MedKoo Biosciences, Inc.
Tel:   +1-919-636-5577    Fax:   +1-919-980-4831    Email:   sales@medkoo.com
Search
Login Register
Search
MedKoo Cat#: 317537 | Name: Citalopram Hydrobromide
Featured

Description:

WARNING: This product is for research use only, not for human or veterinary use.

Citalopram Hydrobromide is an antidepressant drug of the selective serotonin reuptake inhibitor (SSRI) class. It has U.S. Food and Drug Administration approval to treat major depression and is prescribed off-label for other conditions. As a selective serotonin reuptake inhibitor, citalopram hydrobromide selectively inhibits the CNS neuronal reuptake of serotonin, thereby potentiating serotonergic activity in the central nervous system.

Chemical Structure

Citalopram Hydrobromide
Citalopram Hydrobromide
CAS#59729-32-7 (HBr)

Theoretical Analysis

MedKoo Cat#: 317537

Name: Citalopram Hydrobromide

CAS#: 59729-32-7 (HBr)

Chemical Formula: C20H22BrFN2O

Exact Mass: 0.0000

Molecular Weight: 405.30

Elemental Analysis: C, 59.27; H, 5.47; Br, 19.71; F, 4.69; N, 6.91; O, 3.95

Price and Availability

Size Price Availability Quantity
1g USD 250.00 2 Weeks
5g USD 550.00 2 Weeks
Bulk Inquiry
Buy Now
Add to Cart
Related CAS #
207559-01-1 (oxalate) 59729-33-8 (free base) 59729-32-7 (HBr)
Synonym
Citalopram Hydrobromide; Celexa; Cipramil; Citalopram HBr; HSDB 7042; EINECS 261-890-6; Lu 10-171-B; CPD000326936;
IUPAC/Chemical Name
1-[3-(dimethylamino)propyl]-1-(4-fluorophenyl)-3H-2-benzofuran-5-carbonitrile, hydrobromide
InChi Key
WIHMBLDNRMIGDW-UHFFFAOYSA-N
InChi Code
InChI=1S/C20H21FN2O.BrH/c1-23(2)11-3-10-20(17-5-7-18(21)8-6-17)19-9-4-15(13-22)12-16(19)14-24-20;/h4-9,12H,3,10-11,14H2,1-2H3;1H
SMILES Code
CN(C)CCCC1(C2=C(CO1)C=C(C=C2)C#N)C3=CC=C(C=C3)F.Br
Appearance
White to off-white solid powder.
Purity
>98% (or refer to the Certificate of Analysis)
Shipping Condition
Shipped under ambient temperature as non-hazardous chemical. This product is stable enough for a few weeks during ordinary shipping and time spent in Customs.
Storage Condition
Dry, dark and at 0 - 4 C for short term (days to weeks) or -20 C for long term (months to years).
Solubility
Soluble in DMSO, not in water
Shelf Life
>2 years if stored properly
Drug Formulation
This drug may be formulated in DMSO
Stock Solution Storage
0 - 4 C for short term (days to weeks), or -20 C for long term (months).
HS Tariff Code
2934.99.9001
More Info

Preparing Stock Solutions

The following data is based on the product molecular weight 405.30 Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which will affect the solvent volumes required to prepare stock solutions.

