Tecarfarin, also known as ATI-5923, is a potent and orally active vitamin K epoxide reductase inhibitor with antithrombotic activity. Like warfarin, tecarfarin attenuates venous and arterial thrombus formation in animal models by reducing the levels of the vitamin K-dependent coagulation factors. ecarfarin, via a vitamin K-dependent mechanism, causes changes in key parameters of haemostasis in beagle dogs that are consistent with effective anticoagulation. Compared to warfarin it has a decreased potential to interact metabolically with drugs that inhibit CYP450 enzymes and, therefore, may offer an improved safety profile for patients.
MedKoo Cat#: 319844
Name: Tecarfarin
CAS#: 867257-26-9
Chemical Formula: C21H14F6O5
Exact Mass: 460.0745
Molecular Weight: 460.33
Elemental Analysis: C, 54.79; H, 3.07; F, 24.76; O, 17.38
The following data is based on the product molecular weight 460.33 Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which will affect the solvent volumes required to prepare stock solutions.
| Concentration / Solvent Volume / Mass | 1 mg | 5 mg | 10 mg |
|---|---|---|---|
| 1 mM | 1.15 mL | 5.76 mL | 11.51 mL |
| 5 mM | 0.23 mL | 1.15 mL | 2.3 mL |
| 10 mM | 0.12 mL | 0.58 mL | 1.15 mL |
| 50 mM | 0.02 mL | 0.12 mL | 0.23 mL |
