PNX-14 | CAS#unknown | Neuropeptide

MedKoo Cat#: 464546 | Name: PNX-14

Description:

WARNING: This product is for research use only, not for human or veterinary use.

PNX-14 is a novel neuropeptide, protecting human brain vascular endothelial cells against oxygen-glucose deprivation/reoxygenation (OGD/R)-induced inflammation and permeability, significantly ameliorating HFD-induced obesity and fatty liver, regulating pituitary gonadotropin secretion by modulating expression of the GnRH receptor

Chemical Structure

PNX-14

CAS#unknown

Theoretical Analysis

MedKoo Cat#: 464546

Name: PNX-14

CAS#: unknown

Chemical Formula: C75H110N18O20

Exact Mass: 1582.8144

Molecular Weight: 1583.81

Elemental Analysis: C, 56.88; H, 7.00; N, 15.92; O, 20.20

Price and Availability

This product is currently not in stock but may be available through custom synthesis. To ensure cost efficiency, the minimum order quantity is 1 gram. The estimated lead time is 2 to 4 months, with pricing dependent on the complexity of the synthesis (typically high for intricate chemistries). Quotes for quantities below 1 gram will not be provided. To request a quote, please click the button below. Note: If this product becomes available in stock in the future, pricing will be listed accordingly.

Bulk Inquiry

Related CAS #

No Data

Synonym

PNX-14; PNX14; PNX 14; Phoenixin-14; Phoenixin 14; DVQPPGLKVWSDPF-NH2; DVQPPGLKVWSDPFNH2; DVQPPGLKVWSDPF NH2;

IUPAC/Chemical Name

(S)-3-((S)-2-((S)-2-((S)-2-((S)-2-((S)-2-(2-((S)-1-(L-aspartyl-L-valyl-L-glutaminyl-L-prolyl)pyrrolidine-2-carboxamido)acetamido)-4-methylpentanamido)-6-aminohexanamido)-3-methylbutanamido)-3-(1H-indol-3-yl)propanamido)-3-hydroxypropanamido)-4-((S)-2-(((S)-1-amino-1-oxo-3-phenylpropan-2-yl)carbamoyl)pyrrolidin-1-yl)-4-oxobutanoic acid

InChi Key

WTUJETLCZZFKER-NLPGSOORSA-N

InChi Code

InChI=1S/C75H110N18O20/c1-39(2)31-50(82-58(96)37-81-69(107)54-22-14-29-92(54)75(113)56-24-16-30-93(56)73(111)48(25-26-57(78)95)84-71(109)61(40(3)4)89-64(102)45(77)34-59(97)98)66(104)83-47(21-12-13-27-76)65(103)90-62(41(5)6)72(110)86-51(33-43-36-80-46-20-11-10-19-44(43)46)67(105)88-53(38-94)68(106)87-52(35-60(99)100)74(112)91-28-15-23-55(91)70(108)85-49(63(79)101)32-42-17-8-7-9-18-42/h7-11,17-20,36,39-41,45,47-56,61-62,80,94H,12-16,21-35,37-38,76-77H2,1-6H3,(H2,78,95)(H2,79,101)(H,81,107)(H,82,96)(H,83,104)(H,84,109)(H,85,108)(H,86,110)(H,87,106)(H,88,105)(H,89,102)(H,90,103)(H,97,98)(H,99,100)/t45-,47-,48-,49-,50-,51-,52-,53-,54-,55-,56-,61-,62-/m0/s1

SMILES Code

O=C(N[C@@H](C(C)C)C(N[C@@H](CCC(N)=O)C(N1[C@@H](CCC1)C(N2[C@@H](CCC2)C(NCC(N[C@@H](CC(C)C)C(N[C@@H](CCCCN)C(N[C@@H](C(C)C)C(N[C@@H](CC3=CNC4=CC=CC=C34)C(N[C@@H](CO)C(N[C@@H](CC(O)=O)C(N5[C@@H](CCC5)C(N[C@@H](CC6=CC=CC=C6)C(N)=O)=O)=O)=O)=O)=O)=O)=O)=O)=O)=O)=O)=O)[C@H](CC(O)=O)N

Appearance

Solid powder

Purity

>98% (or refer to the Certificate of Analysis)

Shipping Condition

Shipped under ambient temperature as non-hazardous chemical. This product is stable enough for a few weeks during ordinary shipping and time spent in Customs.

Storage Condition

Dry, dark and at 0 - 4 C for short term (days to weeks) or -20 C for long term (months to years).

Solubility

To be determined

Shelf Life

>2 years if stored properly

Drug Formulation

To be determined

Stock Solution Storage

0 - 4 C for short term (days to weeks), or -20 C for long term (months).

HS Tariff Code

2934.99.9001

More Info

Instruction

View handling instruction

Preparing Stock Solutions

The following data is based on the product molecular weight 1,583.81 Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which will affect the solvent volumes required to prepare stock solutions.

