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MedKoo Cat#: 317882 | Name: Flumazenil
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Description:

WARNING: This product is for research use only, not for human or veterinary use.

Flumazenil is a specific benzodiazepine receptor antagonist primarily administered by injection. It is the only benzodiazepine receptor antagonist on the market today. Flumazenil is of benefit in patients who become excessively drowsy after benzodiazepines are used for either diagnostic or therapeutic procedures and it has been used as an antidote in the treatment of benzodiazepine overdoses.

Chemical Structure

Flumazenil
Flumazenil
CAS#78755-81-4

Theoretical Analysis

MedKoo Cat#: 317882

Name: Flumazenil

CAS#: 78755-81-4

Chemical Formula: C15H14FN3O3

Exact Mass: 303.1019

Molecular Weight: 303.29

Elemental Analysis: C, 59.40; H, 4.65; F, 6.26; N, 13.85; O, 15.83

Price and Availability

Size Price Availability Quantity
50mg USD 450.00 2 Weeks
100mg USD 750.00 2 Weeks
200mg USD 1,250.00 2 Weeks
500mg USD 2,450.00 2 Weeks
1g USD 3,750.00 2 Weeks
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Related CAS #
No Data
Synonym
Flumazenil; Flumazepil; Anexate; Romazicon; Lanexat; Ro 15-1788; Ro15-1788; Ro-15-1788; Ro-151788; Ro151788; Ro 151788
IUPAC/Chemical Name
ethyl 8-fluoro-5-methyl-6-oxo-4H-imidazo[1,5-a][1,4]benzodiazepine-3-carboxylate
InChi Key
OFBIFZUFASYYRE-UHFFFAOYSA-N
InChi Code
InChI=1S/C15H14FN3O3/c1-3-22-15(21)13-12-7-18(2)14(20)10-6-9(16)4-5-11(10)19(12)8-17-13/h4-6,8H,3,7H2,1-2H3
SMILES Code
O=C(C1=C(CN2C)N(C=N1)C3=CC=C(F)C=C3C2=O)OCC
Appearance
White to off-white solid powder.
Purity
>98% (or refer to the Certificate of Analysis)
Shipping Condition
Shipped under ambient temperature as non-hazardous chemical. This product is stable enough for a few weeks during ordinary shipping and time spent in Customs.
Storage Condition
Dry, dark and at 0 - 4 C for short term (days to weeks) or -20 C for long term (months to years).
Solubility
Soluble in DMSO, not in water
Shelf Life
>2 years if stored properly
Drug Formulation
This drug may be formulated in DMSO
Stock Solution Storage
0 - 4 C for short term (days to weeks), or -20 C for long term (months).
HS Tariff Code
2934.99.9001
More Info

Preparing Stock Solutions

The following data is based on the product molecular weight 303.29 Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which will affect the solvent volumes required to prepare stock solutions.

