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MedKoo Cat#: 317868 | Name: Fenoprofen
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Description:

WARNING: This product is for research use only, not for human or veterinary use.

Fenoprofen is a non-steroidal anti-inflammatory drug. Fenoprofen calcium is used for symptomatic relief for rheumatoid arthritis, osteoarthritis, and mild to moderate pain. Fenoprofen blocks the enzymes that make prostaglandins (cyclooxygenases), resulting in lower concentrations of prostaglandins. As a consequence, inflammation, swelling, pain and fever are reduced.

Chemical Structure

Fenoprofen
Fenoprofen
CAS#29679-58-1 (free acid)

Theoretical Analysis

MedKoo Cat#: 317868

Name: Fenoprofen

CAS#: 29679-58-1 (free acid)

Chemical Formula: C15H14O3

Exact Mass: 242.0943

Molecular Weight: 242.27

Elemental Analysis: C, 74.36; H, 5.82; O, 19.81

Price and Availability

Size Price Availability Quantity
250mg USD 250.00 2 Weeks
1g USD 550.00 2 Weeks
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Related CAS #
29679-58-1 (free acid) 34597-40-5 (calcium) 71720-56-4 (hydrate)
Synonym
Fenoprofen; Fenoprofenum; (±)-Fenoprofen; Fenoprofene; Fenoprofeno; Nalfon; Lilly 53858; Lilly53858; Lilly-53858; NSC-757813; NSC757813; NSC 757813
IUPAC/Chemical Name
2-(3-phenoxyphenyl)propanoic acid
InChi Key
RDJGLLICXDHJDY-UHFFFAOYSA-N
InChi Code
InChI=1S/C15H14O3/c1-11(15(16)17)12-6-5-9-14(10-12)18-13-7-3-2-4-8-13/h2-11H,1H3,(H,16,17)
SMILES Code
CC(C1=CC=CC(OC2=CC=CC=C2)=C1)C(O)=O
Appearance
Solid powder
Purity
>98% (or refer to the Certificate of Analysis)
Shipping Condition
Shipped under ambient temperature as non-hazardous chemical. This product is stable enough for a few weeks during ordinary shipping and time spent in Customs.
Storage Condition
Dry, dark and at 0 - 4 C for short term (days to weeks) or -20 C for long term (months to years).
Solubility
Soluble in DMSO, not in water
Shelf Life
>2 years if stored properly
Drug Formulation
This drug may be formulated in DMSO
Stock Solution Storage
0 - 4 C for short term (days to weeks), or -20 C for long term (months).
HS Tariff Code
2934.99.9001
More Info

Preparing Stock Solutions

The following data is based on the product molecular weight 242.27 Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which will affect the solvent volumes required to prepare stock solutions.

