SLL-039 | CAS#unknown | κ‑Opioid Receptor Agonist

MedKoo Cat#: 465337 | Name: SLL-039

Description:

WARNING: This product is for research use only, not for human or veterinary use.

SLL-039 is a κ‑Opioid Receptor Agonist with an Improved Central Nervous System Safety Profile.

Chemical Structure

SLL-039

CAS#unknown

Theoretical Analysis

MedKoo Cat#: 465337

Name: SLL-039

CAS#: unknown

Chemical Formula: C37H40N2O4

Exact Mass: 576.2988

Molecular Weight: 576.74

Elemental Analysis: C, 77.06; H, 6.99; N, 4.86; O, 11.10

Price and Availability

This product is currently not in stock but may be available through custom synthesis. To ensure cost efficiency, the minimum order quantity is 1 gram. The estimated lead time is 2 to 4 months, with pricing dependent on the complexity of the synthesis (typically high for intricate chemistries). Quotes for quantities below 1 gram will not be provided. To request a quote, please click the button below. Note: If this product becomes available in stock in the future, pricing will be listed accordingly.

Bulk Inquiry

Related CAS #

No Data

Synonym

SLL-039; SLL039; SLL 039;

IUPAC/Chemical Name

N-(4-((4aS,6R,7R,7aR,12bS)-3-(cyclopropylmethyl)-7,9-dimethoxy-1,2,3,4,5,6,7,7a-octahydro-4a,7-ethano-4,12-methanobenzofuro[3,2-e]isoquinolin-6-yl)phenyl)benzamide

InChi Key

OQJMOWFXPLEYKT-IPILQQOHSA-N

InChi Code

InChI=1S/C37H40N2O4/c1-41-29-15-12-26-20-30-35-16-17-37(42-2,34-36(35,31(26)32(29)43-34)18-19-39(30)22-23-8-9-23)28(21-35)24-10-13-27(14-11-24)38-33(40)25-6-4-3-5-7-25/h3-7,10-15,23,28,30,34H,8-9,16-22H2,1-2H3,(H,38,40)/t28-,30?,34-,35-,36+,37?/m1/s1

SMILES Code

O=C(C1=CC=CC=C1)NC(C=C2)=CC=C2[C@@H](C3)[C@@]4(OC)[C@H]5[C@]([C@@]3(CC4)C6C7)(CCN6CC8CC8)C9=C7C=CC(OC)=C9O5

Appearance

Solid powder

Purity

>98% (or refer to the Certificate of Analysis)

Shipping Condition

Shipped under ambient temperature as non-hazardous chemical. This product is stable enough for a few weeks during ordinary shipping and time spent in Customs.

Storage Condition

Dry, dark and at 0 - 4 C for short term (days to weeks) or -20 C for long term (months to years).

Solubility

To be determined

Shelf Life

>2 years if stored properly

Drug Formulation

To be determined

Stock Solution Storage

0 - 4 C for short term (days to weeks), or -20 C for long term (months).

HS Tariff Code

2934.99.9001

More Info

Instruction

View handling instruction

Preparing Stock Solutions

The following data is based on the product molecular weight 576.74 Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which will affect the solvent volumes required to prepare stock solutions.

Concentration / Solvent Volume / Mass	1 mg	5 mg	10 mg
1 mM	1.15 mL	5.76 mL	11.51 mL
5 mM	0.23 mL	1.15 mL	2.3 mL
10 mM	0.12 mL	0.58 mL	1.15 mL
50 mM	0.02 mL	0.12 mL	0.23 mL

1: He Q, Wei Y, Liu X, Ye R, Kong L, Li Z, Jiang S, Yu L, Chai J, Xie Q, Fu W, Wang Y, Li W, Qiu Z, Liu J, Shao L. Discovery of an M-Substituted N-Cyclopropylmethyl-7α-phenyl-6,14-endoethanotetrahydronorthebaine as a Selective, Potent, and Orally Active κ-Opioid Receptor Agonist with an Improved Central Nervous System Safety Profile. J Med Chem. 2021 Aug 13. doi: 10.1021/acs.jmedchem.1c01082. Epub ahead of print. PMID: 34387468. 2: Liu X, Jiang S, Kong L, Ye R, Xiao L, Xu X, He Q, Wei Y, Li Z, Sun H, Xie Q, Xu X, Lu Y, Wang Y, Li W, Fu W, Qiu Z, Liu J, Shao L. Exploration of the SAR Connection between Morphinan- and Arylacetamide-Based κ Opioid Receptor (κOR) Agonists Using the Strategy of Bridging. ACS Chem Neurosci. 2021 Mar 17;12(6):1018-1030. doi: 10.1021/acschemneuro.1c00034. Epub 2021 Mar 2. PMID: 33650843. 3: Xiao L, Wang Y, Zhang M, Wu W, Kong L, Ma Y, Xu X, Liu X, He Q, Qian Y, Sun H, Wu H, Lin C, Huang H, Ye R, Jiang S, Ye RF, Yuan C, Fang S, Xue D, Yang X, Chen H, Zheng Y, Yu L, Xie Q, Zheng L, Fu W, Li W, Qiu Z, Liu J, Shao L. Discovery of a Highly Selective and Potent κ Opioid Receptor Agonist from N-Cyclopropylmethyl-7α-phenyl-6,14-endoethanotetrahydronorthebaines with Reduced Central Nervous System (CNS) Side Effects Navigated by the Message- Address Concept. J Med Chem. 2019 Dec 26;62(24):11054-11070. doi: 10.1021/acs.jmedchem.9b00857. Epub 2019 Dec 6. PMID: 31738550.