MedKoo Cat#: 130104 | Name: PNU-141803

Description:

WARNING: This product is for research use only, not for human or veterinary use.

PNU-141803 is an inhibitor of both the stromelysin catalytic domain and thiadiazole. It is an MMP-3 inhibitor.

Chemical Structure

PNU-141803
PNU-141803
CAS#N/A

Theoretical Analysis

MedKoo Cat#: 130104

Name: PNU-141803

CAS#: N/A

Chemical Formula: C19H18N4O3S2

Exact Mass: 414.0820

Molecular Weight: 414.50

Elemental Analysis: C, 55.06; H, 4.38; N, 13.52; O, 11.58; S, 15.47

Price and Availability

This product is currently not in stock but may be available through custom synthesis. To ensure cost efficiency, the minimum order quantity is 1 gram. The estimated lead time is 2 to 4 months, with pricing dependent on the complexity of the synthesis (typically high for intricate chemistries). Quotes for quantities below 1 gram will not be provided. To request a quote, please click the button below. Note: If this product becomes available in stock in the future, pricing will be listed accordingly.
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Related CAS #
No Data
Synonym
PNU-141803; PNU141803; PNU 141803
IUPAC/Chemical Name
Benzyl (R)-(3-oxo-1-phenyl-3-((5-thioxo-4,5-dihydro-1,3,4-thiadiazol-2-yl)amino)propyl)carbamate
InChi Key
AWAKNMKLVLWIIQ-OAHLLOKOSA-N
InChi Code
InChI=1S/C19H18N4O3S2/c24-16(21-17-22-23-19(27)28-17)11-15(14-9-5-2-6-10-14)20-18(25)26-12-13-7-3-1-4-8-13/h1-10,15H,11-12H2,(H,20,25)(H,23,27)(H,21,22,24)/t15-/m1/s1
SMILES Code
O=C(OCC1=CC=CC=C1)N[C@@H](C2=CC=CC=C2)CC(NC(S3)=NNC3=S)=O
Appearance
To be determined
Purity
>98% (or refer to the Certificate of Analysis)
Shipping Condition
Shipped under ambient temperature as non-hazardous chemical. This product is stable enough for a few weeks during ordinary shipping and time spent in Customs.
Storage Condition
Dry, dark and at 0 - 4 C for short term (days to weeks) or -20 C for long term (months to years).
Solubility
To be determined
Shelf Life
>2 years if stored properly
Drug Formulation
To be determined
Stock Solution Storage
0 - 4 C for short term (days to weeks), or -20 C for long term (months).
HS Tariff Code
2934.99.9001
More Info

Preparing Stock Solutions

The following data is based on the product molecular weight 414.50 Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which will affect the solvent volumes required to prepare stock solutions.

Recalculate based on batch purity %
Concentration / Solvent Volume / Mass 1 mg 5 mg 10 mg
1 mM 1.15 mL 5.76 mL 11.51 mL
5 mM 0.23 mL 1.15 mL 2.3 mL
10 mM 0.12 mL 0.58 mL 1.15 mL
50 mM 0.02 mL 0.12 mL 0.23 mL
1. Finzel BC, Baldwin ET, Bryant GL Jr, Hess GF, Wilks JW, Trepod CM, Mott JE, Marshall VP, Petzold GL, Poorman RA, O'Sullivan TJ, Schostarez HJ, Mitchell MA. Structural characterizations of nonpeptidic thiadiazole inhibitors of matrix metalloproteinases reveal the basis for stromelysin selectivity. Protein Sci. 1998 Oct;7(10):2118-26. doi: 10.1002/pro.5560071008. PMID: 9792098; PMCID: PMC2143846.