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MedKoo Cat#: 318159 | Name: Lomefloxacin Hydrochloride
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Description:

WARNING: This product is for research use only, not for human or veterinary use.

Lomefloxacin is a fluoroquinolone antibiotic that is commonly used to treat bacterial infections, including bronchitis and urinary tract infections. It is used as a pre-operative prophylactic to prevent urinary tract infection caused by S. pneumoniae, E. coli, and K. pneumoniae. It is used to induce genomic instability in mice and modification of the kinetics of growth of Gram-negative bacteria.

Chemical Structure

Lomefloxacin Hydrochloride
Lomefloxacin Hydrochloride
CAS#98079-52-8 (HCl)

Theoretical Analysis

MedKoo Cat#: 318159

Name: Lomefloxacin Hydrochloride

CAS#: 98079-52-8 (HCl)

Chemical Formula: C17H20ClF2N3O3

Exact Mass: 0.0000

Molecular Weight: 387.81

Elemental Analysis: C, 52.65; H, 5.20; Cl, 9.14; F, 9.80; N, 10.84; O, 12.38

Price and Availability

Size Price Availability Quantity
5g USD 250.00 2 weeks
25g USD 650.00 2 weeks
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Related CAS #
98079-51-7 (free base) 98079-52-8 (HCl)
Synonym
Lomefloxacin hydrochloride; Lomefloxacin HCl; Maxaquin; Ny-198; Bareon; Pharmacia Brand 1 of Lomefloxacin Hydrochloride; Pharmacia Brand 2 of Lomefloxacin Hydrochloride; SC 4711; SC-4711;
IUPAC/Chemical Name
1-ethyl-6,8-difluoro-7-(3-methylpiperazin-1-yl)-4-oxoquinoline-3-carboxylic acid;hydrochloride
InChi Key
KXEBLAPZMOQCKO-UHFFFAOYSA-N
InChi Code
InChI=1S/C17H19F2N3O3.ClH/c1-3-21-8-11(17(24)25)16(23)10-6-12(18)15(13(19)14(10)21)22-5-4-20-9(2)7-22;/h6,8-9,20H,3-5,7H2,1-2H3,(H,24,25);1H
SMILES Code
CCN1C=C(C(=O)C2=CC(=C(C(=C21)F)N3CCNC(C3)C)F)C(=O)O.Cl
Appearance
Solid powder
Purity
>98% (or refer to the Certificate of Analysis)
Shipping Condition
Shipped under ambient temperature as non-hazardous chemical. This product is stable enough for a few weeks during ordinary shipping and time spent in Customs.
Storage Condition
Dry, dark and at 0 - 4 C for short term (days to weeks) or -20 C for long term (months to years).
Solubility
Soluble in DMSO, not in water
Shelf Life
>2 years if stored properly
Drug Formulation
This drug may be formulated in DMSO
Stock Solution Storage
0 - 4 C for short term (days to weeks), or -20 C for long term (months).
HS Tariff Code
2934.99.9001
More Info
Product Data
Product Data
Instruction
View handling instruction
Biological target:
Lomefloxacin (SC47111A) hydrochloride is a broad-spectrum quinolone antibiotic, with antimicrobial activity.
In vitro activity:
Lomefloxacin decreases the cell viability in a dose- and time-dependent manner. For COLO829 cells treated with the drug for 24, 48, and 72 h, the values of IC50 were found to be 0.51, 0.33, and 0.25 mmol/L, respectively. Reference: Int J Mol Sci. 2017 Oct 20;18(10):2194. https://pubmed.ncbi.nlm.nih.gov/29053584/
In vivo activity:
The mice were treated with sparfloxacin, lomefloxacin, or a quinoline derivative orally followed by the irradiation of simulated sunlight, and resulting phototoxic reactions of the ears were assessed. In the in vivo test, sparfloxacin and lomefloxacin exhibited positive skin reaction in mice, but the quinoline derivative did not. The results of in vivo phototoxicity test in the mice coincided with phototoxic potential of these drugs in humans. Reference: J Toxicol Sci. 2010 Feb;35(1):97-100. https://pubmed.ncbi.nlm.nih.gov/20118629/
Solvent mg/mL mM
Solubility
DMSO 1.0 2.58
PBS (pH 7.2) 2.0 5.16
Water 6.6 16.94
Note: There can be variations in solubility for the same chemical from different vendors or different batches from the same vendor. The following factors can affect the solubility of the same chemical: solvent used for crystallization, residual solvent content, polymorphism, salt versus free form, degree of hydration, solvent temperature. Please use the solubility data as a reference only. Warming and sonication will facilitate dissolving. Still have questions? Please contact our Technical Support scientists.

