Synonym
DAA; Deacetylasperulosidic Acid
IUPAC/Chemical Name
(1S,4aS,5S,7aS)-5-Hydroxy-7-(hydroxymethyl)-1-[(2S,3R,4S,5S,6R)-3,4,5-trihydroxy-6-(hydroxymethyl)oxan-2-yl]oxy-1,4a,5,7a-tetrahydrocyclopenta[c]pyran-4-carboxylic acid
InChi Key
ZVXWFPTVHBWJOU-YYFGDFGFSA-N
InChi Code
InChI=1S/C16H22O11/c17-2-5-1-7(19)10-6(14(23)24)4-25-15(9(5)10)27-16-13(22)12(21)11(20)8(3-18)26-16/h1,4,7-13,15-22H,2-3H2,(H,23,24)/t7-,8+,9+,10-,11+,12-,13+,15-,16-/m0/s1
SMILES Code
O=C(C1=CO[C@@H](O[C@@H]2O[C@H](CO)[C@@H](O)[C@H](O)[C@H]2O)[C@@]3([H])[C@]1([H])[C@@H](O)C=C3CO)O
Purity
>98% (or refer to the Certificate of Analysis)
Shipping Condition
Shipped under ambient temperature as non-hazardous chemical. This product is stable enough for a few weeks during ordinary shipping and time spent in Customs.
Storage Condition
Dry, dark and at 0 - 4 C for short term (days to weeks) or -20 C for long term (months to years).
Solubility
Soluble in DMSO
Shelf Life
>3 years if stored properly
Drug Formulation
This drug may be formulated in DMSO
Stock Solution Storage
0 - 4 C for short term (days to weeks), or -20 C for long term (months).
HS Tariff Code
2934.99.03.00
Preparing Stock Solutions
The following data is based on the
product
molecular weight
390.34
Batch specific molecular weights may vary
from batch to batch
due to the degree of hydration, which will
affect the solvent
volumes required to prepare stock solutions.
| Concentration / Solvent Volume / Mass |
1 mg |
5 mg |
10 mg |
| 1 mM |
1.15 mL |
5.76 mL |
11.51 mL |
| 5 mM |
0.23 mL |
1.15 mL |
2.3 mL |
| 10 mM |
0.12 mL |
0.58 mL |
1.15 mL |
| 50 mM |
0.02 mL |
0.12 mL |
0.23 mL |
1: Li C, Dong J, Tian J, Deng Z, Song X. LC/MS/MS determination and pharmacokinetic study of iridoid glycosides monotropein and deacetylasperulosidic acid isomers in rat plasma after oral administration of Morinda officinalis extract. Biomed Chromatogr. 2016 Feb;30(2):163-8. doi: 10.1002/bmc.3532. Epub 2015 Jul 2. PubMed PMID: 26053360.
2: Almeida-Souza F, Cardoso Fde O, Souza BV, do Valle TZ, de Sá JC, Oliveira Idos S, de Souza Cda S, Moragas Tellis CJ, Chagas Mdo S, Behrens MD, Abreu-Silva AL, Calabrese Kda S. Morinda citrifolia Linn. Reduces Parasite Load and Modulates Cytokines and Extracellular Matrix Proteins in C57BL/6 Mice Infected with Leishmania (Leishmania) amazonensis. PLoS Negl Trop Dis. 2016 Aug 31;10(8):e0004900. doi: 10.1371/journal.pntd.0004900. eCollection 2016 Aug. PubMed PMID: 27579922; PubMed Central PMCID: PMC5006983.
3: Liu Q, Zhao HW, Zhang AH, Sun H, Zhao XH, Nan Y, Kong L, Guan Y, Zou SY, Ma ZH, Wang XJ. [Chinmedomics strategy to discover effective constituents and elucidate action mechanism of Nanshi capsule against kidney-yang deficiency syndrome]. Zhongguo Zhong Yao Za Zhi. 2016 Aug;41(15):2901-2914. doi: 10.4268/cjcmm20161526. Chinese. PubMed PMID: 28914036.
4: Heffels P, Müller L, Schieber A, Weber F. Profiling of iridoid glycosides in Vaccinium species by UHPLC-MS. Food Res Int. 2017 Oct;100(Pt 3):462-468. doi: 10.1016/j.foodres.2016.11.018. Epub 2016 Nov 18. PubMed PMID: 28964369.
5: Tran PH, Le VD, Do TH, Nguyen TL, Nguyen PT, Nguyen TT, Nguyen TD. Anti-inflammatory constituents from Psychotria prainii H. Lév. Nat Prod Res. 2017 Dec 6:1-6. doi: 10.1080/14786419.2017.1408095. [Epub ahead of print] PubMed PMID: 29212359.
