Tigilanol tiglate, also known as EBC-46, is a diterpene ester derived from Fontainea picrosperma, has demonstrated potent in vitro cytotoxicity against various cancer cell lines, primarily through protein kinase C (PKC) activation. Studies indicate that tigilanol tiglate induces rapid tumor cell membrane disruption, leading to oncolysis, and stimulates an inflammatory response that promotes immune-mediated tumor clearance. In vitro assays have shown significant activity against melanoma, squamous cell carcinoma, and head and neck cancer models, with IC₅₀ values typically in the nanomolar range. Additionally, it triggers apoptotic and necrotic pathways, disrupts mitochondrial function, and enhances vascular disruption in tumor-associated endothelial cells.
MedKoo Cat#: 561134
Name: Tigilanol tiglate
CAS#: 943001-56-7
Chemical Formula: C30H42O10
Exact Mass: 562.2778
Molecular Weight: 562.66
Elemental Analysis: C, 64.04; H, 7.52; O, 28.43
The following data is based on the product molecular weight 562.66 Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which will affect the solvent volumes required to prepare stock solutions.
| Concentration / Solvent Volume / Mass | 1 mg | 5 mg | 10 mg |
|---|---|---|---|
| 1 mM | 1.15 mL | 5.76 mL | 11.51 mL |
| 5 mM | 0.23 mL | 1.15 mL | 2.3 mL |
| 10 mM | 0.12 mL | 0.58 mL | 1.15 mL |
| 50 mM | 0.02 mL | 0.12 mL | 0.23 mL |