Preparing Stock Solutions

The following data is based on the product molecular weight 387.81 Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which will affect the solvent volumes required to prepare stock solutions.

Recalculate based on batch purity %
Concentration / Solvent Volume / Mass 1 mg 5 mg 10 mg
1 mM 1.15 mL 5.76 mL 11.51 mL
5 mM 0.23 mL 1.15 mL 2.3 mL
10 mM 0.12 mL 0.58 mL 1.15 mL
50 mM 0.02 mL 0.12 mL 0.23 mL
Formulation protocol:
1. Beberok A, Wrześniok D, Szlachta M, Rok J, Rzepka Z, Respondek M, Buszman E. Lomefloxacin Induces Oxidative Stress and Apoptosis in COLO829 Melanoma Cells. Int J Mol Sci. 2017 Oct 20;18(10):2194. doi: 10.3390/ijms18102194. PMID: 29053584; PMCID: PMC5666875. 2. Beberok A, Otręba M, Wrześniok D, Buszman E. Cytotoxic effect of lomefloxacin in culture of human epidermal melanocytes. Pharmacol Rep. 2013;65(3):689-99. doi: 10.1016/s1734-1140(13)71047-8. PMID: 23950592. 3. Matsumoto N, Akimoto A, Kawashima H, Kim S. Comparative study of skin phototoxicity with three drugs by an in vivo mouse model. J Toxicol Sci. 2010 Feb;35(1):97-100. doi: 10.2131/jts.35.97. PMID: 20118629.
In vitro protocol:
1. Beberok A, Wrześniok D, Szlachta M, Rok J, Rzepka Z, Respondek M, Buszman E. Lomefloxacin Induces Oxidative Stress and Apoptosis in COLO829 Melanoma Cells. Int J Mol Sci. 2017 Oct 20;18(10):2194. doi: 10.3390/ijms18102194. PMID: 29053584; PMCID: PMC5666875. 2. Beberok A, Otręba M, Wrześniok D, Buszman E. Cytotoxic effect of lomefloxacin in culture of human epidermal melanocytes. Pharmacol Rep. 2013;65(3):689-99. doi: 10.1016/s1734-1140(13)71047-8. PMID: 23950592.
In vivo protocol:
1. Matsumoto N, Akimoto A, Kawashima H, Kim S. Comparative study of skin phototoxicity with three drugs by an in vivo mouse model. J Toxicol Sci. 2010 Feb;35(1):97-100. doi: 10.2131/jts.35.97. PMID: 20118629.
1: Wei Y, Du S, Ito Y. Enantioseparation of lomefloxacin hydrochloride by high-speed counter-current chromatography using sulfated-β-cyclodextrin as a chiral selector. J Chromatogr B Analyt Technol Biomed Life Sci. 2010 Oct 15;878(28):2937-41. doi: 10.1016/j.jchromb.2010.08.030. Epub 2010 Sep 15. PubMed PMID: 20837406; PubMed Central PMCID: PMC2950249. 2: Sultana N, Arayne MS, Furqan H. In vitro availability of lomefloxacin hydrochloride in presence of essential and trace elements. Pak J Pharm Sci. 2005 Jul;18(3):59-65. PubMed PMID: 16380347. 3: Derevianko II, Lopatkin NA, Khodyreva LA, Kondrat'eva EM. [The use of Maxaquin (lomefloxacin hydrochloride) in the treatment of nonspecific inflammatory diseases and in the prevention of surgical interventions in urology]. Urol Nefrol (Mosk). 1998 Sep-Oct;(5):14-8. Russian. PubMed PMID: 9820038. 4: Yasueda S, Higashiyama M, Yamaguchi M, Isowaki A, Ohtori A. Corneal critical barrier against the penetration of dexamethasone and lomefloxacin hydrochloride: evaluation by the activation energy for drug partition and diffusion in cornea. Drug Dev Ind Pharm. 2007 Aug;33(8):805-11. PubMed PMID: 17729097. 5: Bai ZZ, Zhang QS, Sheng LS. [Study on photodegradation kinetics of lomefloxacin hydrochloride aqueous solution]. Yao Xue Xue Bao. 2001 Mar;36(3):210-4. Chinese. PubMed PMID: 12580090. 6: Arata J, Horio T, Soejima R, Ohara K. Photosensitivity reactions caused by lomefloxacin hydrochloride: a multicenter survey. Antimicrob Agents Chemother. 1998 Dec;42(12):3141-5. PubMed PMID: 9835505; PubMed Central PMCID: PMC106013. 7: Kuznetsovoĭ SM. [Lomefloxacin hydrochloride (Maxaquin), a long-acting fluoroquinolone (information for specialists)]. Antibiot Khimioter. 1998;43(2):40-1. Russian. PubMed PMID: 9551172.

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