CCT 241533 dihydrochloride is a potent Chk2 inhibitor (IC50 = 3 nM). It shows >63-fold selectivity for Chk1 over Chk2 and a panel of 84 other kinases. CCT 241533 dihydrochloride inhibits Chk2 activation in response to etoposide-induced DNA damage in HT29 cells and blocks ionizing radiation-induced apoptosis of mouse thymocytes.
MedKoo Cat#: 523104
Name: CCT-241533 HCl
CAS#: 1431697-96-9 (HCl)
Chemical Formula: C23H28ClFN4O4
Exact Mass: 0.0000
Molecular Weight: 478.95
Elemental Analysis: C, 57.68; H, 5.89; Cl, 7.40; F, 3.97; N, 11.70; O, 13.36
The following data is based on the product molecular weight 478.95 Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which will affect the solvent volumes required to prepare stock solutions.
| Concentration / Solvent Volume / Mass | 1 mg | 5 mg | 10 mg |
|---|---|---|---|
| 1 mM | 1.15 mL | 5.76 mL | 11.51 mL |
| 5 mM | 0.23 mL | 1.15 mL | 2.3 mL |
| 10 mM | 0.12 mL | 0.58 mL | 1.15 mL |
| 50 mM | 0.02 mL | 0.12 mL | 0.23 mL |
