Milveterol HCl | GSK159797 | CAS#804518-03-4 | 652990-07-3 | β(2)-adrenoceptor agonist

MedKoo Cat#: 319910 | Name: Milveterol HCl

Description:

WARNING: This product is for research use only, not for human or veterinary use.

Milveterol, also known as GSK159797, is a long-acting β(2)-adrenoceptor agonist and potentially useful for the treatment of chronic obstructive pulmonary disease (COPD).

Chemical Structure

Milveterol HCl

CAS#804518-03-4 (HCl salt)

Theoretical Analysis

MedKoo Cat#: 319910

Name: Milveterol HCl

CAS#: 804518-03-4 (HCl salt)

Chemical Formula: C25H31Cl2N3O4

Exact Mass: 435.2158

Molecular Weight: 508.44

Elemental Analysis: C, 59.06; H, 6.15; Cl, 13.94; N, 8.26; O, 12.59

Price and Availability

This product is currently not in stock but may be available through custom synthesis. To ensure cost efficiency, the minimum order quantity is 1 gram. The estimated lead time is 2 to 4 months, with pricing dependent on the complexity of the synthesis (typically high for intricate chemistries). Quotes for quantities below 1 gram will not be provided. To request a quote, please click the button below. Note: If this product becomes available in stock in the future, pricing will be listed accordingly.

Bulk Inquiry

Related CAS #

No Data

Synonym

GSK159797; GSK-159797; GSK 159797; Milveterol

IUPAC/Chemical Name

N-(2-hydroxy-5-((R)-1-hydroxy-2-((4-(((R)-2-hydroxy-2-phenylethyl)amino)phenethyl)amino)ethyl)phenyl)formamide dihydrochloride

InChi Key

CAIJJZHXOQYXRP-LXTBHBSOSA-N

InChi Code

InChI=1S/C25H29N3O4.2ClH/c29-17-28-22-14-20(8-11-23(22)30)24(31)15-26-13-12-18-6-9-21(10-7-18)27-16-25(32)19-4-2-1-3-5-19;;/h1-11,14,17,24-27,30-32H,12-13,15-16H2,(H,28,29);2*1H/t24-,25-;;/m0../s1

SMILES Code

O=CNC1=CC([C@@H](O)CNCCC2=CC=C(NC[C@H](O)C3=CC=CC=C3)C=C2)=CC=C1O.[H]Cl.[H]Cl

Appearance

Solid powder

Purity

>98% (or refer to the Certificate of Analysis)

Shipping Condition

Shipped under ambient temperature as non-hazardous chemical. This product is stable enough for a few weeks during ordinary shipping and time spent in Customs.

Storage Condition

Dry, dark and at 0 - 4 C for short term (days to weeks) or -20 C for long term (months to years).

Solubility

Soluble in DMSO, not in water

Shelf Life

>2 years if stored properly

Drug Formulation

This drug may be formulated in DMSO

Stock Solution Storage

0 - 4 C for short term (days to weeks), or -20 C for long term (months).

HS Tariff Code

2934.99.9001

More Info

Related CAS# 804518-03-4 ( Milveterol HCl salt); 652990-07-3 ( Milveterol free base).

Instruction

View handling instruction

Preparing Stock Solutions

The following data is based on the product molecular weight 508.44 Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which will affect the solvent volumes required to prepare stock solutions.

Concentration / Solvent Volume / Mass	1 mg	5 mg	10 mg
1 mM	1.15 mL	5.76 mL	11.51 mL
5 mM	0.23 mL	1.15 mL	2.3 mL
10 mM	0.12 mL	0.58 mL	1.15 mL
50 mM	0.02 mL	0.12 mL	0.23 mL

1: Montuschi P, Ciabattoni G. Bronchodilating drugs for chronic obstructive pulmonary disease: current status and future trends. J Med Chem. 2015 May 28;58(10):4131-64. doi: 10.1021/jm5013227. Epub 2015 Feb 9. PubMed PMID: 25587755. 2: Jacobsen JR, Aggen JB, Church TJ, Klein U, Pfeiffer JW, Pulido-Rios TM, Thomas GR, Yu C, Moran EJ. Multivalent design of long-acting β(2)-adrenoceptor agonists incorporating biarylamines. Bioorg Med Chem Lett. 2014 Jun 15;24(12):2625-30. doi: 10.1016/j.bmcl.2014.04.069. Epub 2014 Apr 26. PubMed PMID: 24813741. 3: Fuso L, Mores N, Valente S, Malerba M, Montuschi P. Long-acting beta-agonists and their association with inhaled corticosteroids in COPD. Curr Med Chem. 2013;20(12):1477-95. Review. PubMed PMID: 23409722. 4: Jacobsen JR, Choi SK, Combs J, Fournier EJ, Klein U, Pfeiffer JW, Thomas GR, Yu C, Moran EJ. A multivalent approach to the discovery of long-acting β(2)-adrenoceptor agonists for the treatment of asthma and COPD. Bioorg Med Chem Lett. 2012 Jan 15;22(2):1213-8. doi: 10.1016/j.bmcl.2011.11.072. Epub 2011 Nov 25. PubMed PMID: 22178551. 5: Cazzola M, Segreti A, Matera MG. Novel bronchodilators in asthma. Curr Opin Pulm Med. 2010 Jan;16(1):6-12. doi: 10.1097/MCP.0b013e32833303d2. Review. PubMed PMID: 19816179.