t-Boc-N-amido-PEG1-acid | CAS# 1260092-44-1 | Boc PEG Linker

MedKoo Cat#: 572097 | Name: t-Boc-N-amido-PEG1-acid

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Description:

WARNING: This product is for research use only, not for human or veterinary use.

t-Boc-N-amido-PEG1-acid is a PEG derivative containing a terminal carboxylic acid and Boc-protected amino group. The hydrophilic PEG spacer increases solubility in aqueous media. The terminal carboxylic acid can react to form a stable amide bond. The Boc group can be deprotected under mild acidic conditions to form the free amine.

Chemical Structure

t-Boc-N-amido-PEG1-acid

CAS#1260092-44-1

Theoretical Analysis

MedKoo Cat#: 572097

Name: t-Boc-N-amido-PEG1-acid

CAS#: 1260092-44-1

Chemical Formula: C10H19NO5

Exact Mass: 233.1263

Molecular Weight: 233.26

Elemental Analysis: C, 51.49; H, 8.21; N, 6.00; O, 34.29

Price and Availability

Size	Price	Availability	Quantity
500mg	USD 360.00
1g	USD 650.00

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Related CAS #

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Synonym

t-Boc-N-amido-PEG1-acid

IUPAC/Chemical Name

3-(2-((tert-butoxycarbonyl)amino)ethoxy)propanoic acid

InChi Key

YGNSGMAPLOVGIU-UHFFFAOYSA-N

InChi Code

InChI=1S/C10H19NO5/c1-10(2,3)16-9(14)11-5-7-15-6-4-8(12)13/h4-7H2,1-3H3,(H,11,14)(H,12,13)

SMILES Code

CC(C)(C)OC(NCCOCCC(O)=O)=O

Appearance

Solid powder

Purity

>98% (or refer to the Certificate of Analysis)

Shipping Condition

Shipped under ambient temperature as non-hazardous chemical. This product is stable enough for a few weeks during ordinary shipping and time spent in Customs.

Storage Condition

Dry, dark and at 0 - 4 C for short term (days to weeks) or -20 C for long term (months to years).

Solubility

Soluble in DMSO

Shelf Life

>3 years if stored properly

Drug Formulation

This drug may be formulated in DMSO

Stock Solution Storage

0 - 4 C for short term (days to weeks), or -20 C for long term (months).

HS Tariff Code

2934.99.03.00

More Info

The hydrophilic PEG spacer increases solubility in aqueous media. The terminal carboxylic acid can be reacted with primary amine groups in the presence of activators (e.g. EDC, or DCC) to form a stable amide bond.

Instruction

View handling instruction

Preparing Stock Solutions

The following data is based on the product molecular weight 233.26 Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which will affect the solvent volumes required to prepare stock solutions.

Concentration / Solvent Volume / Mass	1 mg	5 mg	10 mg
1 mM	1.15 mL	5.76 mL	11.51 mL
5 mM	0.23 mL	1.15 mL	2.3 mL
10 mM	0.12 mL	0.58 mL	1.15 mL
50 mM	0.02 mL	0.12 mL	0.23 mL

1: Zhang P, Huang Y, Liu H, Marquez RT, Lu J, Zhao W, Zhang X, Gao X, Li J, Venkataramanan R, Xu L, Li S. A PEG-Fmoc conjugate as a nanocarrier for paclitaxel. Biomaterials. 2014 Aug;35(25):7146-56. doi: 10.1016/j.biomaterials.2014.04.108. Epub 2014 May 22. PubMed PMID: 24856103; PubMed Central PMCID: PMC4102141. 2: Salmaso S, Bersani S, Scomparin A, Mastrotto F, Scherpfer R, Tonon G, Caliceti P. Tailored PEG for rh-G-CSF analogue site-specific conjugation. Bioconjug Chem. 2009 Jun;20(6):1179-85. doi: 10.1021/bc9000432. PubMed PMID: 19469471.