MedKoo Cat#: 319881 | Name: Adipiplon

Description:

WARNING: This product is for research use only, not for human or veterinary use.

Adipiplon, also known as NG2-73 or NG273, is a new, selective gamma-amino butyric acid (GABA) partial agonist under development for the treatment of insomnia, the most common type of sleep disorder. Phase II development initial clinical results suggested that NG2-73 has the capacity to reduce sleep latency as well as increase total sleep time and sleep efficiency in insomnia patients.

Chemical Structure

Adipiplon
CAS#840486-93-3

Theoretical Analysis

MedKoo Cat#: 319881

Name: Adipiplon

CAS#: 840486-93-3

Chemical Formula: C18H18FN7

Exact Mass: 351.1608

Molecular Weight: 351.39

Elemental Analysis: C, 61.53; H, 5.16; F, 5.41; N, 27.90

Price and Availability

This product is currently not in stock but may be available through custom synthesis. To ensure cost efficiency, the minimum order quantity is 1 gram. The estimated lead time is 2 to 4 months, with pricing dependent on the complexity of the synthesis (typically high for intricate chemistries). Quotes for quantities below 1 gram will not be provided. To request a quote, please click the button below. Note: If this product becomes available in stock in the future, pricing will be listed accordingly.
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Related CAS #
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Synonym
NG2-73; NG 2-73; NG-2-73; NG273; NG 273; NG-273; Adipiplon
IUPAC/Chemical Name
7-((2-(3-fluoropyridin-2-yl)-1H-imidazol-1-yl)methyl)-2-methyl-8-propyl-[1,2,4]triazolo[1,5-c]pyrimidine
InChi Key
UAMAIHOEGLEXSV-UHFFFAOYSA-N
InChi Code
InChI=1S/C18H18FN7/c1-3-5-13-15(22-11-26-17(13)23-12(2)24-26)10-25-9-8-21-18(25)16-14(19)6-4-7-20-16/h4,6-9,11H,3,5,10H2,1-2H3
SMILES Code
CCCC1=C(CN2C=CN=C2C3=NC=CC=C3F)N=CN4C1=NC(C)=N4
Appearance
Solid powder
Purity
>98% (or refer to the Certificate of Analysis)
Shipping Condition
Shipped under ambient temperature as non-hazardous chemical. This product is stable enough for a few weeks during ordinary shipping and time spent in Customs.
Storage Condition
Dry, dark and at 0 - 4 C for short term (days to weeks) or -20 C for long term (months to years).
Solubility
Soluble in DMSO, not in water
Shelf Life
>2 years if stored properly
Drug Formulation
This drug may be formulated in DMSO
Stock Solution Storage
0 - 4 C for short term (days to weeks), or -20 C for long term (months).
HS Tariff Code
2934.99.9001
More Info

Preparing Stock Solutions

The following data is based on the product molecular weight 351.39 Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which will affect the solvent volumes required to prepare stock solutions.

Recalculate based on batch purity %
Concentration / Solvent Volume / Mass 1 mg 5 mg 10 mg
1 mM 1.15 mL 5.76 mL 11.51 mL
5 mM 0.23 mL 1.15 mL 2.3 mL
10 mM 0.12 mL 0.58 mL 1.15 mL
50 mM 0.02 mL 0.12 mL 0.23 mL
1: Chen G, Li Y, Xie X, Chen J, Wu T, Li X, Wang H, Zhou Y, Du Z. [Establishment of a new human glioma cell line and analysis of its biological characteristics]. Zhonghua Zhong Liu Za Zhi. 2015 Feb;37(2):84-90. Chinese. PubMed PMID: 25975682. 2: Vinkers CH, Olivier B, Hanania T, Min W, Schreiber R, Hopkins SC, Campbell U, Paterson N. Discriminative stimulus properties of GABAA receptor positive allosteric modulators TPA023, ocinaplon and NG2-73 in rats trained to discriminate chlordiazepoxide or zolpidem. Eur J Pharmacol. 2011 Oct 1;668(1-2):190-3. doi: 10.1016/j.ejphar.2011.06.054. Epub 2011 Jul 8. PubMed PMID: 21762686.