Synonym
(R)-Praziquantel; R-Praziquantel; (R)-PZQ; (R) PZQ; (R)PZQ; Arpraziquantel l-Praziquantel;
IUPAC/Chemical Name
(11bR)-2-(Cyclohexanecarbonyl)-3,6,7,11b-tetrahydro-1H-pyrazino[2,1-a]isoquinolin-4-one
InChi Key
FSVJFNAIGNNGKK-KRWDZBQOSA-N
InChi Code
InChI=1S/C19H24N2O2/c22-18-13-20(19(23)15-7-2-1-3-8-15)12-17-16-9-5-4-6-14(16)10-11-21(17)18/h4-6,9,15,17H,1-3,7-8,10-13H2/t17-/m0/s1
SMILES Code
O=C1CN(C(C2CCCCC2)=O)C[C@]3([H])N1CCC4=C3C=CC=C4
Purity
>98% (or refer to the Certificate of Analysis)
Shipping Condition
Shipped under ambient temperature as non-hazardous chemical. This product is stable enough for a few weeks during ordinary shipping and time spent in Customs.
Storage Condition
Dry, dark and at 0 - 4 C for short term (days to weeks) or -20 C for long term (months to years).
Solubility
Soluble in DMSO
Shelf Life
>2 years if stored properly
Drug Formulation
This drug may be formulated in DMSO
Stock Solution Storage
0 - 4 C for short term (days to weeks), or -20 C for long term (months).
HS Tariff Code
2934.99.9001
Preparing Stock Solutions
The following data is based on the
product
molecular weight
312.41
Batch specific molecular weights may vary
from batch to batch
due to the degree of hydration, which will
affect the solvent
volumes required to prepare stock solutions.
| Concentration / Solvent Volume / Mass |
1 mg |
5 mg |
10 mg |
| 1 mM |
1.15 mL |
5.76 mL |
11.51 mL |
| 5 mM |
0.23 mL |
1.15 mL |
2.3 mL |
| 10 mM |
0.12 mL |
0.58 mL |
1.15 mL |
| 50 mM |
0.02 mL |
0.12 mL |
0.23 mL |
1: Bowman DD, Drake J. Examination of the "susceptibility gap" in the treatment of canine heartworm infection. Parasit Vectors. 2017 Nov 9;10(Suppl 2):513. doi: 10.1186/s13071-017-2433-9. Review. PubMed PMID: 29143689; PubMed Central PMCID: PMC5688481.
2: da Silva VBR, Campos BRKL, de Oliveira JF, Decout JL, do Carmo Alves de Lima M. Medicinal chemistry of antischistosomal drugs: Praziquantel and oxamniquine. Bioorg Med Chem. 2017 Jul 1;25(13):3259-3277. doi: 10.1016/j.bmc.2017.04.031. Epub 2017 Apr 27. Review. PubMed PMID: 28495384.
3: Bustinduy AL, Wright S, Joekes EC, Kabatereine NB, Reinhard-Rupp J, King CH, Stothard JR. One hundred years of neglect in paediatric schistosomiasis. Parasitology. 2017 Oct;144(12):1613-1623. doi: 10.1017/S0031182017000014. Epub 2017 Mar 1. Review. PubMed PMID: 28245890.
4: Price A, Verma A, Welfare W. Are health education interventions effective for the control and prevention of urogenital schistosomiasis in sub-Saharan Africa? A systematic review. Trans R Soc Trop Med Hyg. 2015 Apr;109(4):239-44. doi: 10.1093/trstmh/trv008. Epub 2015 Feb 10. Review. PubMed PMID: 25669840.
5: Olliaro P, Delgado-Romero P, Keiser J. The little we know about the pharmacokinetics and pharmacodynamics of praziquantel (racemate and R-enantiomer). J Antimicrob Chemother. 2014 Apr;69(4):863-70. doi: 10.1093/jac/dkt491. Epub 2014 Jan 2. Review. PubMed PMID: 24390933.
6: Xiao SH, Keiser J, Chen MG, Tanner M, Utzinger J. Research and development of antischistosomal drugs in the People's Republic of China a 60-year review. Adv Parasitol. 2010;73:231-95. doi: 10.1016/S0065-308X(10)73009-8. Review. PubMed PMID: 20627145.
7: Papanikolaou A. Osseous hydatid disease. Trans R Soc Trop Med Hyg. 2008 Mar;102(3):233-8. Epub 2007 Nov 9. Review. PubMed PMID: 17996916.
8: Carod-Artal FJ. Neurological complications of Schistosoma infection. Trans R Soc Trop Med Hyg. 2008 Feb;102(2):107-16. Epub 2007 Oct 1. Review. PubMed PMID: 17905371.
9: Olsen A. Efficacy and safety of drug combinations in the treatment of schistosomiasis, soil-transmitted helminthiasis, lymphatic filariasis and onchocerciasis. Trans R Soc Trop Med Hyg. 2007 Aug;101(8):747-58. Epub 2007 May 3. Review. PubMed PMID: 17481681.
10: Gutteridge WE. TDR collaboration with the pharmaceutical industry. Trans R Soc Trop Med Hyg. 2006 Dec;100 Suppl 1:S21-5. Epub 2006 May 26. Review. PubMed PMID: 16730039.
11: Strickland GT. Liver disease in Egypt: hepatitis C superseded schistosomiasis as a result of iatrogenic and biological factors. Hepatology. 2006 May;43(5):915-22. Review. PubMed PMID: 16628669.
12: Doenhoff MJ, Kusel JR, Coles GC, Cioli D. Resistance of Schistosoma mansoni to praziquantel: is there a problem? Trans R Soc Trop Med Hyg. 2002 Sep-Oct;96(5):465-9. Review. PubMed PMID: 12474468.
13: Cook GC. Taeniasis and cysticercosis. J R Soc Med. 1998 Oct;91(10):534-5. Review. PubMed PMID: 10070374; PubMed Central PMCID: PMC1296913.
14: Strickland GT, Abdel-Wahab MF. Abdominal ultrasonography for assessing morbidity from schistosomiasis. 1. Community studies. Trans R Soc Trop Med Hyg. 1993 Mar-Apr;87(2):132-4. Review. PubMed PMID: 8337708.
15: Pejaver RK. Cerebral neurocysticercosis--case report and review. J R Soc Health. 1992 Aug;112(4):170-1. Review. PubMed PMID: 1433148.
16: Cook GC. The clinical significance of gastrointestinal helminths--a review. Trans R Soc Trop Med Hyg. 1986;80(5):675-85. Review. PubMed PMID: 3299885.