Recalculate based on batch purity %
Concentration / Solvent Volume / Mass 1 mg 5 mg 10 mg
1 mM 1.15 mL 5.76 mL 11.51 mL
5 mM 0.23 mL 1.15 mL 2.3 mL
10 mM 0.12 mL 0.58 mL 1.15 mL
50 mM 0.02 mL 0.12 mL 0.23 mL
1: Penninga EI, Graudal N, Ladekarl MB, Jürgens G. Adverse Events Associated with Flumazenil Treatment for the Management of Suspected Benzodiazepine Intoxication - A Systematic Review with Meta-Analyses of Randomised Trials. Basic Clin Pharmacol Toxicol. 2016 Jan;118(1):37-44. doi: 10.1111/bcpt.12434. Epub 2015 Jul 28. Review. PubMed PMID: 26096314. 2: Sivilotti ML. Flumazenil, naloxone and the 'coma cocktail'. Br J Clin Pharmacol. 2015 Aug 7. doi: 10.1111/bcp.12731. [Epub ahead of print] Review. PubMed PMID: 26469689. 3: Möhler H. The legacy of the benzodiazepine receptor: from flumazenil to enhancing cognition in Down syndrome and social interaction in autism. Adv Pharmacol. 2015;72:1-36. doi: 10.1016/bs.apha.2014.10.008. Epub 2014 Dec 30. Review. PubMed PMID: 25600365. 4: Hood SD, Norman A, Hince DA, Melichar JK, Hulse GK. Benzodiazepine dependence and its treatment with low dose flumazenil. Br J Clin Pharmacol. 2014 Feb;77(2):285-94. doi: 10.1111/bcp.12023. Review. PubMed PMID: 23126253; PubMed Central PMCID: PMC4014019. 5: Iseki K. [Flumazenil]. Chudoku Kenkyu. 2008 Oct;21(4):373-8. Review. Japanese. PubMed PMID: 19069130. 6: Hammers A. Flumazenil positron emission tomography and other ligands for functional imaging. Neuroimaging Clin N Am. 2004 Aug;14(3):537-51. Review. PubMed PMID: 15324863. 7: Weinbroum AA, Szold O, Ogorek D, Flaishon R. The midazolam-induced paradox phenomenon is reversible by flumazenil. Epidemiology, patient characteristics and review of the literature. Eur J Anaesthesiol. 2001 Dec;18(12):789-97. Review. PubMed PMID: 11737177. 8: Fulton SA, Mullen KD. Completion of upper endoscopic procedures despite paradoxical reaction to midazolam: a role for flumazenil? Am J Gastroenterol. 2000 Mar;95(3):809-11. Review. PubMed PMID: 10710082. 9: Mullins ME. First-degree atrioventricular block in alprazolam overdose reversed by flumazenil. J Pharm Pharmacol. 1999 Mar;51(3):367-70. Review. PubMed PMID: 10344640. 10: Davis DP, Hamilton RS, Webster TH. Reversal of midazolam-induced laryngospasm with flumazenil. Ann Emerg Med. 1998 Aug;32(2):263-5. Review. PubMed PMID: 9701315. 11: Boccuzzi-Chmura L, Robertson DC. Flumazenil (romazicon) and the patient with benzodiazepine overdose: risks versus benefits. J Emerg Nurs. 1996 Aug;22(4):330-3. Review. PubMed PMID: 8936146. 12: Malizia AL, Nutt DJ. The effects of flumazenil in neuropsychiatric disorders. Clin Neuropharmacol. 1995 Jun;18(3):215-32. Review. PubMed PMID: 8635180. 13: Clark RF, Sage TA, Tunget C, Manoguerra AS. Delayed onset lorazepam poisoning successfully reversed by flumazenil in a child. Case report and review of the literature. Pediatr Emerg Care. 1995 Feb;11(1):32-4. Review. PubMed PMID: 7739960. 14: Rodrigo C. Flumazenil in dentistry. Anesth Prog. 1995;42(3-4):121-5. Review. PubMed PMID: 8934978; PubMed Central PMCID: PMC2148898. 15: Whitwam JG, Amrein R. Pharmacology of flumazenil. Acta Anaesthesiol Scand Suppl. 1995;108:3-14. Review. PubMed PMID: 8693922. 16: Whitwam JG. Flumazenil and midazolam in anaesthesia. Acta Anaesthesiol Scand Suppl. 1995;108:15-22. Review. PubMed PMID: 8693920. 17: Plant JR, MacLeod DB. Response of a promethazine-induced coma to flumazenil. Ann Emerg Med. 1994 Nov;24(5):979-82. Review. PubMed PMID: 7978578. 18: Doyon S, Roberts JR. Reappraisal of the "coma cocktail". Dextrose, flumazenil, naloxone, and thiamine. Emerg Med Clin North Am. 1994 May;12(2):301-16. Review. PubMed PMID: 8187685. 19: Cone AM, Stott SA. Flumazenil. Br J Hosp Med. 1994 Apr 6-19;51(7):346-8. Review. PubMed PMID: 8081564. 20: Sugarman JM, Paul RI. Flumazenil: a review. Pediatr Emerg Care. 1994 Feb;10(1):37-43. Review. PubMed PMID: 8177806.