Concentration / Solvent Volume / Mass	1 mg	5 mg	10 mg
1 mM	1.15 mL	5.76 mL	11.51 mL
5 mM	0.23 mL	1.15 mL	2.3 mL
10 mM	0.12 mL	0.58 mL	1.15 mL
50 mM	0.02 mL	0.12 mL	0.23 mL

1: Mukherjee K, Unniappan S. Mouse Gastric Mucosal Endocrine Cells are Sources and Sites of Action of Phoenixin-20. Peptides. 2021 Apr 13:170551. doi: 10.1016/j.peptides.2021.170551. Epub ahead of print. PMID: 33862165. 2: Kalamon N, Błaszczyk K, Szlaga A, Billert M, Skrzypski M, Pawlicki P, Górowska-Wójtowicz E, Kotula-Balak M, Błasiak A, Rak A. Levels of the neuropeptide phoenixin-14 and its receptor GRP173 in the hypothalamus, ovary and periovarian adipose tissue in rat model of polycystic ovary syndrome. Biochem Biophys Res Commun. 2020 Aug 6;528(4):628-635. doi: 10.1016/j.bbrc.2020.05.101. Epub 2020 Jun 3. PMID: 32505354. 3: Ma H, Su D, Wang Q, Chong Z, Zhu Q, He W, Wang W. Phoenixin 14 inhibits ischemia/reperfusion-induced cytotoxicity in microglia. Arch Biochem Biophys. 2020 Aug 15;689:108411. doi: 10.1016/j.abb.2020.108411. Epub 2020 May 23. PMID: 32450066. 4: Wang J, Zheng B, Yang S, Tang X, Wang J, Wei D. The protective effects of phoenixin-14 against lipopolysaccharide-induced inflammation and inflammasome activation in astrocytes. Inflamm Res. 2020 Aug;69(8):779-787. doi: 10.1007/s00011-020-01355-9. Epub 2020 May 20. PMID: 32435966. 5: Wang M, Chen HP, Zhai Y, Jiang DN, Liu JY, Tian CX, Wu TL, Zhu CH, Deng SP, Li GL. Phoenixin: Expression at different ovarian development stages and effects on genes ralated to reproduction in spotted scat, Scatophagus argus. Comp Biochem Physiol B Biochem Mol Biol. 2019 Feb;228:17-25. doi: 10.1016/j.cbpb.2018.10.005. Epub 2018 Nov 10. PMID: 30423433. 6: Wang M, Deng SP, Chen HP, Jiang DN, Tian CX, Yang W, Wu TL, Zhu CH, Zhang Y, Li GL. Phoenixin participated in regulation of food intake and growth in spotted scat, Scatophagus argus. Comp Biochem Physiol B Biochem Mol Biol. 2018 Dec;226:36-44. doi: 10.1016/j.cbpb.2018.07.007. Epub 2018 Aug 13. PMID: 30114526. 7: Lyu RM, Cowan A, Zhang Y, Chen YH, Dun SL, Chang JK, Dun NJ, Luo JJ. Phoenixin: a novel brain-gut-skin peptide with multiple bioactivity. Acta Pharmacol Sin. 2018 May;39(5):770-773. doi: 10.1038/aps.2017.195. Epub 2018 Mar 15. PMID: 29542680; PMCID: PMC5943905. 8: Yuan T, Sun Z, Zhao W, Wang T, Zhang J, Niu D. Phoenixin: A Newly Discovered Peptide with Multi-Functions. Protein Pept Lett. 2017;24(6):472-475. doi: 10.2174/0929866524666170207154417. PMID: 28176660. 9: Jiang JH, He Z, Peng YL, Jin WD, Wang Z, Mu LY, Chang M, Wang R. Phoenixin-14 enhances memory and mitigates memory impairment induced by Aβ1-42 and scopolamine in mice. Brain Res. 2015 Dec 10;1629:298-308. doi: 10.1016/j.brainres.2015.10.030. Epub 2015 Oct 23. PMID: 26505917. 10: Cowan A, Lyu RM, Chen YH, Dun SL, Chang JK, Dun NJ. Phoenixin: A candidate pruritogen in the mouse. Neuroscience. 2015 Dec 3;310:541-8. doi: 10.1016/j.neuroscience.2015.09.055. Epub 2015 Sep 28. PMID: 26415767; PMCID: PMC4633352. 11: Jiang JH, He Z, Peng YL, Jin WD, Mu J, Xue HX, Wang Z, Chang M, Wang R. Effects of Phoenixin-14 on anxiolytic-like behavior in mice. Behav Brain Res. 2015 Jun 1;286:39-48. doi: 10.1016/j.bbr.2015.02.011. Epub 2015 Feb 14. PMID: 25687846.