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MedKoo Cat#: 317376 | Name: Carteolol Hydrochloride
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Description:

WARNING: This product is for research use only, not for human or veterinary use.

Carteolol hydrochloride is a beta-adrenergic antagonist used as an anti-arrhythmia agent, an anti-angina agent, an antihypertensive agent, and an antiglaucoma agent. Carteolol Hydrochloride is a nonselective beta-adrenoceptor blocking agent for beta-1 and beta-2 receptors with no membrane-stabilizing activity but moderate intrinsic sympathomimetic effects.

Chemical Structure

Carteolol Hydrochloride
Carteolol Hydrochloride
CAS#51781-21-6 (HCl)

Theoretical Analysis

MedKoo Cat#: 317376

Name: Carteolol Hydrochloride

CAS#: 51781-21-6 (HCl)

Chemical Formula: C16H25ClN2O3

Exact Mass: 0.0000

Molecular Weight: 328.83

Elemental Analysis: C, 58.44; H, 7.66; Cl, 10.78; N, 8.52; O, 14.60

Price and Availability

Size Price Availability Quantity
50mg USD 350.00 2 Weeks
100mg USD 550.00 2 Weeks
250mg USD 950.00 2 Weeks
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Related CAS #
51781-21-6 (HCl) 51781-06-7 (free base)
Synonym
Carteolol Hydrochloride; Carteolol HCl; Arteoptic; Cartrol; Mikelan; Hydrochloride, Carteolol; Monohydrochloride, Carteolol; OPC 1085; OPC-1085; OPC1085;
IUPAC/Chemical Name
5-[3-(tert-butylamino)-2-hydroxypropoxy]-3,4-dihydro-1H-quinolin-2-one;hydrochloride
InChi Key
FYBXRCFPOTXTJF-UHFFFAOYSA-N
InChi Code
InChI=1S/C16H24N2O3.ClH/c1-16(2,3)17-9-11(19)10-21-14-6-4-5-13-12(14)7-8-15(20)18-13;/h4-6,11,17,19H,7-10H2,1-3H3,(H,18,20);1H
SMILES Code
CC(C)(C)NCC(COC1=CC=CC2=C1CCC(=O)N2)O.Cl
Appearance
Solid powder
Purity
>98% (or refer to the Certificate of Analysis)
Shipping Condition
Shipped under ambient temperature as non-hazardous chemical. This product is stable enough for a few weeks during ordinary shipping and time spent in Customs.
Storage Condition
Dry, dark and at 0 - 4 C for short term (days to weeks) or -20 C for long term (months to years).
Solubility
Soluble in DMSO, not in water
Shelf Life
>2 years if stored properly
Drug Formulation
This drug may be formulated in DMSO
Stock Solution Storage
0 - 4 C for short term (days to weeks), or -20 C for long term (months).
HS Tariff Code
2934.99.9001
More Info

Preparing Stock Solutions

The following data is based on the product molecular weight 328.83 Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which will affect the solvent volumes required to prepare stock solutions.

