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MedKoo Cat#: 526630 | Name: Fenoprofen Calcium Dihydrate
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Description:

WARNING: This product is for research use only, not for human or veterinary use.

Fenoprofen Calcium Dihydrate is a non-steroidal anti-inflammatory drug, being used for symptomatic relief for rheumatoid arthritis, osteoarthritis, and mild to moderate pain.

Chemical Structure

Fenoprofen Calcium Dihydrate
Fenoprofen Calcium Dihydrate
CAS#71720-56-4 (hydrate)

Theoretical Analysis

MedKoo Cat#: 526630

Name: Fenoprofen Calcium Dihydrate

CAS#: 71720-56-4 (hydrate)

Chemical Formula: C30H30CaO8

Exact Mass: 0.0000

Molecular Weight: 558.64

Elemental Analysis: C, 64.50; H, 5.41; Ca, 7.17; O, 22.91

Price and Availability

Size Price Availability Quantity
1g USD 250.00 2 Weeks
5g USD 550.00 2 Weeks
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Related CAS #
29679-58-1 (free acid) 34597-40-5 (calcium) 71720-56-4 (hydrate)
Synonym
Fenoprofen calcium dihydrate; Nalgesic; Fenoprofen calcium hydrate;
IUPAC/Chemical Name
Calcium 2-(3-phenoxyphenyl)propanoate dihydrate
InChi Key
LZPBLUATTGKZBH-UHFFFAOYSA-L
InChi Code
InChI=1S/2C15H14O3.Ca.2H2O/c2*1-11(15(16)17)12-6-5-9-14(10-12)18-13-7-3-2-4-8-13;;;/h2*2-11H,1H3,(H,16,17);;2*1H2/q;;+2;;/p-2
SMILES Code
CC(C1=CC=CC(OC2=CC=CC=C2)=C1)C([O-])=O.CC(C3=CC=CC(OC4=CC=CC=C4)=C3)C([O-])=O.[H]O[H].[H]O[H].[Ca+2]
Appearance
Solid powder
Purity
>98% (or refer to the Certificate of Analysis)
Shipping Condition
Shipped under ambient temperature as non-hazardous chemical. This product is stable enough for a few weeks during ordinary shipping and time spent in Customs.
Storage Condition
Dry, dark and at 0 - 4 C for short term (days to weeks) or -20 C for long term (months to years).
Solubility
Soluble in DMSO
Shelf Life
>2 years if stored properly
Drug Formulation
This drug may be formulated in DMSO
Stock Solution Storage
0 - 4 C for short term (days to weeks), or -20 C for long term (months).
HS Tariff Code
2934.99.9001
More Info

Preparing Stock Solutions

The following data is based on the product molecular weight 558.64 Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which will affect the solvent volumes required to prepare stock solutions.

