Synonym
Cefotaxime Sodium; Cefotaxime sodium salt; Cefotaxim sodium salt; Cefotax; CHEBI:3498; Merck Brand of Cefotaxime Sodium; Pisa Brand of Cefotaxime Sodium; Primafen; Ru 24756; Ru-24756; Ru24756; Sodium, Cefotaxime; Taporin; Viken Brand of Cefotaxime Sodium;
IUPAC/Chemical Name
sodium;(6R,7R)-3-(acetyloxymethyl)-7-[[(2Z)-2-(2-amino-1,3-thiazol-4-yl)-2-methoxyiminoacetyl]amino]-8-oxo-5-thia-1-azabicyclo[4.2.0]oct-2-ene-2-carboxylate
InChi Key
AZZMGZXNTDTSME-JUZDKLSSSA-M
InChi Code
InChI=1S/C16H17N5O7S2.Na/c1-6(22)28-3-7-4-29-14-10(13(24)21(14)11(7)15(25)26)19-12(23)9(20-27-2)8-5-30-16(17)18-8;/h5,10,14H,3-4H2,1-2H3,(H2,17,18)(H,19,23)(H,25,26);/q;+1/p-1/b20-9-;/t10-,14-;/m1./s1
SMILES Code
CC(=O)OCC1=C(N2[C@@H]([C@@H](C2=O)NC(=O)/C(=N\OC)/C3=CSC(=N3)N)SC1)C(=O)[O-].[Na+]
Purity
>95% (or refer to the Certificate of Analysis)
Shipping Condition
Shipped under ambient temperature as non-hazardous chemical. This product is stable enough for a few weeks during ordinary shipping and time spent in Customs.
Storage Condition
Dry, dark and at 0 - 4 C for short term (days to weeks) or -20 C for long term (months to years).
Solubility
Soluble in DMSO, not in water
Shelf Life
>2 years if stored properly
Drug Formulation
This drug may be formulated in DMSO
Stock Solution Storage
0 - 4 C for short term (days to weeks), or -20 C for long term (months).
HS Tariff Code
2934.99.9001
Preparing Stock Solutions
The following data is based on the
product
molecular weight
477.45
Batch specific molecular weights may vary
from batch to batch
due to the degree of hydration, which will
affect the solvent
volumes required to prepare stock solutions.
| Concentration / Solvent Volume / Mass |
1 mg |
5 mg |
10 mg |
| 1 mM |
1.15 mL |
5.76 mL |
11.51 mL |
| 5 mM |
0.23 mL |
1.15 mL |
2.3 mL |
| 10 mM |
0.12 mL |
0.58 mL |
1.15 mL |
| 50 mM |
0.02 mL |
0.12 mL |
0.23 mL |
1: Türkeş C, Söyüt H, Beydemir Ş. Human serum paraoxonase-1 (hPON1): in vitro
inhibition effects of moxifloxacin hydrochloride, levofloxacin hemihidrate,
cefepime hydrochloride, cefotaxime sodium and ceftizoxime sodium. J Enzyme Inhib
Med Chem. 2015;30(4):622-8. doi: 10.3109/14756366.2014.959511. Epub 2014 Dec 18.
PubMed PMID: 25519764.
2: Sharma R, Choudhary S, Kishore N. Insights into the binding of the drugs
diclofenac sodium and cefotaxime sodium to serum albumin: calorimetry and
spectroscopy. Eur J Pharm Sci. 2012 Aug 15;46(5):435-45. doi:
10.1016/j.ejps.2012.03.007. Epub 2012 Mar 29. PubMed PMID: 22483968.
3: Chen D, Wang H, Zhang Z, Ci L, Zhang X. Chemiluminescence determination of
cefotaxime sodium with flow-injection analysis of cerium (IV)-rhodamine 6G system
and its application to the binding study of cefotaxime sodium to protein with
on-line microdialysis sampling. Spectrochim Acta A Mol Biomol Spectrosc. 2011
Jan;78(1):553-7. doi: 10.1016/j.saa.2010.10.014. Epub 2010 Nov 3. PubMed PMID:
21050805.
4: Lalitha N, Pai PS. Development and validation of RP-HPLC method for estimation
of Cefotaxime sodium in marketed formulations. J Basic Clin Pharm. 2009
Dec;1(1):26-8. Epub 2010 Feb 15. PubMed PMID: 25206249; PubMed Central PMCID:
PMC4158899.
