MedKoo Cat#: 530614 | Name: VU0364739 HCl
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Description:

WARNING: This product is for research use only, not for human or veterinary use.

VU0364739, also known as ML271, is a potent and selective allosteric PLD2 Inhibitor (cellular PLD1, IC50 = 1,500 nM, cellular PLD2, IC50 = 20 nM).

Chemical Structure

VU0364739 HCl
VU0364739 HCl
CAS#1244640-48-9 (HCl)

Theoretical Analysis

MedKoo Cat#: 530614

Name: VU0364739 HCl

CAS#: 1244640-48-9 (HCl)

Chemical Formula: C26H28ClFN4O2

Exact Mass: 0.0000

Molecular Weight: 482.98

Elemental Analysis: C, 64.66; H, 5.84; Cl, 7.34; F, 3.93; N, 11.60; O, 6.63

Price and Availability

Size Price Availability Quantity
25mg USD 550.00 2 Weeks
50mg USD 950.00 2 Weeks
100mg USD 1,650.00 2 Weeks
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Synonym
VU0364739; VU-0364739; VU 0364739; ML-271; ML271, ML 271; VU0364739 HCl; VU0364739 hydrochloride
IUPAC/Chemical Name
N-[2-[1-(3-fluorophenyl)-4-oxo-1,3,8-triazaspiro[4.5]decan-8-yl]ethyl]naphthalene-2-carboxamide hydrochloride
InChi Key
RYLAMDMOILNBKN-UHFFFAOYSA-N
InChi Code
InChI=1S/C26H27FN4O2.ClH/c27-22-6-3-7-23(17-22)31-18-29-25(33)26(31)10-13-30(14-11-26)15-12-28-24(32)21-9-8-19-4-1-2-5-20(19)16-21;/h1-9,16-17H,10-15,18H2,(H,28,32)(H,29,33);1H
SMILES Code
O=C(C1=CC=C2C=CC=CC2=C1)NCCN(CC3)CCC3(N(C4=CC=CC(F)=C4)CN5)C5=O.[H]Cl
Appearance
Solid powder
Purity
>98% (or refer to the Certificate of Analysis)
Shipping Condition
Shipped under ambient temperature as non-hazardous chemical. This product is stable enough for a few weeks during ordinary shipping and time spent in Customs.
Storage Condition
Dry, dark and at 0 - 4 C for short term (days to weeks) or -20 C for long term (months to years).
Solubility
Soluble in DMSO
Shelf Life
>2 years if stored properly
Drug Formulation
This drug may be formulated in DMSO
Stock Solution Storage
0 - 4 C for short term (days to weeks), or -20 C for long term (months).
HS Tariff Code
2934.99.9001
More Info

Preparing Stock Solutions

The following data is based on the product molecular weight 482.98 Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which will affect the solvent volumes required to prepare stock solutions.

Recalculate based on batch purity %
Concentration / Solvent Volume / Mass 1 mg 5 mg 10 mg
1 mM 1.15 mL 5.76 mL 11.51 mL
5 mM 0.23 mL 1.15 mL 2.3 mL
10 mM 0.12 mL 0.58 mL 1.15 mL
50 mM 0.02 mL 0.12 mL 0.23 mL
1: Scott SA, O’Reilly MC, Daniels JS, Morrison R, Ptak R, Dawson ES, Tower N, Engers JL, Engers DW, Oguin T, Thomas P, White L, Brown HA, Lindsley CW. Development of a Selective, Allosteric PLD2 Inhibitor. 2012 Apr 5 [updated 2013 Mar 14]. Probe Reports from the NIH Molecular Libraries Program [Internet]. Bethesda (MD): National Center for Biotechnology Information (US); 2010-. Available from http://www.ncbi.nlm.nih.gov/books/NBK143549/PubMed PMID: 23762931.