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MedKoo Cat#: 318873 | Name: Tiludronate disodium
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Description:

WARNING: This product is for research use only, not for human or veterinary use.

Tiludronate is a bisphosphonate used for treatment of Paget's disease of bone (osteitis deformans) in human medicine. In veterinary medicine, tiludronic acid is used to treat navicular disease and bone spavin in horses. Its trade names are Tildren and Equidronate. It is approved for treatment of navicular disease and distal tarsal osteoarthritis in Europe, and was approved for treatment of navicular disease in the United States in 2014. Tiludronate is a non-nitrogenous bisphosphonate that inhibits osteoclasts, the primary cell responsible for the breakdown of bone required for bone remodeling.

Chemical Structure

Tiludronate disodium
CAS#149845-07-8 (sodium)

Theoretical Analysis

MedKoo Cat#: 318873

Name: Tiludronate disodium

CAS#: 149845-07-8 (sodium)

Chemical Formula: C7H7ClNa2O6P2S

Exact Mass: 0.0000

Molecular Weight: 362.56

Elemental Analysis: C, 23.19; H, 1.95; Cl, 9.78; Na, 12.68; O, 26.48; P, 17.09; S, 8.84

Price and Availability

Size Price Availability Quantity
50mg USD 450.00
100mg USD 750.00
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Related CAS #
114084-78-5 (free acid) 149845-07-8 (sodium) 138926-19-9 (sodium hydrate)
Synonym
Tiludronate disodium; Tiludronic acid. trade name Skelid; Tildren and Equidronate.
IUPAC/Chemical Name
[(4-chlorophenyl)sulfanyl-[hydroxy(oxido)phosphoryl]methyl]-hydroxyphosphinate disodium
InChi Key
SKUHWSDHMJMHIW-UHFFFAOYSA-L
InChi Code
InChI=1S/C7H9ClO6P2S.2Na/c8-5-1-3-6(4-2-5)17-7(15(9,10)11)16(12,13)14;;/h1-4,7H,(H2,9,10,11)(H2,12,13,14);;/q;2*+1/p-2
SMILES Code
O=P(O)(C(SC1=CC=C(Cl)C=C1)P([O-])(O)=O)[O-].[Na+].[Na+]
Appearance
Solid powder
Purity
>98% (or refer to the Certificate of Analysis)
Shipping Condition
Shipped under ambient temperature as non-hazardous chemical. This product is stable enough for a few weeks during ordinary shipping and time spent in Customs.
Storage Condition
Dry, dark and at 0 - 4 C for short term (days to weeks) or -20 C for long term (months to years).
Solubility
Soluble in DMSO, not in water
Shelf Life
>2 years if stored properly
Drug Formulation
This drug may be formulated in DMSO
Stock Solution Storage
0 - 4 C for short term (days to weeks), or -20 C for long term (months).
HS Tariff Code
2934.99.9001
More Info
Related CAS# CAS#149845-07-8 (Tiludronate disodium salt) CAS#89987-06-4 (Tiludronate free acid)

Preparing Stock Solutions

The following data is based on the product molecular weight 362.56 Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which will affect the solvent volumes required to prepare stock solutions.

Recalculate based on batch purity %
Concentration / Solvent Volume / Mass 1 mg 5 mg 10 mg
1 mM 1.15 mL 5.76 mL 11.51 mL
5 mM 0.23 mL 1.15 mL 2.3 mL
10 mM 0.12 mL 0.58 mL 1.15 mL
50 mM 0.02 mL 0.12 mL 0.23 mL
1: Bertuglia A, Basano I, Pagliara E, Bottegaro NB, Spinella G, Bullone M. Effect of intravenous tiludronate disodium administration on the radiographic progression of osteoarthritis of the fetlock joint in Standardbred racehorses. J Am Vet Med Assoc. 2021 Sep 15;259(6):651-661. doi: 10.2460/javma.259.6.651. PMID: 34448617. 2: Gourlay J. Licence variations regarding tiludronate disodium. Vet Rec. 2015 Oct 24;177(16):423-4. doi: 10.1136/vr.h5621. PMID: 26494897. 3: Knych HK, Janes J, Kennedy L, McKemie DS, Arthur RM, Samol MA, Uzal FA, Scollay M. Detection and residence time of bisphosphonates in bone of horses. J Vet Diagn Invest. 2022 Jan;34(1):23-27. doi: 10.1177/10406387211050049. PMID: 34918585; PMCID: PMC8689024. 4: Rovel T, Coudry V, Denoix JM, Audigie F. Synostosis of the first and second ribs in six horses. J Am Vet Med Assoc. 2018 Sep 1;253(5):611-616. doi: 10.2460/javma.253.5.611. PMID: 30110211. 5: Podolska M, Białecka W, Kwiatkowska-Puchniarz B. Complexometric determination of diphosphonic acid derivatives. Part II. Acta Pol Pharm. 2000 May- Jun;57(3):159-65. PMID: 11143702. 6: Podolska M, Białecka W, Kwiatkowska-Puchniarz B, Tuszyńska E. Analysis of selected diphosphonic acid derivatives used in treatment of osteoporosis. Part I. Complexometric determination of diphosphonic acid derivatives. Acta Pol Pharm. 1997 Jul-Aug;54(4):267-72. PMID: 9511454.