Recalculate based on batch purity %
Concentration / Solvent Volume / Mass 1 mg 5 mg 10 mg
1 mM 1.15 mL 5.76 mL 11.51 mL
5 mM 0.23 mL 1.15 mL 2.3 mL
10 mM 0.12 mL 0.58 mL 1.15 mL
50 mM 0.02 mL 0.12 mL 0.23 mL
1: Yao Q, Yu X, Zheng T, Liu H, Yang Y, Yi P. Spectroscopic studies on the interaction of carteolol hydrochloride and urea-induced bovine serum albumin. Spectrochim Acta A Mol Biomol Spectrosc. 2013 Sep;113:447-51. doi: 10.1016/j.saa.2013.04.129. Epub 2013 May 16. PubMed PMID: 23747387. 2: Chikama T, Araie M, Nishida T. [Influence on ocular surface and intraocular pressure of switching from preservative-containing to preservative-free carteolol hydrochloride ophthalmic solution]. Nippon Ganka Gakkai Zasshi. 2013 May;117(5):419-26. Japanese. PubMed PMID: 23855234. 3: Ishida S, Mochimaru H, Nagai N, Noda K, Ozawa Y. [Effects of carteolol hydrochloride on experimental choroidal neovascularization]. Nippon Ganka Gakkai Zasshi. 2011 Apr;115(4):355-61. Japanese. PubMed PMID: 21598603. 4: Kawase K, Yamamoto T, Muramatsu T, Ono J, Nakajima T, Matsuhisa A, Sugiura T, Migita M, Ishikawa Y. [Long-acting carteolol hydrochloride 2% ophthalmic solution phase IV study--investigation of the effectiveness, safety and plasma concentration]. Nippon Ganka Gakkai Zasshi. 2010 Nov;114(11):976-82. Japanese. PubMed PMID: 21141077. 5: Kaji Y, Kiuchi T, Oshika T. Carteolol hydrochloride suppresses the generation of reactive oxygen species and rescues cell death after ultraviolet irradiation of cultured lens epithelial cells. Open Ophthalmol J. 2010 Oct 12;4:60-5. doi: 10.2174/1874364101004010060. PubMed PMID: 21283534; PubMed Central PMCID: PMC3031156. 6: Nakamoto K, Yasuda N. Effect of carteolol hydrochloride on 24-hour variation of intraocular pressure in normal-tension glaucoma. Jpn J Ophthalmol. 2010 Mar;54(2):140-3. doi: 10.1007/s10384-009-0780-6. Epub 2010 Apr 18. PubMed PMID: 20401563. 7: Kuwahara K, Oizumi N, Fujisawa S, Tanito M, Ohira A. Carteolol hydrochloride protects human corneal epithelial cells from UVB-induced damage in vitro. Cornea. 2005 Mar;24(2):213-20. PubMed PMID: 15725891. 8: Kawai K, Kuwahara K, Oizumi N, Kitagaki H, Fujisawa S. Effects of carteolol hydrochloride on the in vitro production of LPS-induced proinflammatory cytokines by murine macrophage. J Ocul Pharmacol Ther. 2004 Jun;20(3):237-45. PubMed PMID: 15279728. 9: Isawa S, Murasaki M, Miura S, Yoshioka M, Uchiumi M, Kumagai Y, Aoki S, Hisazumi H, Kudo S. Pharmacokinetic and pharmacodynamic interactions among haloperidol, carteolol hydrochloride and biperiden hydrochloride. Nihon Shinkei Seishin Yakurigaku Zasshi. 1999 Jul;19(3):111-8. PubMed PMID: 10495985. 10: Kober G, Veidt J, Mikludy R, Kaltenbach M. [Heart rate behavior and the ischemic ST-segment under carteolol hydrochloride. Dose-response relationship and duration of effect]. Arzneimittelforschung. 1983;33(2a):313-7. German. PubMed PMID: 6682323. 11: El-Kamel A, Al-Dosari H, Al-Jenoobi F. Environmentally responsive ophthalmic gel formulation of carteolol hydrochloride. Drug Deliv. 2006 Jan-Feb;13(1):55-9. PubMed PMID: 16401594. 12: Stewart WC, Cohen JS, Netland PA, Weiss H, Nussbaum LL. Efficacy of carteolol hydrochloride 1% vs timolol maleate 0.5% in patients with increased intraocular pressure. Nocturnal Investigation of Glaucoma Hemodynamics Trial Study Group. Am J Ophthalmol. 1997 Oct;124(4):498-505. PubMed PMID: 9323940. 13: Kudo S, Umehara K, Abe Y, Furukawa M, Odomi M. Intracerebral penetration of carteolol hydrochloride in rats. Psychopharmacology (Berl). 1997 Jun;131(4):388-93. PubMed PMID: 9226741. 14: Netland PA, Weiss HS, Stewart WC, Cohen JS, Nussbaum LL. Cardiovascular effects of topical carteolol hydrochloride and timolol maleate in patients with ocular hypertension and primary open-angle glaucoma. Night Study Group. Am J Ophthalmol. 1997 Apr;123(4):465-77. PubMed PMID: 9124243. 15: Kikuchi T, Uwahodo Y, Tottori K, Nakai M, Morita S. The attenuating effect of carteolol hydrochloride, a beta-adrenoceptor antagonist, on neuroleptic-induced catalepsy in rats. Psychopharmacology (Berl). 1997 May;131(2):108-14. PubMed PMID: 9201797. 16: van Husen H. [1% carteolol hydrochloride eyedrops: long-term experience in the treatment of chronic open-angle glaucoma]. Klin Monbl Augenheilkd. 1986 Dec;189(6):491-5. German. PubMed PMID: 3550260. 17: Mizuki K, Yamazaki Y. [Effect of carteolol hydrochloride on ocular blood flow dynamics in normal human eyes]. Nippon Ganka Gakkai Zasshi. 2000 Apr;104(4):226-31. Japanese. PubMed PMID: 10793541. 18: Mirza GE, Karaküçük S, Temel E. Comparison of the effects of 0.5% timolol maleate, 2% carteolol hydrochloride, and 0.3% metipranolol on intraocular pressure and perimetry findings and evaluation of their ocular and systemic effects. J Glaucoma. 2000 Feb;9(1):45-50. PubMed PMID: 10708231. 19: Tamagawa M, Numoto T, Tanaka N, Nishino H. Reproduction study of carteolol hydrochloride in mice. Part 2. Peri -and postnatal toxicity. J Toxicol Sci. 1979 Feb;4(1):59-77. PubMed PMID: 480406. 20: Tanaka N, Shingai F, Tamagawa M, Nakatsu I. Reproduction study of carteolol hydrochloride in mice. Part I. Fertility and reproductive performance. J Toxicol Sci. 1979 Feb;4(1):47-58. PubMed PMID: 480405.