Synonym
SEP-225,289; SEP225,289; SEP225,289; SEP-225289; SEP225289; SEP225289;; Dasotraline; Dasotraline HCl; Dasotraline hydrochloride.
IUPAC/Chemical Name
(1R,4S)-4-(3,4-dichlorophenyl)-1,2,3,4-tetrahydronaphthalen-1-amine hydrochloride
InChi Key
YKXHIERZIRLOLD-DFIJPDEKSA-N
InChi Code
InChI=1S/C16H15Cl2N.ClH/c17-14-7-5-10(9-15(14)18)11-6-8-16(19)13-4-2-1-3-12(11)13;/h1-5,7,9,11,16H,6,8,19H2;1H/t11-,16+;/m0./s1
SMILES Code
N[C@@H]1CC[C@@H](C2=CC=C(Cl)C(Cl)=C2)C3=C1C=CC=C3.[H]Cl
Purity
>98% (or refer to the Certificate of Analysis)
Shipping Condition
Shipped under ambient temperature as non-hazardous chemical. This product is stable enough for a few weeks during ordinary shipping and time spent in Customs.
Storage Condition
Dry, dark and at 0 - 4 C for short term (days to weeks) or -20 C for long term (months to years).
Solubility
Soluble in DMSO, not in water
Shelf Life
>2 years if stored properly
Drug Formulation
This drug may be formulated in DMSO
Stock Solution Storage
0 - 4 C for short term (days to weeks), or -20 C for long term (months).
HS Tariff Code
2934.99.9001
More Info
Related CAS#
675126-05-3 (Dasotraline)
675126-08-6 (Dasotraline Hydrochloride)
Biological target:
Dasotraline hydrochloride (SEP-225289 hydrochloride) is a triple reuptake inhibitor that blocks dopamine, norepinephrine, and serotonin transporters with IC50 values of 4, 6, and 11 nM, respectively.
|
Solvent |
mg/mL |
mM |
| Solubility |
| DMSO |
31.0 |
94.32 |
Note: There can be variations in solubility for the same chemical from different vendors or different batches from the same vendor. The following factors can affect the solubility of the same chemical: solvent used for crystallization, residual solvent content, polymorphism, salt versus free form, degree of hydration, solvent temperature. Please use the solubility data as a reference only. Warming and sonication will facilitate dissolving. Still have questions? Please contact our Technical Support scientists.
Preparing Stock Solutions
The following data is based on the
product
molecular weight
328.66
Batch specific molecular weights may vary
from batch to batch
due to the degree of hydration, which will
affect the solvent
volumes required to prepare stock solutions.
| Concentration / Solvent Volume / Mass |
1 mg |
5 mg |
10 mg |
| 1 mM |
1.15 mL |
5.76 mL |
11.51 mL |
| 5 mM |
0.23 mL |
1.15 mL |
2.3 mL |
| 10 mM |
0.12 mL |
0.58 mL |
1.15 mL |
| 50 mM |
0.02 mL |
0.12 mL |
0.23 mL |
Formulation protocol:
TBD
1: Koblan KS, Hopkins SC, Sarma K, Gallina N, Jin F, Levy-Cooperman N, Schoedel
KA, Loebel A. Assessment of human abuse potential of dasotraline compared to
methylphenidate and placebo in recreational stimulant users. Drug Alcohol Depend.
2016 Feb 1;159:26-34. doi: 10.1016/j.drugalcdep.2015.10.029. Epub 2015 Dec 3.
PubMed PMID: 26794682.
2: Hopkins SC, Sunkaraneni S, Skende E, Hing J, Passarell JA, Loebel A, Koblan
KS. Pharmacokinetics and Exposure-Response Relationships of Dasotraline in the
Treatment of Attention-Deficit/Hyperactivity Disorder in Adults. Clin Drug
Investig. 2015 Nov 23. [Epub ahead of print] PubMed PMID: 26597180.
3: Koblan KS, Hopkins SC, Sarma K, Jin F, Goldman R, Kollins SH, Loebel A.
Dasotraline for the Treatment of Attention-Deficit/Hyperactivity Disorder: A
Randomized, Double-Blind, Placebo-Controlled, Proof-of-Concept Trial in Adults.
Neuropsychopharmacology. 2015 Nov;40(12):2745-52. doi: 10.1038/npp.2015.124. Epub
2015 May 7. PubMed PMID: 25948101.
