GO-Y078 | CAS# 1217503-60-0 | Antiangiogenic Curcumin Analog

MedKoo Cat#: 564897 | Name: GO-Y078

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Description:

WARNING: This product is for research use only, not for human or veterinary use.

GO-Y078 is an antiangiogenic curcumin analog which inhibits actin stress fiber formation, thereby resulting in mobility inhibition.

Chemical Structure

GO-Y078

CAS#1217503-60-0

Theoretical Analysis

MedKoo Cat#: 564897

Name: GO-Y078

CAS#: 1217503-60-0

Chemical Formula: C22H24O7

Exact Mass: 400.1522

Molecular Weight: 400.43

Elemental Analysis: C, 65.99; H, 6.04; O, 27.97

Price and Availability

Size	Price	Availability	Quantity
20mg	USD 370.00	2 Weeks
100mg	USD 850.00	2 Weeks

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Related CAS #

No Data

Synonym

GOY078; GO Y078; GO-Y078

IUPAC/Chemical Name

(1E,4E)-1-(4-Hydroxy-3,5-dimethoxyphenyl)-5-(3,4,5-trimethoxyphenyl)penta-1,4-dien-3-one

InChi Key

SKZNJIJSGSQNJQ-CDJQDVQCSA-N

InChi Code

InChI=1S/C22H24O7/c1-25-17-10-14(11-18(26-2)21(17)24)6-8-16(23)9-7-15-12-19(27-3)22(29-5)20(13-15)28-4/h6-13,24H,1-5H3/b8-6+,9-7+

SMILES Code

O=C(/C=C/C1=CC(OC)=C(OC)C(OC)=C1)/C=C/C2=CC(OC)=C(O)C(OC)=C2

Appearance

Solid powder

Purity

>95% (or refer to the Certificate of Analysis)

Shipping Condition

Shipped under ambient temperature as non-hazardous chemical. This product is stable enough for a few weeks during ordinary shipping and time spent in Customs.

Storage Condition

Dry, dark and at 0 - 4 C for short term (days to weeks) or -20 C for long term (months to years).

Solubility

Soluble in DMSO

Shelf Life

>3 years if stored properly

Drug Formulation

This drug may be formulated in DMSO

Stock Solution Storage

0 - 4 C for short term (days to weeks), or -20 C for long term (months).

HS Tariff Code

2934.99.9001

More Info

Instruction

View handling instruction

Preparing Stock Solutions

The following data is based on the product molecular weight 400.43 Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which will affect the solvent volumes required to prepare stock solutions.

Concentration / Solvent Volume / Mass	1 mg	5 mg	10 mg
1 mM	1.15 mL	5.76 mL	11.51 mL
5 mM	0.23 mL	1.15 mL	2.3 mL
10 mM	0.12 mL	0.58 mL	1.15 mL
50 mM	0.02 mL	0.12 mL	0.23 mL

1: Shimazu K, Inoue M, Sugiyama S, Fukuda K, Yoshida T, Taguchi D, Uehara Y, Kuriyama S, Tanaka M, Miura M, Nanjyo H, Iwabuchi Y, Shibata H. Curcumin analog, GO-Y078, overcomes resistance to tumor angiogenesis inhibitors. Cancer Sci. 2018 Oct;109(10):3285-3293. doi: 10.1111/cas.13741. Epub 2018 Aug 16. PubMed PMID: 30024080; PubMed Central PMCID: PMC6172066. 2: Murakami M, Ohnuma S, Fukuda M, Chufan EE, Kudoh K, Kanehara K, Sugisawa N, Ishida M, Naitoh T, Shibata H, Iwabuchi Y, Ambudkar SV, Unno M. Synthetic Analogs of Curcumin Modulate the Function of Multidrug Resistance-Linked ATP-Binding Cassette Transporter ABCG2. Drug Metab Dispos. 2017 Nov;45(11):1166-1177. doi: 10.1124/dmd.117.076000. Epub 2017 Sep 13. PubMed PMID: 28904007; PubMed Central PMCID: PMC5637816. 3: Sugiyama S, Yoshino Y, Kuriyama S, Inoue M, Komine K, Otsuka K, Kohyama A, Yamakoshi H, Ishioka C, Tanaka M, Iwabuchi Y, Shibata H. A Curcumin Analog, GO-Y078, Effectively Inhibits Angiogenesis through Actin Disorganization. Anticancer Agents Med Chem. 2016;16(5):633-47. PubMed PMID: 26459768. 4: Kudo C, Yamakoshi H, Sato A, Ohori H, Ishioka C, Iwabuchi Y, Shibata H. Novel curcumin analogs, GO-Y030 and GO-Y078, are multi-targeted agents with enhanced abilities for multiple myeloma. Anticancer Res. 2011 Nov;31(11):3719-26. PubMed PMID: 22110192. 5: Kudo C, Yamakoshi H, Sato A, Nanjo H, Ohori H, Ishioka C, Iwabuchi Y, Shibata H. Synthesis of 86 species of 1,5-diaryl-3-oxo-1,4-pentadienes analogs of curcumin can yield a good lead in vivo. BMC Pharmacol. 2011 May 28;11:4. doi: 10.1186/1471-2210-11-4. PubMed PMID: 21619659; PubMed Central PMCID: PMC3115866.

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