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MedKoo Cat#: 565477 | Name: Cinromide

Description:

WARNING: This product is for research use only, not for human or veterinary use.

Cinromide is a novel modulator of slc6a19, robustly, selectively, and reproducibly inhibiting slc6a19

Chemical Structure

Cinromide
Cinromide
CAS#58473-74-8

Theoretical Analysis

MedKoo Cat#: 565477

Name: Cinromide

CAS#: 58473-74-8

Chemical Formula: C11H12BrNO

Exact Mass: 253.0102

Molecular Weight: 254.13

Elemental Analysis: C, 51.99; H, 4.76; Br, 31.44; N, 5.51; O, 6.30

Price and Availability

This product is currently not in stock but may be available through custom synthesis. To ensure cost efficiency, the minimum order quantity is 1 gram. The estimated lead time is 2 to 4 months, with pricing dependent on the complexity of the synthesis (typically high for intricate chemistries). Quotes for quantities below 1 gram will not be provided. To request a quote, please click the button below. Note: If this product becomes available in stock in the future, pricing will be listed accordingly.
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Related CAS #
No Data
Synonym
Cinromide; Vumide
IUPAC/Chemical Name
(E)-3-(3-Bromophenyl)-N-ethylprop-2-enamide
InChi Key
LDCXGZCEMNMWIL-VOTSOKGWSA-N
InChi Code
InChI=1S/C11H12BrNO/c1-2-13-11(14)7-6-9-4-3-5-10(12)8-9/h3-8H,2H2,1H3,(H,13,14)/b7-6+
SMILES Code
O=C(NCC)/C=C/C1=CC=CC(Br)=C1
Appearance
Solid powder
Purity
>98% (or refer to the Certificate of Analysis)
Shipping Condition
Shipped under ambient temperature as non-hazardous chemical. This product is stable enough for a few weeks during ordinary shipping and time spent in Customs.
Storage Condition
Dry, dark and at 0 - 4 C for short term (days to weeks) or -20 C for long term (months to years).
Solubility
Soluble in DMSO
Shelf Life
>3 years if stored properly
Drug Formulation
This drug may be formulated in DMSO
Stock Solution Storage
0 - 4 C for short term (days to weeks), or -20 C for long term (months).
HS Tariff Code
2934.99.9001
More Info

Preparing Stock Solutions

The following data is based on the product molecular weight 254.13 Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which will affect the solvent volumes required to prepare stock solutions.

