MedKoo Cat#: 318073 | Name: Isopropamide

Description:

WARNING: This product is for research use only, not for human or veterinary use.

Isopropamide (R5) is a long-acting anticholinergic drug. It is used in the treatment of peptic ulcers and other gastrointestinal disorders involving hyperacidity (gastrointestinal acidosis) and hypermotility. Chemically, it contains a quaternary ammonium group. It is most often provided as an iodide salt, but is also available as a bromide or chloride salt.

Chemical Structure

Isopropamide
Isopropamide
CAS#7492-32-2 (free base)

Theoretical Analysis

MedKoo Cat#: 318073

Name: Isopropamide

CAS#: 7492-32-2 (free base)

Chemical Formula: C23H33N2O+

Exact Mass: 353.2587

Molecular Weight: 353.52

Elemental Analysis: C, 78.14; H, 9.41; N, 7.92; O, 4.53

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Synonym
Isopropamide, Chloroisopropamide, Piaccamide, Priazimide; Dipramid, Dipramide
IUPAC/Chemical Name
4-amino-N,N-diisopropyl-N-methyl-4-oxo-3,3-diphenylbutan-1-aminium
InChi Key
JTPUMZTWMWIVPA-UHFFFAOYSA-O
InChi Code
InChI=1S/C23H32N2O/c1-18(2)25(5,19(3)4)17-16-23(22(24)26,20-12-8-6-9-13-20)21-14-10-7-11-15-21/h6-15,18-19H,16-17H2,1-5H3,(H-,24,26)/p+1
SMILES Code
CC([N+](CCC(C1=CC=CC=C1)(C(N)=O)C2=CC=CC=C2)(C(C)C)C)C
Appearance
Solid powder
Purity
>98% (or refer to the Certificate of Analysis)
Shipping Condition
Shipped under ambient temperature as non-hazardous chemical. This product is stable enough for a few weeks during ordinary shipping and time spent in Customs.
Storage Condition
Dry, dark and at 0 - 4 C for short term (days to weeks) or -20 C for long term (months to years).
Solubility
Soluble in DMSO, not in water
Shelf Life
>2 years if stored properly
Drug Formulation
This drug may be formulated in DMSO
Stock Solution Storage
0 - 4 C for short term (days to weeks), or -20 C for long term (months).
HS Tariff Code
2934.99.9001
More Info
Solvent mg/mL mM
Solubility
Soluble in DMSO, not in water 0.0 100.00
Note: There can be variations in solubility for the same chemical from different vendors or different batches from the same vendor. The following factors can affect the solubility of the same chemical: solvent used for crystallization, residual solvent content, polymorphism, salt versus free form, degree of hydration, solvent temperature. Please use the solubility data as a reference only. Warming and sonication will facilitate dissolving. Still have questions? Please contact our Technical Support scientists.

Preparing Stock Solutions

The following data is based on the product molecular weight 353.52 Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which will affect the solvent volumes required to prepare stock solutions.

