Synonym
Isopropamide iodide; 5579MD; 5579-MD; 5579 MD
IUPAC/Chemical Name
Ammonium, (3-carbamoyl-3,3-diphenylpropyl)diisopropylmethyl-, iodide
InChi Key
BFSMWENDZZIWPW-UHFFFAOYSA-N
InChi Code
InChI=1S/C23H32N2O.HI/c1-18(2)25(5,19(3)4)17-16-23(22(24)26,20-12-8-6-9-13-20)21-14-10-7-11-15-21;/h6-15,18-19H,16-17H2,1-5H3,(H-,24,26);1H
SMILES Code
C[N+](C(C)C)(CCC(C1=CC=CC=C1)(C(N)=O)C2=CC=CC=C2)C(C)C.[I-]
Purity
>95% (or refer to the Certificate of Analysis)
Shipping Condition
Shipped under ambient temperature as non-hazardous chemical. This product is stable enough for a few weeks during ordinary shipping and time spent in Customs.
Storage Condition
Dry, dark and at 0 - 4 C for short term (days to weeks) or -20 C for long term (months to years).
Solubility
Soluble in DMSO
Shelf Life
>2 years if stored properly
Drug Formulation
This drug may be formulated in DMSO
Stock Solution Storage
0 - 4 C for short term (days to weeks), or -20 C for long term (months).
HS Tariff Code
2934.99.9001
|
Solvent |
mg/mL |
mM |
| Solubility |
| Soluble in DMSO |
0.0 |
100.00 |
Note: There can be variations in solubility for the same chemical from different vendors or different batches from the same vendor. The following factors can affect the solubility of the same chemical: solvent used for crystallization, residual solvent content, polymorphism, salt versus free form, degree of hydration, solvent temperature. Please use the solubility data as a reference only. Warming and sonication will facilitate dissolving. Still have questions? Please contact our Technical Support scientists.
Preparing Stock Solutions
The following data is based on the
product
molecular weight
480.43
Batch specific molecular weights may vary
from batch to batch
due to the degree of hydration, which will
affect the solvent
volumes required to prepare stock solutions.
| Concentration / Solvent Volume / Mass |
1 mg |
5 mg |
10 mg |
| 1 mM |
1.15 mL |
5.76 mL |
11.51 mL |
| 5 mM |
0.23 mL |
1.15 mL |
2.3 mL |
| 10 mM |
0.12 mL |
0.58 mL |
1.15 mL |
| 50 mM |
0.02 mL |
0.12 mL |
0.23 mL |
1: ISOPROPAMIDE iodide. J Am Med Assoc. 1958 Jun 21;167(8):993. PMID: 13549220.
2: Gaginella TS, Bass P, Perrin JH, Vallner JJ. The absorption and distribution of isopropamide iodide in the rat. J Pharm Pharmacol. 1973 Mar;25(3):270-1. doi: 10.1111/j.2042-7158.1973.tb10641.x. PMID: 4146334.
3: Abbas SS, Zaazaa HE, Abdelkawy M, Abdelrahman MM. Spectrophotometric determination of isopropamide iodide and trifluoperazine hydrochloride in presence of trifluoperazine oxidative degradate. Drug Test Anal. 2010 Apr;2(4):168-81. doi: 10.1002/dta.113. PMID: 20376832.
4: SEEHERMAN R. Isopropamide iodide: a long-acting anticholinergic. Del Med J. 1957 Oct;29(10):265-9. PMID: 13473394.
5: McCarthy DM, Hyman PE. Effect of isopropamide on response to oral cimetidine in patients with Zollinger--Ellison syndrome. Dig Dis Sci. 1982 Apr;27(4):353-9. doi: 10.1007/BF01296756. PMID: 6121690.
6: Gaginella TS, Bass P, Perrin JH, Vallner JJ. Effect of bile salts on partitioning behavior and GI absorption of a quaternary ammonium compound, isopropamide iodide. J Pharm Sci. 1973 Jul;62(7):1121-5. doi: 10.1002/jps.2600620713. PMID: 4145953.
7: Zieliński M. Cholinolityczne i przeciwhistaminowe działanie jodku izopropamidu [Cholinolytic and antihistaminic properties of isopropamide iodide]. Acta Pol Pharm. 1966;23(3):271-5. Polish. PMID: 4380485.
8: De Schutter JA, Van den Bossche W, De Moerloose P. Separation and determination of isopropamide iodide in pharmaceutical formulations by reversed- phase ion-pair high-performance liquid chromatography. J Chromatogr. 1986 Sep 24;366:321-8. doi: 10.1016/s0021-9673(01)93479-x. PMID: 2877999.
9: SMITH VM. NEWER ANTOCHOLINERGIC DRUGS. Med Clin North Am. 1964 Mar;48:399-409. doi: 10.1016/s0025-7125(16)33472-1. PMID: 14149242.
10: NAKAMURA I, ICHIOKA S, MIYOSHI H, ISHII H, KIDA A, ASAKURA A, OMORI M, MIZUOKA S. [EFFECTS OF ISOPROPAMIDE IODIDE ON GASTRIC DISEASES]. Naika Hokan. 1963 Dec;10:511-3. Japanese. PMID: 14100166.