Recalculate based on batch purity %
Concentration / Solvent Volume / Mass 1 mg 5 mg 10 mg
1 mM 1.15 mL 5.76 mL 11.51 mL
5 mM 0.23 mL 1.15 mL 2.3 mL
10 mM 0.12 mL 0.58 mL 1.15 mL
50 mM 0.02 mL 0.12 mL 0.23 mL
1: Kyle ME, Wang JC, Shin JJ. Impact of nonaspirin nonsteroidal anti-inflammatory agents and acetaminophen on sensorineural hearing loss: a systematic review. Otolaryngol Head Neck Surg. 2015 Mar;152(3):393-409. doi: 10.1177/0194599814564533. Epub 2015 Jan 5. Review. PubMed PMID: 25560405; PubMed Central PMCID: PMC4465569. 2: Yin JB, Cui GB, Mi MS, Du YX, Wu SX, Li YQ, Wang W. Local infiltration analgesia for postoperative pain after hip arthroplasty: a systematic review and meta-analysis. J Pain. 2014 Aug;15(8):781-99. doi: 10.1016/j.jpain.2014.03.002. Epub 2014 Apr 5. Review. PubMed PMID: 24709160. 3: Nakata K. [Development of novel methods for preparing chiral non-steroidal anti-inflammatory drugs (NSAIDs) by asymmetric esterification]. Yakugaku Zasshi. 2012;132(9):993-1000. Review. Japanese. PubMed PMID: 23023415. 4: Holland S, Silberstein SD, Freitag F, Dodick DW, Argoff C, Ashman E; Quality Standards Subcommittee of the American Academy of Neurology and the American Headache Society. Evidence-based guideline update: NSAIDs and other complementary treatments for episodic migraine prevention in adults: report of the Quality Standards Subcommittee of the American Academy of Neurology and the American Headache Society. Neurology. 2012 Apr 24;78(17):1346-53. doi: 10.1212/WNL.0b013e3182535d0c. Review. PubMed PMID: 22529203; PubMed Central PMCID: PMC3335449. 5: Jaturapatporn D, Isaac MG, McCleery J, Tabet N. Aspirin, steroidal and non-steroidal anti-inflammatory drugs for the treatment of Alzheimer's disease. Cochrane Database Syst Rev. 2012 Feb 15;2:CD006378. doi: 10.1002/14651858.CD006378.pub2. Review. PubMed PMID: 22336816. 6: Sivaprasad S, Bunce C, Crosby-Nwaobi R. Non-steroidal anti-inflammatory agents for treating cystoid macular oedema following cataract surgery. Cochrane Database Syst Rev. 2012 Feb 15;2:CD004239. doi: 10.1002/14651858.CD004239.pub3. Review. PubMed PMID: 22336801. 7: Traa MX, Derry S, Moore RA. Single dose oral fenoprofen for acute postoperative pain in adults. Cochrane Database Syst Rev. 2011 Feb 16;(2):CD007556. doi: 10.1002/14651858.CD007556.pub2. Review. PubMed PMID: 21328296; PubMed Central PMCID: PMC4171001. 8: Ganapathy V, Thangaraju M, Gopal E, Martin PM, Itagaki S, Miyauchi S, Prasad PD. Sodium-coupled monocarboxylate transporters in normal tissues and in cancer. AAPS J. 2008;10(1):193-9. doi: 10.1208/s12248-008-9022-y. Epub 2008 Apr 2. Review. PubMed PMID: 18446519; PubMed Central PMCID: PMC2751467. 9: Sivaprasad S, Bunce C, Wormald R. Non-steroidal anti-inflammatory agents for cystoid macular oedema following cataract surgery: a systematic review. Br J Ophthalmol. 2005 Nov;89(11):1420-2. Review. PubMed PMID: 16234444; PubMed Central PMCID: PMC1772909. 10: Stevenson CL, Bennett DB, Lechuga-Ballesteros D. Pharmaceutical liquid crystals: the relevance of partially ordered systems. J Pharm Sci. 2005 Sep;94(9):1861-80. Review. PubMed PMID: 16052511. 11: Bunjes H, Rades T. Thermotropic liquid crystalline drugs. J Pharm Pharmacol. 2005 Jul;57(7):807-16. Review. PubMed PMID: 15969938. 12: Sivaprasad S, Bunce C, Patel N. Non-steroidal anti-inflammatory agents for treating cystoid macular oedema following cataract surgery. Cochrane Database Syst Rev. 2005 Jan 25;(1):CD004239. Review. Update in: Cochrane Database Syst Rev. 2012;2:CD004241. Cochrane Database Syst Rev. 2012;2:CD004239. PubMed PMID: 15674935. 13: Kantoci D, Wechter WJ. Calculation of inversion half-lives of aryl propionic acid class nonsteroidal antiinflammatory drugs. J Clin Pharmacol. 1996 Jun;36(6):500-4. Review. PubMed PMID: 8809634. 14: Wechter WJ. Drug chirality: on the mechanism of R-aryl propionic acid class NSAIDs. Epimerization in humans and the clinical implications for the use of racemates. J Clin Pharmacol. 1994 Nov;34(11):1036-42. Review. PubMed PMID: 7876392. 15: Lapicque F, Muller N, Payan E, Dubois N, Netter P. Protein binding and stereoselectivity of nonsteroidal anti-inflammatory drugs. Clin Pharmacokinet. 1993 Aug;25(2):115-23. Review. PubMed PMID: 8403735. 16: Murray MD, Brater DC. Renal toxicity of the nonsteroidal anti-inflammatory drugs. Annu Rev Pharmacol Toxicol. 1993;33:435-65. Review. PubMed PMID: 8494347. 17: Goodwin SD, Glenny RW. Nonsteroidal anti-inflammatory drug-associated pulmonary infiltrates with eosinophilia. Review of the literature and Food and Drug Administration Adverse Drug Reaction reports. Arch Intern Med. 1992 Jul;152(7):1521-4. Review. PubMed PMID: 1627033. 18: Pradalier A, Vincent D. [Migraine and non-steroidal anti-inflammatory agents]. Pathol Biol (Paris). 1992 Apr;40(4):397-405. Review. French. PubMed PMID: 1495823. 19: Skeith KJ, Jamali F. Clinical pharmacokinetics of drugs used in juvenile arthritis. Clin Pharmacokinet. 1991 Aug;21(2):129-49. Review. PubMed PMID: 1884567. 20: Miller LG, Prichard JG. Current issues in NSAID therapy. Prim Care. 1990 Sep;17(3):589-601. Review. PubMed PMID: 2236338.

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