doi: 10.1038/s41598-024-68957-9. PMID: 39147839; PMCID: PMC11327331. 10: Saha S, Mondal C, Mandal S, Ray MS, Lyndem LM. In vitro anthelmintic efficacy of Ferulic and Sinapic acid against zoonotic cestode Hymenolepis diminuta (Rudolphi, 1819). J Parasit Dis. 2024 Sep;48(3):501-513. doi: 10.1007/s12639-024-01689-9. Epub 2024 May 22. PMID: 39145371; PMCID: PMC11319579. 11: Nafie EH, Abou-Gamra MM, Mossalem HS, Sarhan RM, Hammam OA, Nasr SM, Anwar MM. Evaluation of the prophylactic and therapeutic efficacies of mucus and tissue nucleoproteins extracted from Biomphalaria alexandrina snails on schistosomiasis mansoni. J Parasit Dis. 2024 Sep;48(3):551-569. doi: 10.1007/s12639-024-01692-0. Epub 2024 Jun 26. PMID: 39145357; PMCID: PMC11319553. 12: Jiang H, Zhou J, Cai X, Hu B, Wang H, Fu C, Xu N, Gong Y, Tong Y, Yin J, Huang J, Wang J, Jiang Q, Liang S, Zhou Y. Impact of historical disease conditions on mortality and life expectancy in patients with advanced schistosomiasis in Hunan Province, China. Trans R Soc Trop Med Hyg. 2024 Aug 15:trae052. doi: 10.1093/trstmh/trae052. Epub ahead of print. PMID: 39143751. 13: Rodríguez-Molino P, González Martínez S, Bustamante Amador J, Mellado-Sola I, Montes Martín L, Falces-Romero I, García López-Hortelano M, Hurtado-Gallego J, Mellado MJ, Grasa C, Sainz T. Schistosomiasis in migrant children and adolescents in a paediatric tropical referral unit in Spain: diagnosis and long- term management challenges. Eur J Pediatr. 2024 Aug 15. doi: 10.1007/s00431-024-05623-2. Epub ahead of print. PMID: 39143347. 14: Mian MY, Sharmin D, Mondal P, Belayet JB, Hossain MM, McCusker P, Ryan KT, Fedorov AY, Green HA, Ericksen SS, Zamanian M, Tiruveedhula VVNPB, Cook JM, Chan JD. Development of non-sedating benzodiazepines with in vivo antischistosomal activity. Antimicrob Agents Chemother. 2024 Aug 13:e0036924. doi: 10.1128/aac.00369-24. Epub ahead of print. PMID: 39136467. 15: Comelli A, Angheben A, Albonico M, Calleri G, Zammarchi L, Napoli C, Marrone R. Schistosomiasis in Migrants: Bridging the Gap in Italy's Treatment Guidelines and Access. J Travel Med. 2024 Aug 10:taae107. doi: 10.1093/jtm/taae107. Epub ahead of print. PMID: 39126368. 16: Abbas I, Tamponi C, Madau G, Cavallo L, Varcasia A, Scala A. Treatment and management of coenurosis by Taenia multiceps: field data from outbreaks in endemic regions and literature review. Parasit Vectors. 2024 Aug 9;17(1):335. doi: 10.1186/s13071-024-06430-2. PMID: 39123250; PMCID: PMC11312392. 17: Alajab MB, Rafei A, Abdo AE. Schistosomal colitis mimicking inflammatory bowel disease: a case report from Sudan. Ann Med Surg (Lond). 2024 Jun 21;86(8):4895-4897. doi: 10.1097/MS9.0000000000002300. PMID: 39118742; PMCID: PMC11305794. 18: Tielemans E, Rautenbach C, Khumalo Z, Beugnet F. Efficacy of a topical combination of esafoxolaner, eprinomectin and praziquantel against Amblyomma maculatum infestations in cats. Parasite. 2024;31:44. doi: 10.1051/parasite/2024044. Epub 2024 Aug 7. PMID: 39109981; PMCID: PMC11305115. 19: Sassi S, Touarsa F, Jaradat T, Arkha Y, El Ouazzani H, Cherradi N. Intramedullary spinal schistosomiasis: A case report and review of the literature. Int J Surg Case Rep. 2024 Jul 31;122:110103. doi: 10.1016/j.ijscr.2024.110103. Epub ahead of print. PMID: 39094321; PMCID: PMC11342890. 20: Di Cesare A, Veronesi F, Crisi PE, Colombo M, Morelli S, Vignoli M, Rigamonti G, Iorio R, Tielemans E, Beugnet F, Gamblin C, Traversa D. Clinical efficacy of a parasiticide formulation containing eprinomectin, esafoxolaner and praziquantel (NexGard® Combo) in the treatment of natural feline aelurostrongylosis and troglostrongylosis. Vet Parasitol. 2024 Jul 22;331:110271. doi: 10.1016/j.vetpar.2024.110271. Epub ahead of print. PMID: 39089177.