Recalculate based on batch purity %
Concentration / Solvent Volume / Mass 1 mg 5 mg 10 mg
1 mM 1.15 mL 5.76 mL 11.51 mL
5 mM 0.23 mL 1.15 mL 2.3 mL
10 mM 0.12 mL 0.58 mL 1.15 mL
50 mM 0.02 mL 0.12 mL 0.23 mL
1: Tang Y, Guo LL, Hong CY, Bing YX, Xu ZC. Seasonal occurrence, removal and risk assessment of 10 pharmaceuticals in 2 sewage treatment plants of Guangdong, China. Environ Technol. 2017 Nov 10:1-12. doi: 10.1080/09593330.2017.1397758. [Epub ahead of print] PubMed PMID: 29069966. 2: Mohamed ME, Frag EYZ, Hathoot AA, Shalaby EA. Spectrophotometric determination of fenoprofen calcium drug in pure and pharmaceutical preparations. Spectroscopic characterization of the charge transfer solid complexes. Spectrochim Acta A Mol Biomol Spectrosc. 2018 Jan 15;189:357-365. doi: 10.1016/j.saa.2017.08.027. Epub 2017 Aug 10. PubMed PMID: 28830039. 3: Eccleston C, Cooper TE, Fisher E, Anderson B, Wilkinson NM. Non-steroidal anti-inflammatory drugs (NSAIDs) for chronic non-cancer pain in children and adolescents. Cochrane Database Syst Rev. 2017 Aug 2;8:CD012537. doi: 10.1002/14651858.CD012537.pub2. Review. PubMed PMID: 28770976. 4: Ammar HO, Makram TS, Mosallam S. Effect of Polymers on the Physicochemical Properties and Biological Performance of Fenoprofen Calcium Dihydrate-Triacetyl-β-Cyclodextrin Complex. Pharmaceutics. 2017 Jul 3;9(3). pii: E23. doi: 10.3390/pharmaceutics9030023. PubMed PMID: 28671624; PubMed Central PMCID: PMC5620564. 5: Tran NH, Gin KY. Occurrence and removal of pharmaceuticals, hormones, personal care products, and endocrine disrupters in a full-scale water reclamation plant. Sci Total Environ. 2017 Dec 1;599-600:1503-1516. doi: 10.1016/j.scitotenv.2017.05.097. Epub 2017 May 17. PubMed PMID: 28531959. 6: Madikizela LM, Tavengwa NT, Chimuka L. Applications of molecularly imprinted polymers for solid-phase extraction of non-steroidal anti-inflammatory drugs and analgesics from environmental waters and biological samples. J Pharm Biomed Anal. 2018 Jan 5;147:624-633. doi: 10.1016/j.jpba.2017.04.010. Epub 2017 Apr 23. Review. PubMed PMID: 28477973. 7: Farghaly DA, Aboelwafa AA, Hamza MY, Mohamed MI. Topical Delivery of Fenoprofen Calcium via Elastic Nano-vesicular Spanlastics: Optimization Using Experimental Design and In Vivo Evaluation. AAPS PharmSciTech. 2017 Nov;18(8):2898-2909. doi: 10.1208/s12249-017-0771-8. Epub 2017 Apr 20. PubMed PMID: 28429293. 8: Farghaly DA, Aboelwafa AA, Hamza MY, Mohamed MI. Microemulsion for topical delivery of fenoprofen calcium: in vitro and in vivo evaluation. J Liposome Res. 2017 Feb 6:1-11. doi: 10.1080/08982104.2017.1281951. [Epub ahead of print] PubMed PMID: 28081643. 9: Kameshwar VH, R KJ, Priya BS, Swamy SN. Synthesis, characterization and bioactivity studies of novel 1,3,4-oxadiazole small molecule that targets basic phospholipase A(2) from Vipera russelli. Mol Cell Biochem. 2017 Feb;426(1-2):161-175. doi: 10.1007/s11010-016-2888-6. Epub 2016 Dec 7. PubMed PMID: 27928710. 10: Montero-Melendez T, Forfar RA, Cook JM, Jerman JC, Taylor DL, Perretti M. Old drugs with new skills: fenoprofen as an allosteric enhancer at melanocortin receptor 3. Cell Mol Life Sci. 2017 Apr;74(7):1335-1345. doi: 10.1007/s00018-016-2419-3. Epub 2016 Nov 16. PubMed PMID: 27853832; PubMed Central PMCID: PMC5346439. 11: Martin DF, Martin JM, Word TA. Removal of selected NSAIDs (nonsteroidal anti-inflammatory drugs) in aqueous samples by Octolig®. J Environ Sci Health A Tox Hazard Subst Environ Eng. 2016 Jan 28;51(2):186-191. Epub 2015 Nov 25. Erratum in: J Environ Sci Health A Tox Hazard Subst Environ Eng. 2016 Nov 9;51(13):1195. PubMed PMID: 26606390. 12: Camacho-Muñoz D, Kasprzyk-Hordern B. Multi-residue enantiomeric analysis of human and veterinary pharmaceuticals and their metabolites in environmental samples by chiral liquid chromatography coupled with tandem mass spectrometry detection. Anal Bioanal Chem. 2015 Dec;407(30):9085-104. doi: 10.1007/s00216-015-9075-6. Epub 2015 Oct 13. PubMed PMID: 26462925. 13: Filist M, Szlaska I, Kaza M, Pawiński T. Validated HPLC-UV method for determination of naproxen in human plasma with proven selectivity against ibuprofen and paracetamol. Biomed Chromatogr. 2016 Jun;30(6):953-61. doi: 10.1002/bmc.3635. Epub 2015 Nov 11. PubMed PMID: 26458096. 14: Chen X, Vollertsen J, Nielsen JL, Dall AG, Bester K. Degradation of PPCPs in activated sludge from different WWTPs in Denmark. Ecotoxicology. 2015 Dec;24(10):2073-80. doi: 10.1007/s10646-015-1548-z. Epub 2015 Sep 25. PubMed PMID: 26407712. 15: Saunders LJ, Mazumder A, Lowe CJ. Pharmaceutical concentrations in screened municipal wastewaters in Victoria, British Columbia: A comparison with prescription rates and predicted concentrations. Environ Toxicol Chem. 2016 Apr;35(4):919-29. doi: 10.1002/etc.3241. Epub 2016 Jan 22. PubMed PMID: 26363402. 16: Chang CW, Chen YC, Liu CY. Separation and on-line preconcentration of nonsteroidal anti-inflammatory drugs by microemulsion electrokinetic chromatography. Electrophoresis. 2015 Nov;36(21-22):2745-2753. doi: 10.1002/elps.201500160. Epub 2015 Sep 25. PubMed PMID: 26257197. 17: Mavroudi MC, Kapnissi-Christodoulou CP. Combined use of l-alanine tert butyl ester lactate and trimethyl-β-cyclodextrin for the enantiomeric separations of 2-arylpropionic acids nonsteroidal anti-inflammatory drugs. Electrophoresis. 2015 Oct;36(19):2442-50. doi: 10.1002/elps.201500143. Epub 2015 Sep 7. PubMed PMID: 26080944. 18: Wang N, Wang F, Meng Y, Yang GH, Chen JW, Wang JX. Albumin Supplement Affects the Metabolism and Metabolism-Related Drug-Drug Interaction of Fenoprofen Enantiomers. Chirality. 2015 Jul;27(7):436-40. doi: 10.1002/chir.22462. Epub 2015 Jun 3. PubMed PMID: 26037509. 19: Roldán-Pijuán M, Pedersen-Bjergaard S, Gjelstad A. Parallel artificial liquid membrane extraction of acidic drugs from human plasma. Anal Bioanal Chem. 2015 Apr;407(10):2811-9. doi: 10.1007/s00216-015-8505-9. Epub 2015 Feb 15. PubMed PMID: 25682297. 20: Kyle ME, Wang JC, Shin JJ. Impact of nonaspirin nonsteroidal anti-inflammatory agents and acetaminophen on sensorineural hearing loss: a systematic review. Otolaryngol Head Neck Surg. 2015 Mar;152(3):393-409. doi: 10.1177/0194599814564533. Epub 2015 Jan 5. Review. PubMed PMID: 25560405; PubMed Central PMCID: PMC4465569.

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Ro 17-1812

Ro 17-1812