Recalculate based on batch purity %
Concentration / Solvent Volume / Mass 1 mg 5 mg 10 mg
1 mM 1.15 mL 5.76 mL 11.51 mL
5 mM 0.23 mL 1.15 mL 2.3 mL
10 mM 0.12 mL 0.58 mL 1.15 mL
50 mM 0.02 mL 0.12 mL 0.23 mL
1: Danthi SJ, Liang B, Smicker O, Coupland B, Gregory J, Gefteas E, Tietz D, Klodnitsky H, Randall K, Belanger A, Kuntzweiler TA. Identification and Characterization of Inhibitors of a Neutral Amino Acid Transporter, SLC6A19, Using Two Functional Cell-Based Assays. SLAS Discov. 2019 Feb;24(2):111-120. doi: 10.1177/2472555218794627. Epub 2018 Dec 27. PubMed PMID: 30589598. 2: Pisani F, Oteri G, Di Perri R. [Lennox-Gestaut syndrome: therapeutic aspects]. Riv Neurol. 1989 Nov-Dec;59(6):217-9. Review. Italian. PubMed PMID: 2700841. 3: Double-blind, placebo-controlled evaluation of cinromide in patients with the Lennox-Gastaut Syndrome. The Group for the Evaluation of Cinromide in the Lennox-Gastaut Syndrome. Epilepsia. 1989 Jul-Aug;30(4):422-9. PubMed PMID: 2666120. 4: Bernásková K, Mares P, Rokyta R. Influence of cinromide on metrazol--induced seizures during ontogenesis in rats. Physiol Bohemoslov. 1988;37(2):123-30. PubMed PMID: 2975002. 5: Lane EA, Levy RH. Fractions metabolized in a triangular metabolic system: cinromide and two metabolites in the rhesus monkey. J Pharmacokinet Biopharm. 1985 Aug;13(4):373-86. PubMed PMID: 4087169. 6: Lin H, Levy RH, Lane EA, Gordon WP. Variability in the determination of fraction metabolized in a triangular metabolic problem and its resolution with stable isotope methodology. J Pharm Sci. 1984 Feb;73(2):285-7. PubMed PMID: 6707907. 7: Lane EA, Levy RH. In vivo evaluation of the Michaelis-Menten constant for a medium extraction ratio drug: application to cinromide in the rhesus monkey. J Pharm Sci. 1983 Nov;72(11):1352-4. PubMed PMID: 6644604. 8: Corwin HM, Dreifuss FE. Cinromide in the treatment of absence seizures. Epilepsia. 1983 Aug;24(4):427-30. PubMed PMID: 6409600. 9: Spilker B, Bruni J, Jones M, Upton A, Cato A, Cloutier G. A double-blind crossover study of cinromide versus placebo in epileptic outpatients with partial seizures. Epilepsia. 1983 Aug;24(4):410-21. PubMed PMID: 6409599. 10: Wilensky AJ, Ojemann LM, Friel PN, Almes MJ, Levy RH, Dodrill CB. Cinromide in epilepsy: a pilot study. Epilepsia. 1983 Aug;24(4):401-9. PubMed PMID: 6409598. 11: Allen JW, Hamilton MJ, Oxley J, Richens A. A controlled trial of cinromide. Epilepsia. 1983 Aug;24(4):422-6. PubMed PMID: 6347676. 12: Fromm GH, Terrence CF, Chattha AS. Effect of cinromide on inhibitory and excitatory mechanisms. Epilepsia. 1983 Aug;24(4):394-400. PubMed PMID: 6307676. 13: Lane EA, Levy RH. Pharmacokinetic relationships between cinromide and its metabolites in the rhesus monkey I: 3-Bromocinnamamide, an active metabolite. J Pharm Sci. 1983 May;72(5):493-6. PubMed PMID: 6864493. 14: Chiu P, Lipnowski S, Bruni J, Burnham WM. The effect of cinromide on "kindled" seizures in the rat. Neuropharmacology. 1982 Mar;21(3):273-6. PubMed PMID: 7070603. 15: Soroko FE, Grivsky E, Maxwell RA. Cinromide (3-bromo-N-ethylcinnanamide), novel anticonvulsant agent. J Pharm Pharmacol. 1981 Nov;33(11):741-3. PubMed PMID: 6118420. 16: Wilensky AJ, Lane EA, Levy RH, Ojemann LM, Friel PN. Differential kinetics of cinromide and two of its metabolites in epileptic patients. Eur J Clin Pharmacol. 1981;21(2):149-53. PubMed PMID: 7341282. 17: DeAngelis RL, Robinson MM, Brown AR, Johnson TE, Welch RM. Quantitation of the anticonvulsant cinromide (3-bromo-N-ethylcinnamamide) and its major plasma metabolites by thin-layer chromatography. J Chromatogr. 1980 Dec 12;221(2):353-60. PubMed PMID: 7217303. 18: Lane EA, Levy RH. Prediction of steady-state behavior of metabolite from dosing of parent drug. J Pharm Sci. 1980 May;69(5):610-2. PubMed PMID: 6770076. 19: Lockard JS, Levy RH, DuCharme LL, Congdon WC. Cinromide's metabolite in monkey model: gastric administration and seizure control. Epilepsia. 1980 Apr;21(2):177-82. PubMed PMID: 6766857. 20: Lockard JS, Levy RH, DuCharme LL, Congdon WC. Experimental anticonvulsant cinromide in monkey model: preliminary efficacy. Epilepsia. 1979 Aug;20(4):339-50. PubMed PMID: 113205.