Synonym
Floctafenic acid; Floctafenicacid
IUPAC/Chemical Name
Benzoic acid, 2-((8-(trifluoromethyl)-4-quinolinyl)amino)-
InChi Key
RGUIKQRAZCQMBM-UHFFFAOYSA-N
InChi Code
InChI=1S/C17H11F3N2O2/c18-17(19,20)12-6-3-5-10-14(8-9-21-15(10)12)22-13-7-2-1-4-11(13)16(23)24/h1-9H,(H,21,22)(H,23,24)
SMILES Code
OC(=O)c1ccccc1Nc2ccnc3c(cccc23)C(F)(F)F
Purity
>98% (or refer to the Certificate of Analysis)
Shipping Condition
Shipped under ambient temperature as non-hazardous chemical. This product is stable enough for a few weeks during ordinary shipping and time spent in Customs.
Storage Condition
Dry, dark and at 0 - 4 C for short term (days to weeks) or -20 C for long term (months to years).
Solubility
Soluble in DMSO
Shelf Life
>2 years if stored properly
Drug Formulation
This drug may be formulated in DMSO
Stock Solution Storage
0 - 4 C for short term (days to weeks), or -20 C for long term (months).
HS Tariff Code
2934.99.9001
Preparing Stock Solutions
The following data is based on the
product
molecular weight
332.28
Batch specific molecular weights may vary
from batch to batch
due to the degree of hydration, which will
affect the solvent
volumes required to prepare stock solutions.
| Concentration / Solvent Volume / Mass |
1 mg |
5 mg |
10 mg |
| 1 mM |
1.15 mL |
5.76 mL |
11.51 mL |
| 5 mM |
0.23 mL |
1.15 mL |
2.3 mL |
| 10 mM |
0.12 mL |
0.58 mL |
1.15 mL |
| 50 mM |
0.02 mL |
0.12 mL |
0.23 mL |
1: Walash MI, Belal F, El-Enany N, Eid M, El-Shaheny RN. Simultaneous determination of floctafenine and its hydrolytic degradation product floctafenic acid using micellar liquid chromatography with applications to tablets and human plasma. J AOAC Int. 2013 Nov-Dec;96(6):1315-24. doi: 10.5740/jaoacint.11-255. PMID: 24645510.
2: Albengres E, Urien S, Riant P, Marcel GA, Tillement JP. Binding of two anthranilic acid derivatives to human albumin, erythrocytes, and lipoproteins: evidence for glafenic acid high affinity binding. Mol Pharmacol. 1987 Mar;31(3):294-300. PMID: 2882410.
3: Maenthaisong R, Tacconelli S, Sritara P, Del Boccio P, Di Francesco L, Sacchetta P, Archararit N, Aryurachai K, Patrignani P, Suthisisang C. Clinical pharmacology of cyclooxygenase inhibition and pharmacodynamic interaction with aspirin by floctafenine in Thai healthy subjects. Int J Immunopathol Pharmacol. 2013 Apr-Jun;26(2):403-17. doi: 10.1177/039463201302600213. PMID: 23755755.
4: Tracqui A, Kintz P, Mangin P, Lugnier AA, Chaumont AJ. Simultaneous determination of floctafenine and its main metabolites, floctafenic and hydroxyfloctafenic acid, using high-performance liquid chromatography with gradient elution. J Chromatogr. 1988 Nov 18;432:412-4. doi: 10.1016/s0378-4347(00)80675-1. PMID: 2906064.
5: Abdel-Hay MH, Gharaibeh AM. High-performance liquid chromatographic determination of floctafenine and its major metabolite, floctafenic acid in plasma. J Clin Pharm Ther. 1992 Feb;17(1):31-5. doi: 10.1111/j.1365-2710.1992.tb01261.x. PMID: 1347771.
6: Pottier J, Busigny M, Raynaud JP. Pharmacokinetic study of a peripheral analgesic, floctafenin, in man, mouse, rat, and dog. Drug Metab Dispos. 1975 May-Jun;3(3):133-47. PMID: 238812.
7: Lynn RK, Holm R, Swanson BN, Smith R, Gerber N. The metabolism of floctafenin in man and rodents. J Clin Pharmacol. 1979 Jan;19(1):20-30. doi: 10.1002/j.1552-4604.1979.tb01613.x. PMID: 33200.
8: Nicot G, Lachatre G, Terrier G, Gonnet C, Rocca JL, Desroches R, Lansade A. Simultaneous plasma determination of floctafenin and its major metabolites by high-performance liquid chromatography: preliminary observations in children. Ther Drug Monit. 1989;11(1):67-72. doi: 10.1097/00007691-198901000-00014. PMID: 2563179.
