Deferitazole, also known as FBS-0701 and SPD-602, is a new orally active Antimalarial iron chelator for the treatment of transfusional iron overload. Deferitazole displays a high affinity and selectivity for iron(III) as demonstrated by the log β2 = 33.39 ± 0.03 and the pFe(3+) value of 22.3. Deferitazole scavenges iron from labile sources such as citrate and albumin with efficiencies comparable with those of other therapeutic iron chelators, including deferasirox, deferiprone and desferrioxamine. FBS0701 blocks transmission by Plasmodium falciparum gametocyte.
MedKoo Cat#: 319691
Name: Deferitazole
CAS#: 945635-15-4 (free acid)
Chemical Formula: C18H25NO7S
Exact Mass: 399.1352
Molecular Weight: 399.46
Elemental Analysis: C, 54.12; H, 6.31; N, 3.51; O, 28.04; S, 8.03
The following data is based on the product molecular weight 399.46 Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which will affect the solvent volumes required to prepare stock solutions.
| Concentration / Solvent Volume / Mass | 1 mg | 5 mg | 10 mg |
|---|---|---|---|
| 1 mM | 1.15 mL | 5.76 mL | 11.51 mL |
| 5 mM | 0.23 mL | 1.15 mL | 2.3 mL |
| 10 mM | 0.12 mL | 0.58 mL | 1.15 mL |
| 50 mM | 0.02 mL | 0.12 mL | 0.23 mL |
