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MedKoo Cat#: 575272 | Name: Milnacipran

Description:

WARNING: This product is for research use only, not for human or veterinary use.

Milnacipran is a serotonin–norepinephrine reuptake inhibitor (SNRI) used in the clinical treatment of fibromyalgia. It is not approved for the clinical treatment of major depressive disorder in the USA.

Chemical Structure

Milnacipran
Milnacipran
CAS#92623-85-3

Theoretical Analysis

MedKoo Cat#: 575272

Name: Milnacipran

CAS#: 92623-85-3

Chemical Formula: C15H22N2O

Exact Mass: 246.1732

Molecular Weight: 246.35

Elemental Analysis: C, 73.13; H, 9.00; N, 11.37; O, 6.49

Price and Availability

This product is currently not in stock but may be available through custom synthesis. To ensure cost efficiency, the minimum order quantity is 1 gram. The estimated lead time is 2 to 4 months, with pricing dependent on the complexity of the synthesis (typically high for intricate chemistries). Quotes for quantities below 1 gram will not be provided. To request a quote, please click the button below. Note: If this product becomes available in stock in the future, pricing will be listed accordingly.
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Related CAS #
101152-94-7 (HCl)
Synonym
(+-)-Milnacipran; Dalcipran; F 2207; F2207; F-2207; Ixel; Midalcipran; Milnace; Milnacipran; Toledomin
IUPAC/Chemical Name
Cyclopropanecarboxamide, 2-(aminomethyl)-N,N-diethyl-1-phenyl-, cis-(+-)-
InChi Key
GJJFMKBJSRMPLA-HIFRSBDPSA-N
InChi Code
InChI=1S/C15H22N2O/c1-3-17(4-2)14(18)15(10-13(15)11-16)12-8-6-5-7-9-12/h5-9,13H,3-4,10-11,16H2,1-2H3/t13-,15+/m1/s1
SMILES Code
CCN(CC)C(=O)[C@@]1(C[C@@H]1CN)c2ccccc2
Appearance
Solid powder
Purity
>98% (or refer to the Certificate of Analysis)
Shipping Condition
Shipped under ambient temperature as non-hazardous chemical. This product is stable enough for a few weeks during ordinary shipping and time spent in Customs.
Storage Condition
Dry, dark and at 0 - 4 C for short term (days to weeks) or -20 C for long term (months to years).
Solubility
Soluble in DMSO
Shelf Life
>3 years if stored properly
Drug Formulation
This drug may be formulated in DMSO
Stock Solution Storage
0 - 4 C for short term (days to weeks), or -20 C for long term (months).
HS Tariff Code
2934.99.9001
More Info

Preparing Stock Solutions

The following data is based on the product molecular weight 246.35 Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which will affect the solvent volumes required to prepare stock solutions.

Recalculate based on batch purity %
Concentration / Solvent Volume / Mass 1 mg 5 mg 10 mg
1 mM 1.15 mL 5.76 mL 11.51 mL
5 mM 0.23 mL 1.15 mL 2.3 mL
10 mM 0.12 mL 0.58 mL 1.15 mL
50 mM 0.02 mL 0.12 mL 0.23 mL
1: Cording M, Derry S, Phillips T, Moore RA, Wiffen PJ. Milnacipran for pain in fibromyalgia in adults. Cochrane Database Syst Rev. 2015 Oct 20;10:CD008244. doi: 10.1002/14651858.CD008244.pub3. Review. PubMed PMID: 26482422. 2: Derry S, Phillips T, Moore RA, Wiffen PJ. Milnacipran for neuropathic pain in adults. Cochrane Database Syst Rev. 2015 Jul 6;7:CD011789. doi: 10.1002/14651858.CD011789. Review. PubMed PMID: 26148202. 3: Bernstein CD, Albrecht KL, Marcus DA. Milnacipran for fibromyalgia: a useful addition to the treatment armamentarium. Expert Opin Pharmacother. 2013 May;14(7):905-16. doi: 10.1517/14656566.2013.779670. Epub 2013 Mar 19. Review. PubMed PMID: 23506481. 4: Derry S, Gill D, Phillips T, Moore RA. Milnacipran for neuropathic pain and fibromyalgia in adults. Cochrane Database Syst Rev. 2012 Mar 14;3:CD008244. doi: 10.1002/14651858.CD008244.pub2. Review. Update in: Cochrane Database Syst Rev. 2015;10:CD008244. PubMed PMID: 22419330; PubMed Central PMCID: PMC4164830. 5: Häuser W, Petzke F, Üçeyler N, Sommer C. Comparative efficacy and acceptability of amitriptyline, duloxetine and milnacipran in fibromyalgia syndrome: a systematic review with meta-analysis. Rheumatology (Oxford). 2011 Mar;50(3):532-43. doi: 10.1093/rheumatology/keq354. Epub 2010 Nov 14. Review. PubMed PMID: 21078630.