Synonym
Lomefloxacin; CCRIS6305; CCRIS-6305; CCRIS 6305; DM10; DM 10; DM-10
IUPAC/Chemical Name
3-Quinolinecarboxylic acid, 1,4-dihydro-6,8-difluoro-1-ethyl-7-(3-methyl-1-piperazinyl)-4-oxo-
InChi Key
ZEKZLJVOYLTDKK-UHFFFAOYSA-N
InChi Code
InChI=1S/C17H19F2N3O3/c1-3-21-8-11(17(24)25)16(23)10-6-12(18)15(13(19)14(10)21)22-5-4-20-9(2)7-22/h6,8-9,20H,3-5,7H2,1-2H3,(H,24,25)
SMILES Code
O=C(C1=CN(CC)C2=C(C=C(F)C(N3CC(C)NCC3)=C2F)C1=O)O
Purity
>98% (or refer to the Certificate of Analysis)
Shipping Condition
Shipped under ambient temperature as non-hazardous chemical. This product is stable enough for a few weeks during ordinary shipping and time spent in Customs.
Storage Condition
Dry, dark and at 0 - 4 C for short term (days to weeks) or -20 C for long term (months to years).
Solubility
To be determined
Shelf Life
>2 years if stored properly
Drug Formulation
To be determined
Stock Solution Storage
0 - 4 C for short term (days to weeks), or -20 C for long term (months).
HS Tariff Code
2934.99.9001
Preparing Stock Solutions
The following data is based on the
product
molecular weight
351.35
Batch specific molecular weights may vary
from batch to batch
due to the degree of hydration, which will
affect the solvent
volumes required to prepare stock solutions.
| Concentration / Solvent Volume / Mass |
1 mg |
5 mg |
10 mg |
| 1 mM |
1.15 mL |
5.76 mL |
11.51 mL |
| 5 mM |
0.23 mL |
1.15 mL |
2.3 mL |
| 10 mM |
0.12 mL |
0.58 mL |
1.15 mL |
| 50 mM |
0.02 mL |
0.12 mL |
0.23 mL |
1: Al-Wabli RI. Lomefloxacin. Profiles Drug Subst Excip Relat Methodol. 2017;42:193-240. doi: 10.1016/bs.podrm.2017.02.004. Epub 2017 Mar 31. PMID: 28431777.
2: Freeman CD, Nicolau DP, Belliveau PP, Nightingale CH. Lomefloxacin clinical pharmacokinetics. Clin Pharmacokinet. 1993 Jul;25(1):6-19. doi: 10.2165/00003088-199325010-00002. PMID: 8394795.
3: Eljaaly K, Alkhalaf A, Alhifany AA, Alshibani M. Photosensitivity induced by lomefloxacin versus other fluoroquinolones: A meta-analysis. J Infect Chemother. 2020 Jun;26(6):535-539. doi: 10.1016/j.jiac.2020.01.005. Epub 2020 Feb 17. PMID: 32081646.
4: Gao M, Li L, Lu S, Liu Q, He H. Silver nanoparticles for the visual detection of lomefloxacin in the presence of cystine. Spectrochim Acta A Mol Biomol Spectrosc. 2018 Dec 5;205:72-78. doi: 10.1016/j.saa.2018.05.072. Epub 2018 May 21. PMID: 30007902.
5: Beberok A, Rzepka Z, Rok J, Banach K, Wrześniok D. UVA Radiation Enhances Lomefloxacin-Mediated Cytotoxic, Growth-Inhibitory and Pro-Apoptotic Effect in Human Melanoma Cells through Excessive Reactive Oxygen Species Generation. Int J Mol Sci. 2020 Nov 25;21(23):8937. doi: 10.3390/ijms21238937. PMID: 33255659; PMCID: PMC7728064.
6: Luo T, Chen J, Li X, Zhang S, Yao H, Peijnenburg WJGM. Effects of lomefloxacin on survival, growth and reproduction of Daphnia magna under simulated sunlight radiation. Ecotoxicol Environ Saf. 2018 Dec 30;166:63-70. doi: 10.1016/j.ecoenv.2018.09.067. Epub 2018 Sep 21. PMID: 30248562.
7: Beberok A, Wrześniok D, Szlachta M, Rok J, Rzepka Z, Respondek M, Buszman E. Lomefloxacin Induces Oxidative Stress and Apoptosis in COLO829 Melanoma Cells. Int J Mol Sci. 2017 Oct 20;18(10):2194. doi: 10.3390/ijms18102194. PMID: 29053584; PMCID: PMC5666875.
8: El-Shazly KA, El-Latif AA, Abdo W, El-Morsey A, El-Aziz MIA, El-Mogazy H. The anticoccidial activity of the fluoroquinolone lomefloxacin against experimental Eimeria tenella infection in broiler chickens. Parasitol Res. 2020 Jun;119(6):1955-1968. doi: 10.1007/s00436-020-06692-6. Epub 2020 May 13. PMID: 32399722.
9: Wadworth AN, Goa KL. Lomefloxacin. A review of its antibacterial activity, pharmacokinetic properties and therapeutic use. Drugs. 1991 Dec;42(6):1018-60. doi: 10.2165/00003495-199142060-00009. Erratum in: Drugs 1992 Jul;44(1):8. PMID: 1724637.
10: Symonds WT, Nix DE. Lomefloxacin and temafloxacin: two new fluoroquinolone antimicrobials. Clin Pharm. 1992 Sep;11(9):753-66. PMID: 1325892.
