Miloxacin | CAS# 37065-29-5 | Antibiotic

MedKoo Cat#: 571305 | Name: Miloxacin

Description:

WARNING: This product is for research use only, not for human or veterinary use.

Miloxacin is an antibiotic active against gram-negative bacteria. It also exhibits chemotherapeutic properties comparable to those of oxolinic acid and nalidixic acid.

Chemical Structure

Miloxacin

CAS#37065-29-5

Theoretical Analysis

MedKoo Cat#: 571305

Name: Miloxacin

CAS#: 37065-29-5

Chemical Formula: C12H9NO6

Exact Mass: 263.0430

Molecular Weight: 263.21

Elemental Analysis: C, 54.76; H, 3.45; N, 5.32; O, 36.47

Price and Availability

This product is currently not in stock but may be available through custom synthesis. To ensure cost efficiency, the minimum order quantity is 1 gram. The estimated lead time is 2 to 4 months, with pricing dependent on the complexity of the synthesis (typically high for intricate chemistries). Quotes for quantities below 1 gram will not be provided. To request a quote, please click the button below. Note: If this product becomes available in stock in the future, pricing will be listed accordingly.

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Related CAS #

No Data

Synonym

Miloxacin; AB 206; AB-206; AB206

IUPAC/Chemical Name

1,3-Dioxolo(4,5-g)quinoline-7-carboxylic acid, 5,8-dihydro-5-methoxy-8-oxo-

InChi Key

ABQYZRZVRIPTPI-UHFFFAOYSA-N

InChi Code

InChI=1S/C12H9NO6/c1-17-13-4-7(12(15)16)11(14)6-2-9-10(3-8(6)13)19-5-18-9/h2-4H,5H2,1H3,(H,15,16)

SMILES Code

O=C(C1=CN(OC)C2=CC(OCO3)=C3C=C2C1=O)O

Appearance

Solid powder

Purity

>98% (or refer to the Certificate of Analysis)

Shipping Condition

Shipped under ambient temperature as non-hazardous chemical. This product is stable enough for a few weeks during ordinary shipping and time spent in Customs.

Storage Condition

Dry, dark and at 0 - 4 C for short term (days to weeks) or -20 C for long term (months to years).

Solubility

Soluble in DMSO

Shelf Life

>2 years if stored properly

Drug Formulation

This drug may be formulated in DMSO

Stock Solution Storage

0 - 4 C for short term (days to weeks), or -20 C for long term (months).

HS Tariff Code

2934.99.9001

More Info

Instruction

View handling instruction

Preparing Stock Solutions

The following data is based on the product molecular weight 263.21 Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which will affect the solvent volumes required to prepare stock solutions.

Concentration / Solvent Volume / Mass	1 mg	5 mg	10 mg
1 mM	1.15 mL	5.76 mL	11.51 mL
5 mM	0.23 mL	1.15 mL	2.3 mL
10 mM	0.12 mL	0.58 mL	1.15 mL
50 mM	0.02 mL	0.12 mL	0.23 mL

