Synonym
Cinolazepam; Gerodorm; Cinolazepamum; OX-373; OX373; OX 373;
IUPAC/Chemical Name
3-[7-chloro-5-(2-fluorophenyl)-3-hydroxy-2-oxo-3H-1,4-benzodiazepin-1-yl]propanenitrile
InChi Key
XAXMYHMKTCNRRZ-UHFFFAOYSA-N
InChi Code
InChI=1S/C18H13ClFN3O2/c19-11-6-7-15-13(10-11)16(12-4-1-2-5-14(12)20)22-17(24)18(25)23(15)9-3-8-21/h1-2,4-7,10,17,24H,3,9H2
SMILES Code
C1=CC=C(C(=C1)C2=NC(C(=O)N(C3=C2C=C(C=C3)Cl)CCC#N)O)F
Purity
>98% (or refer to the Certificate of Analysis)
Shipping Condition
Shipped under ambient temperature as non-hazardous chemical. This product is stable enough for a few weeks during ordinary shipping and time spent in Customs.
Storage Condition
Dry, dark and at 0 - 4 C for short term (days to weeks) or -20 C for long term (months to years).
Solubility
Soluble in DMSO, not in water
Shelf Life
>2 years if stored properly
Drug Formulation
This drug may be formulated in DMSO
Stock Solution Storage
0 - 4 C for short term (days to weeks), or -20 C for long term (months).
HS Tariff Code
2934.99.9001
Preparing Stock Solutions
The following data is based on the
product
molecular weight
357.77
Batch specific molecular weights may vary
from batch to batch
due to the degree of hydration, which will
affect the solvent
volumes required to prepare stock solutions.
| Concentration / Solvent Volume / Mass |
1 mg |
5 mg |
10 mg |
| 1 mM |
1.15 mL |
5.76 mL |
11.51 mL |
| 5 mM |
0.23 mL |
1.15 mL |
2.3 mL |
| 10 mM |
0.12 mL |
0.58 mL |
1.15 mL |
| 50 mM |
0.02 mL |
0.12 mL |
0.23 mL |
1: Saletu B, Kindshofer G, Anderer P, Grünberger J. Short-term sleep laboratory
studies with cinolazepam in situational insomnia induced by traffic noise. Int J
Clin Pharmacol Res. 1987;7(5):407-18. PubMed PMID: 2889679.
2: Oelschläger H, Volke J, Belal F. Analysis of drugs by polarography, XXXV: The
polarographic behaviour of
cinolazepam[1-(2-cyanoethyl)-7-chloro-3-hydroxy-5-(2-fluorophe n
yl)-1,3-dihydro-2H-1,4-benzodiazepin-2-one] and assay of its tablets. Arch Pharm
(Weinheim). 1992 Feb;325(2):65-8. PubMed PMID: 1605717.
3: Richards BL, Whittle SL, Buchbinder R. Muscle relaxants for pain management in
rheumatoid arthritis. Cochrane Database Syst Rev. 2012 Jan 18;1:CD008922. doi:
10.1002/14651858.CD008922.pub2. Review. PubMed PMID: 22258993.
4: Walash MI, Belal F, Metwally ME, Hefnawy MM. A selective fluorimetric method
for the determination of some 1,4-benzodiazepine drugs containing a hydroxyl
group at C-3. J Pharm Biomed Anal. 1994 Nov;12(11):1417-23. PubMed PMID: 7849137.
5: Mascher H, Nitsche V, Schütz H. Separation, isolation and identification of
optical isomers of 1,4-benzodiazepine glucuronides from biological fluids by
reversed-phase high-performance liquid chromatography. J Chromatogr. 1984 Mar
9;306:231-9. PubMed PMID: 6715462.
