Synonym
TV-45070; TV 45070; TV45070; XEN402; XEN-402; XEN 402; Funapide.
IUPAC/Chemical Name
(3'S)-1'-{[5-(trifluoromethyl)furan-2-yl]methyl}-2H,6H-spiro[furo[2,3-f][1,3]benzodioxole-7,3'-indol]-2'(1'H)-one
InChi Key
NEBUOXBYNAHKFV-NRFANRHFSA-N
InChi Code
InChI=1S/C22H14F3NO5/c23-22(24,25)19-6-5-12(31-19)9-26-15-4-2-1-3-13(15)21(20(26)27)10-28-16-8-18-17(7-14(16)21)29-11-30-18/h1-8H,9-11H2/t21-/m0/s1
SMILES Code
O=C([C@]12COC3=C1C=C(OCO4)C4=C3)N(CC5=CC=C(C(F)(F)F)O5)C6=C2C=CC=C6
Purity
>98% (or refer to the Certificate of Analysis)
Shipping Condition
Shipped under ambient temperature as non-hazardous chemical. This product is stable enough for a few weeks during ordinary shipping and time spent in Customs.
Storage Condition
Dry, dark and at 0 - 4 C for short term (days to weeks) or -20 C for long term (months to years).
Solubility
Soluble in DMSO, not in water
Shelf Life
>2 years if stored properly
Drug Formulation
This drug may be formulated in DMSO
Stock Solution Storage
0 - 4 C for short term (days to weeks), or -20 C for long term (months).
HS Tariff Code
2934.99.9001
Preparing Stock Solutions
The following data is based on the
product
molecular weight
429.35
Batch specific molecular weights may vary
from batch to batch
due to the degree of hydration, which will
affect the solvent
volumes required to prepare stock solutions.
| Concentration / Solvent Volume / Mass |
1 mg |
5 mg |
10 mg |
| 1 mM |
1.15 mL |
5.76 mL |
11.51 mL |
| 5 mM |
0.23 mL |
1.15 mL |
2.3 mL |
| 10 mM |
0.12 mL |
0.58 mL |
1.15 mL |
| 50 mM |
0.02 mL |
0.12 mL |
0.23 mL |
1: Bagal SK, Chapman ML, Marron BE, Prime R, Storer RI, Swain NA. Recent progress
in sodium channel modulators for pain. Bioorg Med Chem Lett. 2014 Aug
15;24(16):3690-9. doi: 10.1016/j.bmcl.2014.06.038. Epub 2014 Jun 21. Review.
PubMed PMID: 25060923.
2: Goldberg YP, Pimstone SN, Namdari R, Price N, Cohen C, Sherrington RP, Hayden
MR. Human Mendelian pain disorders: a key to discovery and validation of novel
analgesics. Clin Genet. 2012 Oct;82(4):367-73. doi:
10.1111/j.1399-0004.2012.01942.x. Epub 2012 Aug 13. Review. PubMed PMID:
22845492.
3: Goldberg YP, Price N, Namdari R, Cohen CJ, Lamers MH, Winters C, Price J,
Young CE, Verschoof H, Sherrington R, Pimstone SN, Hayden MR. Treatment of
Na(v)1.7-mediated pain in inherited erythromelalgia using a novel sodium channel
blocker. Pain. 2012 Jan;153(1):80-5. doi: 10.1016/j.pain.2011.09.008. Epub 2011
Oct 28. PubMed PMID: 22035805.
4: Mai G, del Rio ML, Tian J, Ramirez P, Buhler L, Rodriguez-Barbosa JI. Blockade
of the PD-1/PD-1L pathway reverses the protective effect of anti-CD40L therapy in
a rat to mouse concordant islet xenotransplantation model. Xenotransplantation.
2007 May;14(3):243-8. PubMed PMID: 17489865.