1: Izawa A, Kisaki Y, Irie K, Eda Y, Nakagome T, Komatsu T. Antibacterial activity of miloxacin. Antimicrob Agents Chemother. 1980 Jul;18(1):37-40. PubMed PMID: 7416749; PubMed Central PMCID: PMC283935. 2: Yoshitake A, Kawahara K, Izawa A, Shono F. [Absorption, distribution, excretion, and metabolism of 14C-miloxacin in female rats (author's transl)]. Radioisotopes. 1980 Aug;29(8):377-81. Japanese. PubMed PMID: 7208993. 3: Izawa A, Yoshitake A, Komatsu T. Absorption and excretion of miloxacin in mice, rats, and dogs. Antimicrob Agents Chemother. 1980 Jul;18(1):41-4. PubMed PMID: 7416750; PubMed Central PMCID: PMC283936. 4: Yoshitake A, Kawahara K, Shono F, Umeda I, Izawa A, Komatsu T. Determination of miloxacin and metabolites in human serum and urine by high-pressure liquid chromatography. Antimicrob Agents Chemother. 1980 Jul;18(1):45-9. PubMed PMID: 7416751; PubMed Central PMCID: PMC283937. 5: Yoshitake A, Kawahara K, Shono F. [Metabolism of 14C-miloxacin in rats--metabolites in urine, bile and feces (author's transl)]. Radioisotopes. 1979 Nov;28(11):687-91. Japanese. PubMed PMID: 531250. 6: Ueno R, Aoki T. High-performance liquid chromatographic method for the rapid and simultaneous determination of sulfamonomethoxine, miloxacin and oxolinic acid in serum and muscle of cultured fish. J Chromatogr B Biomed Appl. 1996 Jun 28;682(1):179-81. PubMed PMID: 8832440. 7: Srinivas NR. Interspecies scaling of excretory amounts using allometry - retrospective analysis with rifapentine, aztreonam, carumonam, pefloxacin, miloxacin, trovafloxacin, doripenem, imipenem, cefozopran, ceftazidime, linezolid for urinary excretion and rifapentine, cabotegravir, and dolutegravir for fecal excretion. Xenobiotica. 2016 Sep;46(9):784-92. doi: 10.3109/00498254.2015.1121554. Epub 2015 Dec 29. PubMed PMID: 26711252. 8: Nakano M, Kanzaki R, Hayakawa M, Adachi M, Kawai M, Imadaka K, Takizuka H, Okayama K, Katsu M, Nose N, Notoya T, Takeda N. [Clinical studies of miloxacin for acute intestinitis (author's transl)]. Kansenshogaku Zasshi. 1981 Nov;55(11):819-25. Japanese. PubMed PMID: 6801153. 9: [Chemotherapy on the biliary tract infections. XIII. Miloxacin, a novel chemotherapeutic agent, its excretion into bile and clinical effect on the biliary tract infections (author's transl)]. Jpn J Antibiot. 1981 Sep;34(9):1335-52. Japanese. PubMed PMID: 7328756. 10: Igari J, Kosakai N, Oguri T. [Antimicrobial susceptibility patterns of clinical isolates of Pseudomonas cepacia (author's transl)]. Jpn J Antibiot. 1979 Oct;32(10):998-1002. Japanese. PubMed PMID: 259663. 11: Okezaki E, Terasaki T, Nakamura M, Nagata O, Kato H, Tsuji A. Structure-tissue distribution relationship based on physiological pharmacokinetics for NY-198, a new antimicrobial agent, and the related pyridonecarboxylic acids. Drug Metab Dispos. 1988 Nov-Dec;16(6):865-74. PubMed PMID: 2907467. 12: Nagate T, Kurashige S, Mitsuhashi S. In vitro and in vivo antibacterial activity of AB206, a new naphthyridine derivative. Antimicrob Agents Chemother. 1980 Feb;17(2):203-8. PubMed PMID: 7387143; PubMed Central PMCID: PMC283759. 13: Ohno I, Ida S. [Refractory respiratory tract infections. 7. Trends in the development of new chemotherapeutic agents for respiratory tract infections. b. Synthetic antibacterial agents]. Nihon Rinsho. 1987 Mar;45(3):577-82. Review. Japanese. PubMed PMID: 3298736. 14: Nagate T, Komatsu T, Izawa A, Ohmura S, Namiki S, Mitsuhashi S. Mode of action of a new nalidixic acid derivative, AB206. Antimicrob Agents Chemother. 1980 May;17(5):763-9. PubMed PMID: 6156644; PubMed Central PMCID: PMC283872. 15: Umeda I, Anzai H, Murano A. [Determination of a new antibacterial agent miloxacin by high performance liquid chromatography and ultraviolet spectrophotometry (author's transl)]. Yakugaku Zasshi. 1979 Jul;99(7):770-4. Japanese. PubMed PMID: 544795.

View History

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