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MedKoo Cat#: 412909 | Name: Cindunistat (free base)

Description:

WARNING: This product is for research use only, not for human or veterinary use.

Cindunistat (free base) is an orally active inhibitor of inducible nitric oxide synthase (iNOS; also known as nitric oxide synthase type II)

Chemical Structure

Cindunistat (free base)
Cindunistat (free base)
CAS#364067-22-1 (free base)

Theoretical Analysis

MedKoo Cat#: 412909

Name: Cindunistat (free base)

CAS#: 364067-22-1 (free base)

Chemical Formula: C8H17N3O2S

Exact Mass: 219.1041

Molecular Weight: 219.30

Elemental Analysis: C, 43.82; H, 7.81; N, 19.16; O, 14.59; S, 14.62

Price and Availability

This product is currently not in stock but may be available through custom synthesis. To ensure cost efficiency, the minimum order quantity is 1 gram. The estimated lead time is 2 to 4 months, with pricing dependent on the complexity of the synthesis (typically high for intricate chemistries). Quotes for quantities below 1 gram will not be provided. To request a quote, please click the button below. Note: If this product becomes available in stock in the future, pricing will be listed accordingly.
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Related CAS #
753491-31-5 (HCl maleate) 364067-22-1 (free base)
Synonym
Cindunistat (free base); PHA84250; PHA 84250; PHA-84250
IUPAC/Chemical Name
(R)-3-((2-acetimidamidoethyl)thio)-2-amino-2-methylpropanoic acid
InChi Key
NWBJAUFHPXRBKI-QMMMGPOBSA-N
InChi Code
InChI=1S/C8H17N3O2S/c1-6(9)11-3-4-14-5-8(2,10)7(12)13/h3-5,10H2,1-2H3,(H2,9,11)(H,12,13)/t8-/m0/s1
SMILES Code
CC(NCCSC[C@](N)(C(O)=O)C)=N
Appearance
Solid powder
Purity
>98% (or refer to the Certificate of Analysis)
Shipping Condition
Shipped under ambient temperature as non-hazardous chemical. This product is stable enough for a few weeks during ordinary shipping and time spent in Customs.
Storage Condition
Dry, dark and at 0 - 4 C for short term (days to weeks) or -20 C for long term (months to years).
Solubility
Soluble in DMSO
Shelf Life
>2 years if stored properly
Drug Formulation
This drug may be formulated in DMSO
Stock Solution Storage
0 - 4 C for short term (days to weeks), or -20 C for long term (months).
HS Tariff Code
2934.99.9001
More Info

Preparing Stock Solutions

The following data is based on the product molecular weight 219.30 Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which will affect the solvent volumes required to prepare stock solutions.

Recalculate based on batch purity %
Concentration / Solvent Volume / Mass 1 mg 5 mg 10 mg
1 mM 1.15 mL 5.76 mL 11.51 mL
5 mM 0.23 mL 1.15 mL 2.3 mL
10 mM 0.12 mL 0.58 mL 1.15 mL
50 mM 0.02 mL 0.12 mL 0.23 mL
1: Gregori D, Giacovelli G, Minto C, Barbetta B, Gualtieri F, Azzolina D, Vaghi P, Rovati LC. Association of Pharmacological Treatments With Long-term Pain Control in Patients With Knee Osteoarthritis: A Systematic Review and Meta- analysis. JAMA. 2018 Dec 25;320(24):2564-2579. doi: 10.1001/jama.2018.19319. PMID: 30575881; PMCID: PMC6583519. 2: Hellio le Graverand MP, Clemmer RS, Redifer P, Brunell RM, Hayes CW, Brandt KD, Abramson SB, Manning PT, Miller CG, Vignon E. A 2-year randomised, double- blind, placebo-controlled, multicentre study of oral selective iNOS inhibitor, cindunistat (SD-6010), in patients with symptomatic osteoarthritis of the knee. Ann Rheum Dis. 2013 Feb;72(2):187-95. doi: 10.1136/annrheumdis-2012-202239. Epub 2012 Nov 10. PMID: 23144445.