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MedKoo Cat#: 319711 | Name: Cindunistat HCl maleate

Description:

WARNING: This product is for research use only, not for human or veterinary use.

Cindunistat, also known as PHA-728669F, PF-00572986, PHA-84250, SD-6010 and SC-084250, is a potent and oral selective iNOS inhibitor. cindunistat is potentially useful in patients with symptomatic osteoarthritis of the knee.

Chemical Structure

Cindunistat HCl maleate
Cindunistat HCl maleate
CAS#753491-31-5 (HCl maleate)

Theoretical Analysis

MedKoo Cat#: 319711

Name: Cindunistat HCl maleate

CAS#: 753491-31-5 (HCl maleate)

Chemical Formula: C20H39ClN6O8S2

Exact Mass: 590.1959

Molecular Weight: 591.14

Elemental Analysis: C, 40.64; H, 6.65; Cl, 6.00; N, 14.22; O, 21.65; S, 10.85

Price and Availability

This product is currently not in stock but may be available through custom synthesis. To ensure cost efficiency, the minimum order quantity is 1 gram. The estimated lead time is 2 to 4 months, with pricing dependent on the complexity of the synthesis (typically high for intricate chemistries). Quotes for quantities below 1 gram will not be provided. To request a quote, please click the button below. Note: If this product becomes available in stock in the future, pricing will be listed accordingly.
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Related CAS #
753491-31-5 (HCl maleate) 364067-22-1 (free base)
Synonym
PHA-728669F; PHA 728669F; PHA728669F; SD-6010; SD 6010; SD6010; PF-00572986; PF00572986; PF 00572986; PF-572986; PF572986; PF 572986; PHA-84250; PHA84250; PHA 84250; SC-084250; SC 084250; SC084250; Cindunistat. cindunistat hydrochloride maleate
IUPAC/Chemical Name
(R,Z)-2-amino-3-((2-((1-aminoethylidene)amino)ethyl)thio)-2-methylpropanoic acid compound with maleic acid (2:1) hydrochloride
InChi Key
AXMATQOUTYMHRH-YYYPGOKWSA-N
InChi Code
InChI=1S/2C8H17N3O2S.C4H4O4.ClH/c2*1-6(9)11-3-4-14-5-8(2,10)7(12)13;5-3(6)1-2-4(7)8;/h2*3-5,10H2,1-2H3,(H2,9,11)(H,12,13);1-2H,(H,5,6)(H,7,8);1H/b;;2-1-;/t2*8-;;/m00../s1
SMILES Code
CC(=NCCSC[C@@](C)(C(=O)O)N)N.CC(=NCCSC[C@@](C)(C(=O)O)N)N.C(=C\C(=O)O)\C(=O)O.Cl
Appearance
Solid powder
Purity
>98% (or refer to the Certificate of Analysis)
Shipping Condition
Shipped under ambient temperature as non-hazardous chemical. This product is stable enough for a few weeks during ordinary shipping and time spent in Customs.
Storage Condition
Dry, dark and at 0 - 4 C for short term (days to weeks) or -20 C for long term (months to years).
Solubility
Soluble in DMSO, not in water
Shelf Life
>2 years if stored properly
Drug Formulation
This drug may be formulated in DMSO
Stock Solution Storage
0 - 4 C for short term (days to weeks), or -20 C for long term (months).
HS Tariff Code
2934.99.9001
More Info

Preparing Stock Solutions

The following data is based on the product molecular weight 591.14 Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which will affect the solvent volumes required to prepare stock solutions.

Recalculate based on batch purity %
Concentration / Solvent Volume / Mass 1 mg 5 mg 10 mg
1 mM 1.15 mL 5.76 mL 11.51 mL
5 mM 0.23 mL 1.15 mL 2.3 mL
10 mM 0.12 mL 0.58 mL 1.15 mL
50 mM 0.02 mL 0.12 mL 0.23 mL
1: Hellio le Graverand MP, Clemmer RS, Redifer P, Brunell RM, Hayes CW, Brandt KD, Abramson SB, Manning PT, Miller CG, Vignon E. A 2-year randomised, double-blind, placebo-controlled, multicentre study of oral selective iNOS inhibitor, cindunistat (SD-6010), in patients with symptomatic osteoarthritis of the knee. Ann Rheum Dis. 2013 Feb;72(2):187-95. doi: 10.1136/annrheumdis-2012-202239. Epub 2012 Nov 10. PubMed PMID: 23144445.