5: Gupta VD. Stability of cefotaxime sodium after reconstitution in 0.9% sodium
chloride injection and storage in polypropylene syringes for pediatric use. Int J
Pharm Compd. 2002 May-Jun;6(3):234-6. PubMed PMID: 23979191.
6: Zajac M, Musiał W, Pawłowski L. Stability of cefotaxime sodium in solid state.
Pharmazie. 2000 Dec;55(12):917-8. PubMed PMID: 11189867.
7: Szof C, Walker PC. Incompatibility of cefotaxime sodium and vancomycin sulfate
during Y-site administration. Am J Hosp Pharm. 1993 Oct;50(10):2054, 2057. PubMed
PMID: 8238042.
8: Rivers TE, McBride HA, Trang JM. Stability of cefotaxime sodium and
metronidazole in an i.v. admixture at 8 degrees C. Am J Hosp Pharm. 1991
Dec;48(12):2638-40. PubMed PMID: 1814208.
9: Jones RN. Review of cefotaxime sodium for surgical prophylaxis. A model for
the evolution toward single-dose or short-course cost-effective regimens. Diagn
Microbiol Infect Dis. 1990 Jul-Aug;13(4):317-27. Review. Erratum in: Diagn
Microbiol Infect Dis 1991 Mar-Apr;14(2):190. PubMed PMID: 2076593.
10: Ker CG, Hou MF, Chen JS, Lee KT, Sheen PC, Akbary MA. A comparative study of
cefotaxime sodium versus a combination of cefapirin and gentamicin in the
prophylactic treatment of patients undergoing cholecystectomy. Methods Find Exp
Clin Pharmacol. 1989 Nov;11(11):711-5. PubMed PMID: 2695726.
11: Current status of cefotaxime sodium: a new cephalosporin. A symposium.
Phoenix, Arizona, January 12 and 13, 1981. Rev Infect Dis. 1982 Sep-Oct;4
Suppl:S281-488. PubMed PMID: 6294777.
12: Martin S. Claforan (cefotaxime sodium). Lamp. 1982 May-Jun;39(3):47-8. PubMed
PMID: 6287132.
13: Cefotaxime sodium (Claforan). Med Lett Drugs Ther. 1981 Jul 10;23(14):61-2.
PubMed PMID: 6264279.
14: Zahid MA, Bakhsh R, Dar FS, Akhter N, Malik ZI. Comparison of single dose and
three dose antibiotic prophylaxis with cefotaxime sodium in cholecystectomy. J
Ayub Med Coll Abbottabad. 2003 Jan-Mar;15(1):38-40. PubMed PMID: 12870316.
15: Morelli B. Derivative spectrophotometry in the analysis of mixtures of
cefotaxime sodium and cefadroxil monohydrate. J Pharm Biomed Anal. 2003 Jun
1;32(2):257-67. PubMed PMID: 12763535.
16: Crucq AS, Tilquin B. Method to identify products induced by
radiosterilization. A study of cefotaxime sodium. J Pharm Belg. 1996
Nov-Dec;51(6):285-8. PubMed PMID: 9014401.
17: Belliveau PP, Nightingale CH, Quintiliani R. Stability of cefotaxime sodium
and metronidazole in 0.9% sodium chloride injection or in ready-to-use
metronidazole bags. Am J Health Syst Pharm. 1995 Jul 15;52(14):1561-3. PubMed
PMID: 7552904.
18: Bergquist SO, Eriksson I, Eriksson S, Lönnbro N, Runehagen A, Styrud J,
Ahlquist G. Retrospective analysis of the efficacy of cefotaxime sodium dosed
twice daily. The Swedish experience. Diagn Microbiol Infect Dis. 1995
May-Jun;22(1-2):163-6. PubMed PMID: 7587033.
19: Wetterich U, Mutschler E. Quality of cefotaxime sodium preparations.
Arzneimittelforschung. 1995 Jan;45(1):74-80. PubMed PMID: 7893275.
20: Motohiro T, Haruta T. [Reevaluation of current antimicrobials. Cefotaxime
sodium]. Jpn J Antibiot. 1994 Aug;47(8):967-74. Japanese. PubMed PMID: 7933540.