Recalculate based on batch purity %
Concentration / Solvent Volume / Mass 1 mg 5 mg 10 mg
1 mM 1.15 mL 5.76 mL 11.51 mL
5 mM 0.23 mL 1.15 mL 2.3 mL
10 mM 0.12 mL 0.58 mL 1.15 mL
50 mM 0.02 mL 0.12 mL 0.23 mL
1: Raza A, Ansari TM. Spectrophotometric determination of citalopram hydrobromide in tablet dosage form using chloranil. Pak J Pharm Sci. 2014 Mar;27(2):255-60. PubMed PMID: 24577911. 2: Azmi SN, Al-Fazari A, Al-Badaei M, Al-Mahrazi R. Utility of eosin Y as a complexing reagent for the determination of citalopram hydrobromide in commercial dosage forms by fluorescence spectrophotometry. Luminescence. 2015 Mar 31. doi: 10.1002/bio.2905. [Epub ahead of print] PubMed PMID: 25829234. 3: Abdouss M, Azodi-Deilami S, Asadi E, Shariatinia Z. Synthesis of molecularly imprinted polymer as a sorbent for solid phase extraction of citalopram from human serum and urine. J Mater Sci Mater Med. 2012 Jun;23(6):1543-52. doi: 10.1007/s10856-012-4623-5. Epub 2012 Apr 7. PubMed PMID: 22484836. 4: King BH, Dukes K, Donnelly CL, Sikich L, McCracken JT, Scahill L, Hollander E, Bregman JD, Anagnostou E, Robinson F, Sullivan L, Hirtz D. Baseline factors predicting placebo response to treatment in children and adolescents with autism spectrum disorders: a multisite randomized clinical trial. JAMA Pediatr. 2013 Nov;167(11):1045-52. doi: 10.1001/jamapediatrics.2013.2698. PubMed PMID: 24061784. 5: Blumenthal SR, Castro VM, Clements CC, Rosenfield HR, Murphy SN, Fava M, Weilburg JB, Erb JL, Churchill SE, Kohane IS, Smoller JW, Perlis RH. An electronic health records study of long-term weight gain following antidepressant use. JAMA Psychiatry. 2014 Aug;71(8):889-96. doi: 10.1001/jamapsychiatry.2014.414. PubMed PMID: 24898363. 6: Khajavi D, Farokhnia M, Modabbernia A, Ashrafi M, Abbasi SH, Tabrizi M, Akhondzadeh S. Oral scopolamine augmentation in moderate to severe major depressive disorder: a randomized, double-blind, placebo-controlled study. J Clin Psychiatry. 2012 Nov;73(11):1428-33. doi: 10.4088/JCP.12m07706. Epub 2012 Oct 16. PubMed PMID: 23146150. 7: Stevenson E, Schembri F, Green DM, Burns JD. Serotonin syndrome associated with clozapine withdrawal. JAMA Neurol. 2013 Aug;70(8):1054-5. doi: 10.1001/jamaneurol.2013.95. PubMed PMID: 23753931. 8: Dixit S, Park JH. Penicillin G as a novel chiral selector in capillary electrophoresis. J Chromatogr A. 2014 Jan 24;1326:134-8. doi: 10.1016/j.chroma.2013.12.018. Epub 2013 Dec 15. PubMed PMID: 24373536. 9: Khatri N, Simpson KL, Lin RC, Paul IA. Lasting neurobehavioral abnormalities in rats after neonatal activation of serotonin 1A and 1B receptors: possible mechanisms for serotonin dysfunction in autistic spectrum disorders. Psychopharmacology (Berl). 2014 Mar;231(6):1191-200. doi: 10.1007/s00213-013-3242-2. Epub 2013 Aug 24. PubMed PMID: 23975037; PubMed Central PMCID: PMC3933458. 10: Raza A. Development and application of spectrophotometric methods for the determination of citalopram hydrobromide in dosage forms. Chem Pharm Bull (Tokyo). 2006 Apr;54(4):432-4. PubMed PMID: 16595940. 11: Dadfar MR, Baghinia MR. Salvage use of citalopram for treatment of fluoxetine-resistant premature ejaculation in recently married men: a prospective clinical trial. Urol J. 2010 Winter;7(1):40-4. PubMed PMID: 20209455. 12: Peremans K, Audenaert K, Hoybergs Y, Otte A, Goethals I, Gielen I, Blankaert P, Vervaet M, van Heeringen C, Dierckx R. The effect of citalopram hydrobromide on 5-HT2A receptors in the impulsive-aggressive dog, as measured with 123I-5-I-R91150 SPECT. Eur J Nucl Med Mol Imaging. 2005 Jun;32(6):708-16. PubMed PMID: 15739093. 13: King BH, Hollander E, Sikich L, McCracken JT, Scahill L, Bregman JD, Donnelly CL, Anagnostou E, Dukes K, Sullivan L, Hirtz D, Wagner A, Ritz L; STAART Psychopharmacology Network. Lack of efficacy of citalopram in children with autism spectrum disorders and high levels of repetitive behavior: citalopram ineffective in children with autism. Arch Gen Psychiatry. 2009 Jun;66(6):583-90. doi: 10.1001/archgenpsychiatry.2009.30. PubMed PMID: 19487623; PubMed Central PMCID: PMC4112556. 14: Raman B, Sharma BA, Ghugare PD, Karmuse PP, Kumar A. Semi-preparative isolation and structural elucidation of an impurity in citalopram by LC/MS/MS. J Pharm Biomed Anal. 2009 Oct 15;50(3):377-83. doi: 10.1016/j.jpba.2009.05.017. Epub 2009 May 27. PubMed PMID: 19556091. 15: Lydiatt WM, Denman D, McNeilly DP, Puumula SE, Burke WJ. A randomized, placebo-controlled trial of citalopram for the prevention of major depression during treatment for head and neck cancer. Arch Otolaryngol Head Neck Surg. 2008 May;134(5):528-35. doi: 10.1001/archotol.134.5.528. PubMed PMID: 18490576. 16: Egashira N, Matsumoto Y, Mishima K, Iwasaki K, Fujioka M, Matsushita M, Shoyama Y, Nishimura R, Fujiwara M. Low dose citalopram reverses memory impairment and electroconvulsive shock-induced immobilization. Pharmacol Biochem Behav. 2006 Jan;83(1):161-7. Epub 2006 Feb 21. PubMed PMID: 16492387. 17: Grandoso L, Torrecilla M, Pineda J, Ugedo L. alpha(2)-Adrenoceptor involvement in the in vitro inhibitory effect of citalopram on a subpopulation of rat locus coeruleus neurons. Eur J Pharmacol. 2005 Jul 4;517(1-2):51-8. PubMed PMID: 15975573. 18: Tohgi H, Abe T, Nakanishi M, Takahashi S, Furuichi H, Matsumura T, Kurimoto T, Izumi J, Ikeda Y. Effects of citalopram, a synthetic serotonin uptake inhibitor, on indoleamine and catecholamine concentrations in the cerebrospinal fluid of freely moving rats. J Neural Transm Park Dis Dement Sect. 1995;9(2-3):111-9. PubMed PMID: 8526996. 19: Rao RN, Raju AN, Narsimha R. Isolation and characterization of degradation products of citalopram and process-related impurities using RP-HPLC. J Sep Sci. 2008 Jun;31(10):1729-38. doi: 10.1002/jssc.200700410. PubMed PMID: 18481321. 20: Kelly CA, Upex A, Spencer EP, Flanagan RJ, Bateman DN. Adult respiratory distress syndrome and renal failure associated with citalopram overdose. Hum Exp Toxicol. 2003 Feb;22(2):103-5. PubMed PMID: 12693836.