Synonym
Carteolol (free base), UNII-8NF31401XG, Carteololum
IUPAC/Chemical Name
2(1H)-Quinolinone, 5-(3-((1,1-dimethylethyl)amino)-2-hydroxypropoxy)-3,4-dihydro-
InChi Key
LWAFSWPYPHEXKX-UHFFFAOYSA-N
InChi Code
InChI=1S/C16H24N2O3/c1-16(2,3)17-9-11(19)10-21-14-6-4-5-13-12(14)7-8-15(20)18-13/h4-6,11,17,19H,7-10H2,1-3H3,(H,18,20)
SMILES Code
O=C1NC2=C(C(OCC(O)CNC(C)(C)C)=CC=C2)CC1
Purity
>98% (or refer to the Certificate of Analysis)
Shipping Condition
Shipped under ambient temperature as non-hazardous chemical. This product is stable enough for a few weeks during ordinary shipping and time spent in Customs.
Storage Condition
Dry, dark and at 0 - 4 C for short term (days to weeks) or -20 C for long term (months to years).
Solubility
Soluble in DMSO
Shelf Life
>3 years if stored properly
Drug Formulation
This drug may be formulated in DMSO
Stock Solution Storage
0 - 4 C for short term (days to weeks), or -20 C for long term (months).
HS Tariff Code
2934.99.9001
Preparing Stock Solutions
The following data is based on the
product
molecular weight
292.38
Batch specific molecular weights may vary
from batch to batch
due to the degree of hydration, which will
affect the solvent
volumes required to prepare stock solutions.
| Concentration / Solvent Volume / Mass |
1 mg |
5 mg |
10 mg |
| 1 mM |
1.15 mL |
5.76 mL |
11.51 mL |
| 5 mM |
0.23 mL |
1.15 mL |
2.3 mL |
| 10 mM |
0.12 mL |
0.58 mL |
1.15 mL |
| 50 mM |
0.02 mL |
0.12 mL |
0.23 mL |
1: Drugs and Lactation Database (LactMed) [Internet]. Bethesda (MD): National Library of Medicine (US); 2006–. Carteolol. 2020 Oct 19. PMID: 30000575.
2: Fuwa M, Shimazaki A, Mieda M, Yamashita N, Akaishi T, Taniguchi T, Kato M. Efficacy and safety of the fixed combinations of tafluprost/timolol and latanoprost/carteolol. Sci Rep. 2019 May 16;9(1):7491. doi: 10.1038/s41598-019-44028-2. PMID: 31097790; PMCID: PMC6522485.
3: Matsuo M, Kuse Y, Takahashi K, Kuwahara K, Tanito M, Kaidzu S, Shimazawa M, Hara H, Ohira A. Carteolol hydrochloride reduces visible light-induced retinal damage in vivo and BSO/glutamate-induced oxidative stress in vitro. J Pharmacol Sci. 2019 Feb;139(2):84-90. doi: 10.1016/j.jphs.2018.11.010. Epub 2018 Dec 6. PMID: 30580970.
4: Henness S, Swainston Harrison T, Keating GM. Ocular carteolol: a review of its use in the management of glaucoma and ocular hypertension. Drugs Aging. 2007;24(6):509-28. doi: 10.2165/00002512-200724060-00007. PMID: 17571916.
5: Nagai N, Yamaoka S, Fukuoka Y, Ishii M, Otake H, Kanai K, Okamoto N, Shimomura Y. Enhancement in Corneal Permeability of Dissolved Carteolol by Its Combination with Magnesium Hydroxide Nanoparticles. Int J Mol Sci. 2018 Jan 17;19(1):282. doi: 10.3390/ijms19010282. PMID: 29342127; PMCID: PMC5796228.
6: Soares RR, Razeghinejad MR. Efficacy of the combination of carteolol hydrochloride + latanoprost in the treatment of glaucoma and ocular hypertension. Expert Opin Pharmacother. 2018 Oct;19(15):1731-1738. doi: 10.1080/14656566.2018.1518432. Epub 2018 Oct 8. PMID: 30295543.
7: Drugs for common eye disorders. Med Lett Drugs Ther. 2019 Dec 2;61(1586):187-194. PMID: 31770361.
8: Kaji Y, Kiuchi T, Oshika T. Carteolol hydrochloride suppresses the generation of reactive oxygen species and rescues cell death after ultraviolet irradiation of cultured lens epithelial cells. Open Ophthalmol J. 2010 Oct 12;4:60-5. doi: 10.2174/1874364101004010060. PMID: 21283534; PMCID: PMC3031156.
9: Li T, Lindsley K, Rouse B, Hong H, Shi Q, Friedman DS, Wormald R, Dickersin K. Comparative Effectiveness of First-Line Medications for Primary Open-Angle Glaucoma: A Systematic Review and Network Meta-analysis. Ophthalmology. 2016 Jan;123(1):129-40. doi: 10.1016/j.ophtha.2015.09.005. Epub 2015 Oct 31. PMID: 26526633; PMCID: PMC4695285.
10: Higashiyama M, Tajika T, Inada K, Ohtori A. Improvement of the ocular bioavailability of carteolol by ion pair. J Ocul Pharmacol Ther. 2006 Oct;22(5):333-9. doi: 10.1089/jop.2006.22.333. PMID: 17076627.