Recalculate based on batch purity %
Concentration / Solvent Volume / Mass 1 mg 5 mg 10 mg
1 mM 1.15 mL 5.76 mL 11.51 mL
5 mM 0.23 mL 1.15 mL 2.3 mL
10 mM 0.12 mL 0.58 mL 1.15 mL
50 mM 0.02 mL 0.12 mL 0.23 mL
1: Abbas SS, Zaazaa HE, Abdelkawy M, Abdelrahman MM. Spectrophotometric determination of isopropamide iodide and trifluoperazine hydrochloride in presence of trifluoperazine oxidative degradate. Drug Test Anal. 2010 Apr;2(4):168-81. doi: 10.1002/dta.113. PubMed PMID: 20376832. 2: Das Gupta S, Ghosh AK. Antidotal efficacy of isopropamide iodide in acute fluostigmine poisoning in mice. Pharmazie. 1985 Jul;40(7):499-500. PubMed PMID: 2864706. 3: Gaginella TS, Bass P, Perrin JH, Vallner JJ. Effect of bile salts on partitioning behavior and GI absorption of a quaternary ammonium compound, isopropamide iodide. J Pharm Sci. 1973 Jul;62(7):1121-5. PubMed PMID: 4145953. 4: Oi N, Miyazaki K. [Analyses of drugs and chemicals by infrared absorption spectrocopy. X. Determination of isopropamide in pharmaceutical preparations by compensation method]. Yakugaku Zasshi. 1967 Jun;87(6):739-41. Japanese. PubMed PMID: 4383924. 5: Fiume S. [On the pharmacological effects of an association of haloperidol and isopropamide bromide]. Clin Ter. 1966 Oct 31;39(2):161-6. Italian. PubMed PMID: 5996918. 6: Magnin P, Frere M, Lapeyre B. [Notes on the action of isopropamide during delivery]. Lyon Med. 1966 Apr 3;215(14):973-7. French. PubMed PMID: 4379791. 7: Zieliński M. [Cholinolytic and antihistaminic properties of isopropamide iodide]. Acta Pol Pharm. 1966;23(3):271-5. Polish. PubMed PMID: 4380485. 8: Wambsganss E. [Experimental psychological research with the combined preparation "haloperidol plus isopropamide"]. Psychopharmacologia. 1965 Jan 14;7(1):61-71. German. PubMed PMID: 4378554. 9: WAHL R, KEMPF F. [ISOPROPAMIDE (PRIAMIDE): ITS USE IN CONTRAST RADIOLOGICAL EXAMINATION OF THE COLON]. J Radiol Electrol Med Nucl. 1964 Aug-Sep;45:494-6. French. PubMed PMID: 14200425. 10: GADRAT J, RIBET A, SUDUCA P. [HYPOTONIC DUODENOGRAPHY AFTER INJECTION OF ISOPROPAMIDE]. Arch Mal Appar Dig Mal Nutr. 1963 Nov;52:1176-8. French. PubMed PMID: 14098144. 11: FIERLAFIJN E. [HP 32, COMBINATION OF R 1625 (HALOPERIDOL) AND R 79 (ISOPROPAMIDE IODIDE) IN THE THERAPY OF PSYCHIC AND AUTONOMIC DYSTONIA]. Brux Med. 1963 Sep 29;43:985-8. French. PubMed PMID: 14085979. 12: BLAKE AD Jr. TREATMENT OF GASTROINTESTINAL DISORDERS WITH A COMBINATION OF TRIFLUOPERAZINE AND ISOPROPAMIDE. Clin Med (Northfield). 1963 Aug;70:1461-5. PubMed PMID: 15446040. 13: BARBI G. [Isopropamide-trifluoperazine association in the therapy of gastroenteric and cholecystic disease syndromes]. Minerva Gastroenterol. 1963 Apr-Jun;9:97-100. Italian. PubMed PMID: 13966539. 14: GRAINGER GJ. Isopropamide iodide and antacids in the treatment of acute dyspepsia. Practitioner. 1962 Jun;188:792-4. PubMed PMID: 13901056. 15: PIRINOLI M. [The inhibition of gastric acidity by the action of anticholinergic agents. Comparative study of the action of methantheline bromide and isopropamide iodide on the chlorhydria or normal and ulcerous persons, by means of the carboxylic resin method of cation exchange]. Prensa Med Argent. 1961 Dec 15;48:3356-62. Spanish. PubMed PMID: 14486890. 16: MEEROFF M. [Our experience with an anticholinergic agent with prolonged action: isopropamide iodide]. Sem Med. 1961 Apr 13;118:711-7. Spanish. PubMed PMID: 13768938. 17: CAYER D. The effect of isopropamide iodide (darbid), alone and in combination with prochlorperazine (compazine), on the serum protein-bound iodine. N C Med J. 1959 Aug;20:310-1. PubMed PMID: 13808648. 18: ISOPROPAMIDE iodide. J Am Med Assoc. 1958 Jun 21;167(8):993. PubMed PMID: 13549220. 19: El-Gindy A, El-Zeany B, Awad T, Shabana MM. Spectrophotometric determination of trifluoperazine HCl and isopropamide iodide in binary mixture using second derivative and second derivative of the ratio spectra methods. J Pharm Biomed Anal. 2001 Sep;26(2):203-10. PubMed PMID: 11470197. 20: De Schutter JA, Van den Bossche W, De Moerloose P. Separation and determination of isopropamide iodide in pharmaceutical formulations by reversed-phase ion-pair high-performance liquid chromatography. J Chromatogr. 1986 Sep 24;366:321-8. PubMed PMID: 2877999.