Haloprogin | CAS#777-11-7 | Antifungal Agent

MedKoo Cat#: 317988 | Name: Haloprogin

Description:

WARNING: This product is for research use only, not for human or veterinary use.

Haloprogin is an antifungal agent used as a topical cream to treat athlete's foot and other fungal infections. It is marketed in creams under the trade names Halotex, Mycanden, Mycilan, and Polik. It was marketed over the counter primarily to treat tinea infections of the skin. The mechanism of action is unknown.

Chemical Structure

Haloprogin

CAS#777-11-7

Theoretical Analysis

MedKoo Cat#: 317988

Name: Haloprogin

CAS#: 777-11-7

Chemical Formula: C9H4Cl3IO

Exact Mass: 359.8372

Molecular Weight: 361.39

Elemental Analysis: C, 29.91; H, 1.12; Cl, 29.43; I, 35.12; O, 4.43

Price and Availability

This product is currently not in stock but may be available through custom synthesis. To ensure cost efficiency, the minimum order quantity is 1 gram. The estimated lead time is 2 to 4 months, with pricing dependent on the complexity of the synthesis (typically high for intricate chemistries). Quotes for quantities below 1 gram will not be provided. To request a quote, please click the button below. Note: If this product becomes available in stock in the future, pricing will be listed accordingly.

Bulk Inquiry

Related CAS #

No Data

Synonym

Haloprogin; Mycanden; Halotex; Mycilan; Polik; Haloproginum; Théraplix Brand of Haloprogin; Westwood Squibb brand of haloprogin;

IUPAC/Chemical Name

1,2,4-trichloro-5-(3-iodoprop-2-ynoxy)benzene

InChi Key

CTETYYAZBPJBHE-UHFFFAOYSA-N

InChi Code

InChI=1S/C9H4Cl3IO/c10-6-4-8(12)9(5-7(6)11)14-3-1-2-13/h4-5H,3H2

SMILES Code

C1=C(C(=CC(=C1Cl)Cl)Cl)OCC#CI

Appearance

Solid powder

Purity

>98% (or refer to the Certificate of Analysis)

Shipping Condition

Shipped under ambient temperature as non-hazardous chemical. This product is stable enough for a few weeks during ordinary shipping and time spent in Customs.

Storage Condition

Dry, dark and at 0 - 4 C for short term (days to weeks) or -20 C for long term (months to years).

Solubility

Soluble in DMSO, not in water

Shelf Life

>2 years if stored properly

Drug Formulation

This drug may be formulated in DMSO

Stock Solution Storage

0 - 4 C for short term (days to weeks), or -20 C for long term (months).

HS Tariff Code

2934.99.9001

More Info

Instruction

View handling instruction

Preparing Stock Solutions

The following data is based on the product molecular weight 361.39 Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which will affect the solvent volumes required to prepare stock solutions.

Concentration / Solvent Volume / Mass	1 mg	5 mg	10 mg
1 mM	1.15 mL	5.76 mL	11.51 mL
5 mM	0.23 mL	1.15 mL	2.3 mL
10 mM	0.12 mL	0.58 mL	1.15 mL
50 mM	0.02 mL	0.12 mL	0.23 mL

1: Qadripur SA. [Antimycotic therapy. 2. Antimycotic chemotherapeutic agents: imidazole derivatives, tolciclate, haloprogin, ciclopiroxolamin]. Fortschr Med. 1983 Mar 10;101(9):355-63. German. PubMed PMID: 6303928. 2: Langsadl L, Jedlickova Z. Sensitivity of strains of Candida albicans to jaritin, haloprogin, clotrimazole and miconazole. Postgrad Med J. 1979 Sep;55(647):695-6. PubMed PMID: 392487; PubMed Central PMCID: PMC2425642. 3: Clayton YM, Gange RW, Macdonald DM, Carruthers JA. A clinical double-blind trial of topical haloprogin and miconazole against superficial fungal infections. Clin Exp Dermatol. 1979 Mar;4(1):65-73. PubMed PMID: 376192. 4: Weitgasser H. [Clinical and myocological study of the antifungal agent haloprogin]. Mykosen. 1977 Jan;20(1):15-24. German. PubMed PMID: 321954. 5: Rudolph RL. Allergic contact dermatitis caused by haloprogin. Arch Dermatol. 1975 Nov;111(11):1487-8. PubMed PMID: 1242878. 6: de Luca M, Argenziano G. [Haloprogin, a new drug for the local treatment of dermatomycoses]. Mykosen. 1975 May;18(5):239-44. German. PubMed PMID: 1174260. 7: Hughes WT, Feldman S, Hermann HW. Safety of megadosage haloprogin. Arch Dermatol. 1974 Dec;110(6):926-8. PubMed PMID: 4479934. 8: Harrison EF, Zygmunt WA. Haloprogin: mode of action studies in Candida albicans. Can J Microbiol. 1974 Sep;20(9):1241-5. PubMed PMID: 4608935. 9: Haloprogin for tinea. Med Lett Drugs Ther. 1973 Aug 17;15(17):69-70. PubMed PMID: 4740517. 10: Hermann HW. Clinical efficacy studies of haloprogin, a new topical antimicrobial agent. Arch Dermatol. 1972 Dec;106(6):839-42. PubMed PMID: 4565229. 11: Hermann HW. Clinical evaluation of haloprogin. Toxicol Appl Pharmacol. 1972 Dec;23(4):598-605. PubMed PMID: 4264777. 12: Carter VH. A controlled study of haloprogin and tolnaftate in tinea pedis. Curr Ther Res Clin Exp. 1972 Jun;14(6):307-10. PubMed PMID: 4625803. 13: Egere JU, Gugnani HC, Nzelibe FK. Treatment of tropical dermatomycoses with haloprogin. Mykosen. 1981 Jan;24(1):27-32. PubMed PMID: 6894481. 14: Rudolph RI. Haloprogin as treatment for fungal infections. Clin Exp Dermatol. 1979 Dec;4(4):548. PubMed PMID: 161212. 15: Kessler HJ, Buitrago B, Strauss E. Investigations of the fungicidal activity of haloprogin. Mykosen. 1978 May;21(5):138-42. PubMed PMID: 580637. 16: Papa CM. Clotrimazole vs haloprogin in the treatment of tinea cruris. Arch Dermatol. 1978 May;114(5):799-800. PubMed PMID: 580551. 17: Montes LF, Hermann HW. Clinical and antimicrobial effects of haloprogin cream in diaper dermatitis. Cutis. 1978 Mar;21(3):410-2. PubMed PMID: 580233. 18: Klima J. [Clinical experience with 0.5% jaritin ointment and comparison of its effectiveness and tolerance with 1% haloprogin ointment (author's transl)]. Cesk Dermatol. 1977 Oct;52(5):319-23. Czech. PubMed PMID: 146569. 19: VanDersarl JV, Sheppard RH. Clotrimazole vs haloprogin treatment of tinea cruris. Arch Dermatol. 1977 Sep;113(9):1233-5. PubMed PMID: 578400. 20: Berlin AR, Miller OF. Allergic contact dermatitis from ethyl sebacata in haloprogin cream. Arch Dermatol. 1976 Nov;112(11):1563-4. PubMed PMID: 990052.